DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9981 and ATP8B4

DIOPT Version :9

Sequence 1:NP_001259610.1 Gene:CG9981 / 32609 FlyBaseID:FBgn0030746 Length:1060 Species:Drosophila melanogaster
Sequence 2:XP_011520348.1 Gene:ATP8B4 / 79895 HGNCID:13536 Length:1257 Species:Homo sapiens


Alignment Length:1180 Identity:373/1180 - (31%)
Similarity:574/1180 - (48%) Gaps:219/1180 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN-ETISPLVSLLPLLFVMIITALKE 91
            ||:.|:||...||||:|.:|||:|....|||.:.|:..... .:::...:::||:.|:.:||:|:
Human    68 NRIHTSKYNILTFLPINLFEQFQRVANAYFLCLLILQLIPEISSLTWFTTIVPLVLVITMTAVKD 132

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNGK---EEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSAD 153
            ..:||.|.|||..||..:..|:.|.|   |:.:|   :..||::.:.|:..|..||:||.||...
Human   133 ATDDYFRHKSDNQVNNRQSEVLINSKLQNEKWMN---VKVGDIIKLENNQFVAADLLLLSSSEPH 194

  Fly   154 RKCFVNTANLDG----------------------------ETNLK---TICVPTNYLLAGDHELQ 187
            ..|:|.||.|||                            |||||   .:.| |:.|.|....|.
Human   195 GLCYVETAELDGSLCCYKDVPWVECQLFGAQEALPTFLKQETNLKVRHALSV-TSELGADISRLA 258

  Fly   188 GKD-CIVCEPSSADLYTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIY 251
            |.| .:|||..:..|..|.|.|   |..|...|       |..:.::|||..:::|....|..|:
Human   259 GFDGIVVCEVPNNKLDKFMGIL---SWKDSKHS-------LNNEKIILRGCILRNTSWCFGMVIF 313

  Fly   252 TGMHTKLQLNSRYTGNKSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPT 316
            .|..|||..||..|..|..|.::.:|. :|..|.|.::.:.::..|.                  
Human   314 AGPDTKLMQNSGKTKFKRTSIDRLMNT-LVLWIFGFLICLGIILAIG------------------ 359

  Fly   317 NFNSAWQ--------------------IFEDFL---SFLLLFNYMVPISAYMNIEVYRIFGMHFM 358
              ||.|:                    :|..||   |::::.|.:||||.|:::||.|:...:|:
Human   360 --NSIWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFI 422

  Fly   359 HNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLV 423
            :.|..:|......|.....:.|||||||:..:|||||||||:|:|.|..|.:.|..|     ..|
Human   423 NWDRKMYYSRKAIPAVARTTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIY-----GEV 482

  Fly   424 SEGTDEKFEL--EKLDADAAVLFEA----------------------------LAVCHTVEVLQE 458
            .:..|:|.|:  ||...|.:|..:|                            ||:||||     
Human   483 HDDLDQKTEITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDPKVHEFLRLLALCHTV----- 542

  Fly   459 VGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAE 523
                 :....|..|..          ||..||||.||:....:.|.:::.:..:.::|....:. 
Human   543 -----MSEENSAGELI----------YQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTL- 591

  Fly   524 KVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKAS--PLVEQTDAQITKYAQ 586
             |.::.|..|:|::.|:|||||||:....|.||||||::.:|.:...|  .|:..|...::::|.
Human   592 -VTYQLLAFLDFNNTRKRMSVIVRNPEGQIKLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFAG 655

  Fly   587 NGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEH 651
            .||||:|:..|.|.|.....:.::...||.....|:|.||..||.:|.:|.||||||:||.|||.
Human   656 EGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGATAVEDKLQEG 720

  Fly   652 VGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFII---NTTEPAELLAR----- 708
            |.||:.:|..|.:|||||||||.|||.|||.||..:.......|:|   |..|..|.|.:     
Human   721 VIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQNL 785

  Fly   709 ---------------------LDMI------GDDEPEVLIVDGTTITALLE-HTPRQFADLALRC 745
                                 ||.|      ||   ..||::|.::...|| .......:||..|
Human   786 FGQNRNFSNGHVVCEKKQQLELDSIVEETITGD---YALIINGHSLAHALESDVKNDLLELACMC 847

  Fly   746 RAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFS 810
            :.|:|||::||||:::|.|:|:.:..:|.||||||||||||:.||||:||:|:||.||...:|:|
Human   848 KTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQEGLQAVLASDYS 912

  Fly   811 IARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDI 875
            .|:|..|:||.||||.::..|:...:.::.|||...|.....:..:..:||..||:..::.||:|
Human   913 FAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNI 977

  Fly   876 VYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTY-AM 939
            ||.|.....:.|.|:|.|::..:..|:||||...|...:...|.:.:|:|.....::||..| |.
Human   978 VYTSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFIPYGAF 1042

  Fly   940 LNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYN 1004
            .|.|..  :|...|.:|:|...:.|.:|||.::::.|...|.|:.|...|..|||.:.  :.|:.
Human  1043 YNVAGE--DGQHIADYQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIAIYF--SILFT 1103

  Fly  1005 LYTSGELYDVY-NQF---------LSSLPIWLFTIICSVACLLPDFVIKVVN-DMY--------- 1049
            ::::| ::.:: |||         |:...|||..::.:||.::|....:.:. |:|         
Human  1104 MHSNG-IFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPTLSDQIRR 1167

  Fly  1050 -RKVPLKSKP 1058
             :|...|::|
Human  1168 WQKAQKKARP 1177

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9981NP_001259610.1 PhoLip_ATPase_N 20..66 CDD:292826 18/37 (49%)
ATPase-Plipid 28..1051 CDD:273734 370/1171 (32%)
E1-E2_ATPase 84..>189 CDD:278548 43/138 (31%)
Cation_ATPase <489..568 CDD:289987 28/78 (36%)
HAD_like <758..807 CDD:304363 28/48 (58%)
PhoLip_ATPase_C 804..1050 CDD:292829 75/267 (28%)
ATP8B4XP_011520348.1 PhoLip_ATPase_N 51..116 CDD:292826 18/47 (38%)
ATPase-Plipid 65..1167 CDD:273734 370/1168 (32%)
Cation_ATPase 538..634 CDD:289987 36/117 (31%)
HAD_like <875..906 CDD:304363 23/30 (77%)
PhoLip_ATPase_C 906..1160 CDD:292829 75/258 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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