DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and ALA2

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_568633.2	Gene:	ALA2 / 834447	AraportID:	AT5G44240	Length:	1139	Species:	Arabidopsis thaliana

Alignment Length:	1058	Identity:	336/1058 - (31%)
Similarity:	544/1058 - (51%)	Gaps:	97/1058 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNET-ISPLVSLLPLLFVMIITALKE 91
            ||::..|||.:.|||.|.:|||.|.:..|||:|..:..:...| ::|..:..||:|:..::|.||
plant    52 NRISNRKYTLWNFLPKNLWEQFSRFMNQYFLLIACLQLWSLITPVNPASTWGPLIFIFAVSASKE 116

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRKC 156
            ..:||.|..|||..|...|.:::.|.::.|.:|.|..|::|.:|.:.:||||||||.:|.....|
plant   117 AWDDYHRYLSDKKANEKEVWIVKQGIKKHIQAQDIQVGNIVWLRENDEVPCDLVLLGTSDPQGVC 181

  Fly   157 FVNTANLDGETNLKTICVPTNYL---LAGDHELQGKDCIVCEPSSADLYTFNGRLELRS---GND 215
            :|.||.|||||:|||..:|:..:   |...|:::|  .|.|.....|:..|:..:.|..   .|
plant   182 YVETAALDGETDLKTRVIPSACVGIDLELLHKMKG--VIECPVPDKDIRRFDANMRLFPPFIDN- 243

  Fly   216 GAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFM 280
                   |...|||.|.||:...:::||...|.::|||..|||.::......|..:.:..|::..
plant   244 -------DVCSLTIKNTLLQSCYLRNTEWACGVSVYTGNQTKLGMSRGIAEPKLTAMDAMIDKLT 301

  Fly   281 VALIVGMIVVVVVLYL-------IERHKEAKIVPTMPYQGPPTNFNSAW-QIFEDFLSFLLLFNY 337
            .|:.|..||||:||.:       .|..|:..:  ..|.:.|       | ::....|.|.||.:.
plant   302 GAIFVFQIVVVLVLGIAGNVWKDTEARKQWYV--QYPEEAP-------WYELLVIPLRFELLCSI 357

  Fly   338 MVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNL 402
            |:|||..:::::.:.....|:..|:.:.|:||........:.::|:||||..:.:|||||||.|.
plant   358 MIPISIKVSLDLVKGLYAKFIEWDVEMIDQETGTASYAANTAISEDLGQVEYILTDKTGTLTDNK 422

  Fly   403 MKFVNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDA------DAAVLFEALAVCHTV-EVLQEVG 460
            |.|..|.:.|..|.       :|..|...:.:.|:|      |.......:|:|:|| .|..:.|
plant   423 MIFRRCCIGGIFYG-------NENGDALKDAQLLNAITSGSTDVIRFLTVMAICNTVLPVQSKAG 480

  Fly   461 DKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKV 525
            |                   ||  |:|.|.||.||:...:.|.:|:.|:..::|.| |: :...:
plant   481 D-------------------IV--YKAQSQDEDALVIAASKLHMVFVGKNANLLEI-RF-NGSVI 522

  Fly   526 QFKRLHVLEFSSERQRMSVIVRD-QSDTIWLYSKGAESAIFPRCKASPLVEQTDAQITKYAQNGL 589
            :::.|.:|||:|:|:||||:|:| |:..|.|.||||:.||.|..:|..........:..|:|.||
plant   523 RYEVLEILEFTSDRKRMSVVVKDCQNGKIILLSKGADEAILPYARAGQQTRTIGDAVEHYSQLGL 587

  Fly   590 RTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGE 654
            ||:.:..|.|.::|...:...:::|::.|.:|...||...:.:|::|.:||.||:||.||:.|.|
plant   588 RTLCLAWRELEENEYLEWSVKFKEASSLLVDREWRIAEVCQRLEHDLYILGVTAIEDRLQDGVPE 652

  Fly   655 TLEALQAAGLKIWVLTGDKVETAYNIGLACRHI---PRGSKQHFIINTTEPAELLARLD------ 710
            |:|.|:.||:..|:|||||..||..|.|:|..|   |:|  |..:|:.....::...|:
plant   653 TIETLRKAGINFWMLTGDKQNTAIQIALSCNFISPEPKG--QLLMIDGKTEEDVSRSLERVLLTM 715

  Fly   711 MIGDDEPE--VLIVDGTTITALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYIT 773
            .|...||:  ..::||..:...|:|..:.|.:||:..|..:|||::|.||:::|.::| ...|.|
plant   716 RITASEPKDVAFVIDGWALEIALKHHRKDFVELAILSRTAICCRVTPSQKAQLVEILK-SCDYRT 779

  Fly   774 AAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLF 838
            .|||||.|||.|||:|.||:||:||||.||||.||:||.||..|:||.||||.|:..|.|||..:
plant   780 LAIGDGGNDVRMIQQADIGVGISGREGLQAARAADYSIGRFRFLKRLILVHGRYSYNRTAFLSQY 844

  Fly   839 YCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPEL 903
            ..||:::|......:......|.|:::||:.|..:::.|.|.. .::::.|||.||.:::.||::
plant   845 SFYKSLLICFIQIFFSFISGVSGTSLFNSVSLMAYNVFYTSVP-VLVSVIDKDLSEASVMQHPQI 908

  Fly   904 YKPLAHNRQASMGVFSLWILNGFVQCFIIFFFT-YAMLNDANVLFNGGQTASFQTFGTMLITIIV 967
            .......|..:...|:.|.........|:|..| :|...:.:.:...|..|   ..|.:.:...|
plant   909 LFYCQAGRLLNPSTFAGWFGRSLFHAIIVFVITIHAYAYEKSEMEELGMVA---LSGCIWLQAFV 970

  Fly   968 IVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYTSGELYDVYNQFLSSLPIWLFTIICS 1032
            :........|..:::      |..::..|....:|::...|..:|.:..:..|....|:...:..
plant   971 VAQETNSFTVLQHLS------IWGNLVGFYAINFLFSAIPSSGMYTIMFRLCSQPSYWITMFLIV 1029

  Fly  1033 VACLLPDFVIKVVNDMYR 1050
            .|.:.|.|.:|.....||
plant  1030 GAGMGPIFALKYFRYTYR 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	17/37 (46%)
		ATPase-Plipid	28..1051	CDD:273734	336/1058 (32%)
		E1-E2_ATPase	84..>189	CDD:278548	42/107 (39%)
		Cation_ATPase	<489..568	CDD:289987	33/79 (42%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	60/246 (24%)
ALA2	NP_568633.2	PhoLip_ATPase_N	37..100	CDD:292826	19/47 (40%)
		ATPase-Plipid	50..1056	CDD:273734	336/1058 (32%)
		E1-E2_ATPase	105..>193	CDD:278548	37/87 (43%)
		Cation_ATPase	469..565	CDD:289987	42/118 (36%)
		HAD_like	<762..799	CDD:304363	20/37 (54%)
		PhoLip_ATPase_C	810..1049	CDD:292829	62/248 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820