DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp8b5p

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_038966915.1	Gene:	Atp8b5p / 691125	RGDID:	1587460	Length:	1191	Species:	Rattus norvegicus

Alignment Length:	1126	Identity:	356/1126 - (31%)
Similarity:	554/1126 - (49%)	Gaps:	175/1126 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISPL---VSLLPLLFVMIIT 87
            |.|.:.|:||::|.|||:|.:|||:|....||||:..:...  ..||.|   .:::||:.|:.||
  Rat    53 PDNSIKTSKYSFFNFLPVNLFEQFQRLANAYFLILLFLQLI--PQISSLAWYTTVIPLIVVLSIT 115

  Fly    88 ALKEGLED------------YSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDV 140
            .:|:.::|            ..|.:||:.||...|.::.||:.|....:.:..||::.:.||..|
  Rat   116 GVKDAIDDVVKWLPGLPSLHLKRHQSDQQVNNRSVLILVNGRIEENKWRNVQVGDIIKLENDHPV 180

  Fly   141 PCDLVLLQSSSADRKCFVNTANLDGETNLKTICVPTNYLLAGDHE--------LQGKDCIVCEPS 197
            ..|::||.||......::.||:||||||||   |........|.|        ..|:  :.|||.
  Rat   181 TADVLLLSSSEPYGLTYIETADLDGETNLK---VKQAVSATSDMEDNLELLSAFNGE--VRCEPP 240

  Fly   198 SADLYTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNS 262
            :..|..|:|.|          |..||...|..:.|||||..:::|:...|..:|||..|||..||
  Rat   241 NNKLDRFSGTL----------SYLGDTYFLDYERLLLRGCIIRNTDWCYGLVVYTGPDTKLMQNS 295

  Fly   263 RYTGNKSASSEKYINRFMVALIV-------GMIVVVVVLYLI-ERHKEAKIVPTMPYQGPPTNFN 319
                .:|.....:|:..|..|::       ||..::.:.:.| |.::.......:|::...|  :
  Rat   296 ----GRSTFKRTHIDHLMNVLVLWIFMLLGGMCFLLSIGHGIWESNRGYHFQAFLPWERYIT--S 354

  Fly   320 SAWQIFEDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEEL 384
            ||......|.|:.::.|.|||||.|:::|:.|:...::::.|..::....:.|.:...:.|||||
  Rat   355 SAASSALAFWSYFIVLNTMVPISLYVSVEIIRLGNSYYINWDRKMFYAPKNTPAQARTTTLNEEL 419

  Fly   385 GQVNILFSDKTGTLTKNLMKFVNCYVPGTNY-------------------QLQNTHLVSEGTDEK 430
            |||..:|||||||||:|:|.|..|.:.|..|                   .....||    .|.|
  Rat   420 GQVEYVFSDKTGTLTENVMIFNKCSINGKTYGYSYDENGQCVPKSPSNKVDFSYNHL----ADPK 480

  Fly   431 FEL-EKLDADAA--------VLFEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQ 486
            |.. :|...:|.        :.|..|::||||           .|.|.|  :..|:       ||
  Rat   481 FSFYDKTLVEAVKSEDPLVYLFFLCLSLCHTV-----------MSEEKV--EGELV-------YQ 525

  Fly   487 ASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSD 551
            |.||||.||:....:.|.|:..:..:.:::.......  .::.|.:|:||:||:||||||:...|
  Rat   526 AQSPDEGALVTASRNFGFVFHSRTPETITVIEMGRVR--VYRLLAILDFSNERKRMSVIVQTPED 588

  Fly   552 TIWLYSKGAESAIF----PRCKASPLVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYR 612
            .:.|:.|||::.|:    |.|.|  |.:.|..|:..:|..||||:.|..|.|  |:.| |:...:
  Rat   589 RVMLFCKGADTIIYELLHPSCAA--LSDVTMDQLDDFASEGLRTLMVAYREL--DKAF-FQTWIK 648

  Fly   613 K---ANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKV 674
            |   |...|.||.:.:|..||.:|.:|.||||||:||.||..|.||:..|..|.:|||||||||.
  Rat   649 KHGEAWLTLENREKKLALVYEEIERDLVLLGATAIEDKLQSGVPETIVTLNKAKIKIWVLTGDKQ 713

  Fly   675 ETAYNIGLACRHIPRGSKQHFIINTTEPAELLARL---------DMIGDDEP------------- 717
            |||.||..:||.........|::..|:...:|..|         :.:.:.:|
  Rat   714 ETAVNIAYSCRIFKDEMDAVFMVEGTDRETVLEELRTARKKMKPESLLESDPINIYLARKSKMPF 778

  Fly   718 ----EV------LIVDGTTITALLE-HTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKY 771
                ||      |::.|.::...|| :|..:....|..|:.|:|||::||||:::|.|:||.||.
  Rat   779 KAVDEVPNGSYGLVISGCSLAYALESNTEFELLRTACMCKGVVCCRMTPLQKAQVVDLVKRYKKV 843

  Fly   772 ITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLV 836
            :|.||||||||:.||:.||||:||:|:||.||...:|||..:|..|:||.||||.::..|:...:
  Rat   844 VTLAIGDGANDIGMIKAAHIGVGISGQEGMQATLSSDFSFCQFRYLQRLLLVHGRWSYNRMCKFL 908

  Fly   837 LFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHP 901
            .::.|||...|.....|..::.:||..||:..::..::::|.|.....|::.:||.:|...|.:|
  Rat   909 SYFFYKNFAFTLVHFWYAFFNGFSAQTVYDIWFITFYNLIYTSLPILGLSLFEKDVNETWSLCYP 973

  Fly   902 ELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFN-----GGQTASFQTFGTM 961
            |||:|..||...:...|...:|:|....|::||.      ....:||     |...:.||:|..:
  Rat   974 ELYEPGQHNLYFNKKEFIKCLLHGIYSSFVLFFV------PMGTVFNSERSDGKDISDFQSFSLL 1032

  Fly   962 LITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYTSG---------ELYDVYNQ 1017
            :.|.::.|..:::.|...|.|..|.|....|:..:....:|  |.:.|         ....|...
  Rat  1033 VQTTLIWVMTMQIALSTTYWTMINHAFTWGSLGLYFCILFL--LCSDGLCLMFPSVFNFLGVARN 1095

  Fly  1018 FLSSLPIWLFTIICSVACLLP 1038
            .|:...:||..::.||.||:|
  Rat  1096 GLNQPQMWLCLVLSSVLCLIP 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/39 (46%)
		ATPase-Plipid	28..1051	CDD:273734	355/1124 (32%)
		E1-E2_ATPase	84..>189	CDD:278548	36/124 (29%)
		Cation_ATPase	<489..568	CDD:289987	27/82 (33%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	67/249 (27%)
Atp8b5p	XP_038966915.1	P-type_ATPase_APLT_Dnf-like	54..1008	CDD:319770	329/1013 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820