DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and atp10d

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_005156631.1	Gene:	atp10d / 571658	ZFINID:	ZDB-GENE-090313-231	Length:	1365	Species:	Danio rerio

Alignment Length:	1269	Identity:	376/1269 - (29%)
Similarity:	580/1269 - (45%)	Gaps:	311/1269 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFF-VNETISPLVSLLPLLFVMIITALKE 91
            |.:.|||||..:|:|:|.::||.||...|||.:.::::. ..|.....::::||..|:.:.|.|:
Zfish    74 NSIRTTKYTLISFIPMNLFQQFHRAANLYFLFLVLLNWVPAVEAFQKEITMIPLAVVLTVIAFKD 138

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNGKEE-IINSQF--IVPGDLVVVRNDGDVPCDLVLLQSSSAD 153
            .:|||.|.:.||.:|.. :|.:.:||:: .:..::  :..||||.:..:..:|.|:|||.||.::
Zfish   139 AMEDYRRYRYDKKINNT-LTHVYSGKQQRYVERRWAEVCVGDLVRLCCNEIIPADMVLLHSSDSN 202

  Fly   154 RKCFVNTANLDGETNLK------------TICVPTNYLLAGDHELQGKDCIVCEPSSADLYTFNG 206
            ..|.:.|||||||||||            ...||.|:          ...|.||..:.||..|.|
Zfish   203 GVCHIETANLDGETNLKQRQVVRDLTQQGAEFVPENF----------SSRIECENPNNDLRRFRG 257

  Fly   207 RLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSAS 271
            .:| ..|....|        |..:|||||...|::||.|:|..:|.|..||...|:.....|.:.
Zfish   258 FME-HPGKVRVG--------LHSENLLLRSCTVRNTETVIGIVVYAGHETKAMQNNSGPRYKRSK 313

  Fly   272 SEKYIN---RFMVALIVGMIVVVVV---LYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLS 330
            .|:.:|   .:.|||::.|..:..:   |:|.|......::        |.|.:.|...|..|.:
Zfish   314 LERRLNLDVLWSVALLLLMCFIAAIGHGLWLSELEDPIFMI--------PDNTHPALAAFYMFWT 370

  Fly   331 FLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKT 395
            .:::...::|||.|::||:.::..::|:.|||.||:...|...:..|.|:.|:|||:..||||||
Zfish   371 MIIVLQVLIPISLYVSIEIVKLGQIYFIQNDLDLYNPVLDTGVQCRALNITEDLGQIQYLFSDKT 435

  Fly   396 GTLTKNLMKFVNCYVPGTNY----------QLQ-------------------------------- 418
            ||||:|.|.|..|.|.||.|          |.:
Zfish   436 GTLTENRMLFRRCTVAGTEYPHHENAVSLEQYEDQACGDVDRSLTLRSRTSKKSLSCKSLSCNRS 500

  Fly   419 -----------NTHLVSEG------------------TDEKFELE----------KLDADAAVL- 443
                       :||.|.:.                  .|.:..::          .|..|||.:
Zfish   501 SVSLNTLTAESDTHSVHDTLCRHTTGAFSSTMECAVVPDPQLHMKLSTLSSPMRSPLRPDAAEIS 565

  Fly   444 -----FEALAVCHTVEV---------------------LQEV----------------------- 459
                 |.||.||:||.|                     |:|:
Zfish   566 LILDFFLALTVCNTVVVSSPSQPRHVVQMPVVRTPLRSLEEMKAMFQKLSLPRFPHSPNTNTDTP 630

  Fly   460 ----------------------------------------------------------------- 459

Zfish   631 PSLTKKLFARGRSASYFPNSNPQTPVTPLESPVKLSGTPSDTPPALITPALSSSGAWGEDAEDKK 695

  Fly   460 --GDKTLESSES--VSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYP 520
              .|...:.|||  ..|:..|:       |:|.||||.||::...:.|....|:..:.:.:. .|
Zfish   696 QAKDNAADESESDDEDEEEELL-------YEAESPDEAALVQAAKAYGCTLLGRSPEQVLVA-VP 752

