Protein Alignment CG9981 and ATP8B2

DIOPT Version :9

• Sequence 1: NP_001259610.1
• Gene: CG9981 / 32609
• FlyBaseID: FBgn0030746
• Length: 1060
• Species: Drosophila melanogaster
• Sequence 2: NP_001354863.1
• Gene: ATP8B2 / 57198
• HGNCID: 13534
• Length: 1209
• Species: Homo sapiens
• Alignment Length: 1118
• Identity: 363/1118 - (32%)
• Similarity: 580/1118 - (51%)
• Gaps: 143/1118 - (12%)

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN-ETISPLVSLLPLLFVMIITALKE 91
            |.:.|:||...||||:|.:|||:.....|||.:.|:..... .::|...:::||:.|:.|||:|:
Human    51 NCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKD 115

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNG---KEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSAD 153
            ..:||.|.|||..||..:..|:.||   :|:.:|   :..||::.:.|:..|..||:||.||...
Human   116 ATDDYFRHKSDNQVNNRQSQVLINGILQQEQWMN---VCVGDIIKLENNQFVAADLLLLSSSEPH 177

  Fly   154 RKCFVNTANLDGETNLKT-ICVPTNYLLAGDHELQGKDC-IVCEPSSADLYTFNGRLELRSGNDG 216
            ..|::.||.||||||:|. ..:|....|....:|...|. ::|||.:..|..|:|.|..:.
Human   178 GLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKE---- 238

  Fly   217 AGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMV 281
                  :..||:..|:||||..:::||...|..|:.|..|||..||..|..|..|.::.:|. :|
Human   239 ------NKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNT-LV 296

  Fly   282 ALIVGMIVVVVVLYLI-----ERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSF---LLLFNYM 338
            ..|.|.:|.:.|:..|     |.....:....:|:.   ...:||:  |..||||   :::.|.:
Human   297 LWIFGFLVCMGVILAIGNAIWEHEVGMRFQVYLPWD---EAVDSAF--FSGFLSFWSYIIILNTV 356

  Fly   339 VPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLM 403
            ||||.|:::||.|:...:|::.|..::..:...|.....:.||||||||..:|||||||||:|:|
Human   357 VPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIM 421

  Fly   404 KFVNCYVPGTNY-----QLQNTHLVSEG-----------TDEKF--------ELEKL-DADAAVL 443
            .|..|.:.|.:|     .|.:...:.|.           .|:||        |..|: |......
Human   422 VFNKCSINGHSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHTHEF 486

  Fly   444 FEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEG 508
            |..|::||||            .||..:|....        |:|.||||.||:....:.|.|:..
Human   487 FRLLSLCHTV------------MSEEKNEGELY--------YKAQSPDEGALVTAARNFGFVFRS 531

  Fly   509 QENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKAS-- 571
            :....:::....:|  :.::.|.:|:|::.|:|||||||:....|.||.|||::.:..|...|
Human   532 RTPKTITVHEMGTA--ITYQLLAILDFNNIRKRMSVIVRNPEGKIRLYCKGADTILLDRLHHSTQ 594

  Fly   572 PLVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLS--NRNELIASCYETVEN 634
            .|:..|...:.:||..||||:.:..:.|  ||.::.|...|:....|:  :|.:.:||.||.|||
Human   595 ELLNTTMDHLNEYAGEGLRTLVLAYKDL--DEEYYEEWAERRLQASLAQDSREDRLASIYEEVEN 657

  Fly   635 ELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFII-- 697
            .:.||||||:||.||:.|.||:..|..|.:|||||||||.|||.|||.:|:.:.....:.||:
Human   658 NMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTG 722

  Fly   698 -------------------------------NTTEPAELLARLDMIGDDEPEVLIVDGTTITALL 731
                                           :....::|.:.|:.:..:  ..|:::|.::...|
Human   723 HTVLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSSKLTSVLEAVAGE--YALVINGHSLAHAL 785

  Fly   732 E-HTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGI 795
            | ....:|.:.|..|:||:|||::||||:::|.|:|:.||.:|.||||||||||||:.||||:||
Human   786 EADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGVGI 850

  Fly   796 TGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYS 860
            :|:||.||...:|:|.::|:.|:||.||||.::..|:...:.::.|||...|.....:..:..:|
Human   851 SGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFS 915

  Fly   861 ATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNG 925
            |..||:..::.|::|||.|.....:.:.|:|..|:..:.:|:||:|...|...:...|.:.|..|
Human   916 AQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQG 980

  Fly   926 FVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMIL 990
            .....::||..|.:..|| ...:|.|.|.:|:|...:.|.:|||.::::.|...|.|..|...|.
Human   981 IYTSVLMFFIPYGVFADA-TRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFIW 1044

  Fly   991 ASIAAFMLTTYLYNLYTSGELYDVY-NQF---------LSSLPIWLFTIICSVACLLPDFVIKVV 1045
            .|:|.:.  ..|:.::::| |:|:: |||         |:...:||..::.:|.|::|     ||
Human  1045 GSLAVYF--AILFAMHSNG-LFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMP-----VV 1101

  Fly  1046 NDMYRKVPLKSKP 1058
              .:|.:.|..||
Human  1102 --AFRFLRLNLKP 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	16/37 (43%)
		ATPase-Plipid	28..1051	CDD:273734	359/1109 (32%)
		E1-E2_ATPase	84..>189	CDD:278548	40/108 (37%)
		Cation_ATPase	<489..568	CDD:289987	26/78 (33%)
		HAD_like	<758..807	CDD:304363	30/48 (63%)
		PhoLip_ATPase_C	804..1050	CDD:292829	71/255 (28%)
ATP8B2	NP_001354863.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1181..1209

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144912
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650