Protein Alignment CG9981 and ATP8B2

DIOPT Version :10

• Sequence 1: NP_573124.1
• Gene: CG9981 / 32609
• FlyBaseID: FBgn0030746
• Length: 1060
• Species: Drosophila melanogaster
• Sequence 2: XP_047281955.1
• Gene: ATP8B2 / 57198
• HGNCID: 13534
• Length: 1210
• Species: Homo sapiens
• Alignment Length: 1121
• Identity: 362/1121 - (32%)
• Similarity: 578/1121 - (51%)
• Gaps: 148/1121 - (13%)

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN-ETISPLVSLLPLLFVMIITALKE 91
            |.:.|:||...||||:|.:|||:.....|||.:.|:..... .::|...:::||:.|:.|||:|:
Human    51 NCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKD 115

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNG---KEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSAD 153
            ..:||.|.|||..||..:..|:.||   :|:.:|   :..||::.:.|:..|..||:||.||...
Human   116 ATDDYFRHKSDNQVNNRQSQVLINGILQQEQWMN---VCVGDIIKLENNQFVAADLLLLSSSEPH 177

  Fly   154 RKCFVNTANLDGETNLKT-ICVPTNYLLAGDHELQGKDC-IVCEPSSADLYTFNGRLELRSGNDG 216
            ..|::.||.||||||:|. ..:|....|....:|...|. ::|||.:..|..|:|.|..:.
Human   178 GLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKE---- 238

  Fly   217 AGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMV 281
                  :..||:..|:||||..:::||...|..|:.|..|||..||..|..|..|.::.:|. :|
Human   239 ------NKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNT-LV 296

  Fly   282 ALIVGMIVVVVVLYLI-----ERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSF---LLLFNYM 338
            ..|.|.:|.:.|:..|     |.....:....:|:.   ...:||:  |..||||   :::.|.:
Human   297 LWIFGFLVCMGVILAIGNAIWEHEVGMRFQVYLPWD---EAVDSAF--FSGFLSFWSYIIILNTV 356

  Fly   339 VPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLM 403
            ||||.|:::||.|:...:|::.|..::..:...|.....:.||||||||..:|||||||||:|:|
Human   357 VPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIM 421

  Fly   404 KFVNCYVPGTNY-----QLQNTHLVSEG-----------TDEKF--------ELEKL-DADAAVL 443
            .|..|.:.|.:|     .|.:...:.|.           .|:||        |..|: |......
Human   422 VFNKCSINGHSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHTHEF 486

  Fly   444 FEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEG 508
            |..|::||||            .||..:|....        |:|.||||.||:....:.|.|:..
Human   487 FRLLSLCHTV------------MSEEKNEGELY--------YKAQSPDEGALVTAARNFGFVFRS 531

  Fly   509 QENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKAS-- 571
            :....:::....:|  :.::.|.:|:|::.|:|||||||:....|.||.|||::.:..|...|
Human   532 RTPKTITVHEMGTA--ITYQLLAILDFNNIRKRMSVIVRNPEGKIRLYCKGADTILLDRLHHSTQ 594

  Fly   572 PLVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLS--NRNELIASCYETVEN 634
            .|:..|...:.:||..||||:.:..:.|  ||.::.|...|:....|:  :|.:.:||.||  |.
Human   595 ELLNTTMDHLNEYAGEGLRTLVLAYKDL--DEEYYEEWAERRLQASLAQDSREDRLASIYE--EE 655

  Fly   635 EL---DLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFI 696
            .|   .||||||:||.||:.|.||:..|..|.:|||||||||.|||.|||.:|:.:.....:.||
Human   656 SLWYFQLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFI 720

  Fly   697 I---------------------------------NTTEPAELLARLDMIGDDEPEVLIVDGTTIT 728
            :                                 :....::|.:.|:.:..:  ..|:::|.::.
Human   721 VTGHTVLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSSKLTSVLEAVAGE--YALVINGHSLA 783

  Fly   729 ALLE-HTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIG 792
            ..|| ....:|.:.|..|:||:|||::||||:::|.|:|:.||.:|.||||||||||||:.||||
Human   784 HALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIG 848

  Fly   793 IGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYD 857
            :||:|:||.||...:|:|.::|:.|:||.||||.::..|:...:.::.|||...|.....:..:.
Human   849 VGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFC 913

  Fly   858 LYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWI 922
            .:||..||:..::.|::|||.|.....:.:.|:|..|:..:.:|:||:|...|...:...|.:.|
Human   914 GFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICI 978

  Fly   923 LNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFA 987
            ..|.....::||..|.:..|| ...:|.|.|.:|:|...:.|.:|||.::::.|...|.|..|..
Human   979 AQGIYTSVLMFFIPYGVFADA-TRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHF 1042

  Fly   988 MILASIAAFMLTTYLYNLYTSGELYDVY-NQF---------LSSLPIWLFTIICSVACLLPDFVI 1042
            .|..|:|.:.  ..|:.::::| |:|:: |||         |:...:||..::.:|.|::|
Human  1043 FIWGSLAVYF--AILFAMHSNG-LFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMP---- 1100

  Fly  1043 KVVNDMYRKVPLKSKP 1058
             ||  .:|.:.|..||
Human  1101 -VV--AFRFLRLNLKP 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_573124.1	P-type_ATPase_APLT_Dnf-like	28..936	CDD:319770	324/987 (33%)
ATP8B2	XP_047281955.1	P-type_ATPase_APLT_Dnf-like	50..992	CDD:319770	324/987 (33%)