  Fly   521 SAEKVQFKRLHVLEFSSERQRMSVIVRDQ-SDTIWLYSKGAESAIFPRCK------ASPLVEQTD 578
            ....:....||||.|.|.|:||||:||.. :..:.:|:|||::.|....|      :..::|.|.
Zfish   753 GTGPLSISLLHVLPFHSARKRMSVVVRHPLTGEVVVYTKGADNVIMELAKQAEDDFSREVMELTQ 817

  Fly   579 AQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATA 643
            ..:.:||:.||||:.|.:::|.:.|...:.:.:..|.|.:.||.||:....|.:|.:|.|||||.
Zfish   818 RHLDQYAREGLRTLCVAKKVLGEQEYEAWMKRHEYAETSIENREELLLESAERLETDLTLLGATG 882

  Fly   644 LEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLAR 708
            :.|.|||.|.||:||||.||:|:|||||||.|||.||..||: :.|.:....:.|........||
Zfish   883 IVDRLQEEVPETIEALQEAGIKVWVLTGDKQETAINIAFACK-LLRPTDHILMANCDSKEACEAR 946

  Fly   709 L--------DMIGDDEPE-------VLIVDGTTIT-ALLEHTPRQFADLALRCRAVLCCRLSPLQ 757
            |        .:...||||       ||::||.|:. ||.:.....|.||...||:|:|||.:|||
Zfish   947 LQELQLEVQQVTKADEPEGDCISDCVLVIDGRTLDYALQKELQGAFLDLTCCCRSVICCRSTPLQ 1011

  Fly   758 KSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFL 822
            ||::|.|::.:.:.:|.|||||||||||||.|.:|:||:|:||.||...:||:|:||:.||:|.|
Zfish  1012 KSQVVRLVRDKLEVMTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMSSDFAISRFKFLRKLIL 1076

  Fly   823 VHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAI 887
            ||||:...|||.::|::.|||::....:..||.:..:|.:.:.||..|..|::::.|....|..:
Zfish  1077 VHGHWCYARLANMILYFFYKNVMYVNLLFWYQFFCGFSGSTMTNSWVLIFFNLLFTSVPPLVYGV 1141

  Fly   888 CDKDYSEETLLSHPELYKPLAHNRQASM-GVFSLWILNGFVQ---CFIIFFFTYAMLNDANVLFN 948
            .|||.|.||||..|:|||. ..|.||.: ..|.|.||:.|.|   ||.|.:|.||. :|..|.
Zfish  1142 LDKDVSAETLLKLPDLYKS-GQNSQAYLPTTFWLNILDAFYQSLVCFFIPYFAYAG-SDIGVF-- 1202

  Fly   949 GGQTASFQT--FGTMLITIIVIVGNLKLLLVAHYMTYRNFAMIL-------ASIAAFMLTTYLYN 1004
                 ||.:  .|:.|:.|:     |..::.:..:|:.:.::::       |.:..|.:|....|
Zfish  1203 -----SFASPINGSALLIIL-----LHQVIESRTLTWIHASLLIFSGLFYYAFVLLFSITCVTCN 1257

  Fly  1005 LYTSGELYDVYNQFLSSLPIWLFTIICSVACLLP 1038
            ..|:.  |.:..:.:|....:|..::.:|..|||
Zfish  1258 SPTNP--YGIETKMMSEPLYYLVCVLTTVLALLP 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	16/37 (43%)
		ATPase-Plipid	28..1051	CDD:273734	376/1269 (30%)
		E1-E2_ATPase	84..>189	CDD:278548	38/119 (32%)
		Cation_ATPase	<489..568	CDD:289987	27/79 (34%)
		HAD_like	<758..807	CDD:304363	27/48 (56%)
		PhoLip_ATPase_C	804..1050	CDD:292829	77/248 (31%)
atp10d	XP_005156631.1	PhoLip_ATPase_N	69..122	CDD:292826	17/47 (36%)
		ATPase-Plipid	71..1309	CDD:273734	376/1269 (30%)
		E1-E2_ATPase	128..>215	CDD:278548	30/87 (34%)
		Cation_ATPase	<723..799	CDD:289987	26/76 (34%)
		HAD_like	<1027..1074	CDD:304363	30/46 (65%)
		PhoLip_ATPase_C	1058..1303	CDD:292829	77/248 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750