DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and atp8b3

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_003201102.2	Gene:	atp8b3 / 566530	ZFINID:	ZDB-GENE-050208-424	Length:	1174	Species:	Danio rerio

Alignment Length:	1089	Identity:	349/1089 - (32%)
Similarity:	540/1089 - (49%)	Gaps:	136/1089 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFF-VNETISPLVSLLPLLFVMIITALKE 91
            |.|.:.|||..||.|||.||||:||...:||:|.|:... |..||....::||||.|:.:...|:
Zfish    61 NVVRSYKYTPLTFFPLNLYEQFQRAANLFFLLIVILQCVPVIATIPWYTTMLPLLIVLFVRGCKD 125

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRKC 156
            ...|..|.:||..:|.....::.....:.:..:.:..||::.|..|..:|.||:||.|:.....|
Zfish   126 LATDVGRRRSDAQINRRPCDILTPEGFKTVKWKDVCVGDILRVHKDQVIPADLLLLCSTEPYSLC 190

  Fly   157 FVNTANLDGETNLK-----TICVPTNYLLAGD---HELQGKDCIV-CEPSSADLYTFNGRLELRS 212
            :|.||::|||||||     |:   |:..|.||   ..|...|.|| ||..:.:|::|.|....:
Zfish   191 YVETADIDGETNLKFRQALTV---THTELNGDSTEQNLAAFDAIVRCEEPNGNLHSFRGEFHWK- 251

  Fly   213 GNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYIN 277
                     |:...|..|:|||||..:::|:...|..||||..:|:..|......|....|..:|
Zfish   252 ---------GERHLLGTDHLLLRGTVLRNTDYAYGLTIYTGSDSKILQNCGRLKLKKTHVEILLN 307

  Fly   278 RFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNS-AWQIFEDFLSFLLLFNYMVPI 341
            :.::.:::.|:...::|.:.....|.:|.|...........:| |:|.|..|..:::|.:..:|:
Zfish   308 KTVLVILLFMLTTALLLAIGAGIFEYRISPNYDVVSIVQRDSSPAYQGFLTFWGYIILLSPSMPM 372

  Fly   342 SAYMNIEVYRIFGMHFMHN-----DLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKN 401
            |.|:..||     :|.:|.     |:.:|.|:|:.|.....:.||||||||..|.||||||||:|
Zfish   373 SLYITFEV-----IHMVHCLLIGWDVEMYWEDTNCPAHARTTTLNEELGQVGHLLSDKTGTLTQN 432

  Fly   402 LMKFVNCYVPGTNYQLQNTHLVSEGTDE----------------KFELEKL--------DADAAV 442
            .:.|..|::.|        |:..:.:.:                ||..::|        ..:...
Zfish   433 RLLFRQCFIAG--------HIYGDISQKSKPLDLSWNRFSCGGLKFSDQRLVDKLRGRGSLECQE 489

  Fly   443 LFEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYE 507
            .|.|||:||||                :||.     ::.:..|||:||||:||:.....||.|:.
Zfish   490 FFTALALCHTV----------------MSEW-----KDGLPHYQAASPDEEALVCAARELGWVFL 533

  Fly   508 GQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRC-KAS 571
            .:..|.|:|.........|.  |.:|:|:|:|:||||:||.....:.||||||:..|..|. |..
Zfish   534 SRTRDTLTISEMGLTRNYQL--LALLDFTSKRRRMSVLVRSPGGQLKLYSKGADIVILERLQKDW 596

  Fly   572 PLVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENEL 636
            ||.|.||..:..:||:.|||:.|..|.:.:.....:......|.|...|:..|:...|:.:|.:|
Zfish   597 PLQESTDRALELFAQSCLRTLCVAVRPVPEALWTEWSRALNLAGTATGNQETLLEEIYDQMEKDL 661

  Fly   637 DLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTE 701
            .|||.||:||.|||.|.||:.:|:.||:|:|||||||.|||.|:|.||:.:...:.   :|...|
Zfish   662 MLLGVTAIEDRLQEGVPETIASLRRAGVKVWVLTGDKTETAVNVGYACKLMDPDTT---LIQGEE 723

  Fly   702 PAELL----ARLDMIGDDEPEVLIVDGTTI---TALLEHTPR------------QFADLALRCRA 747
            ..:||    :.:| :...||||.|.|...:   .||:...|.            :|..|:.:|::
Zfish   724 LRQLLESPSSNVD-VKSKEPEVWITDKKAVMSKAALVISGPELAELTKSSEWGAKFVALSGQCQS 787

  Fly   748 VLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIA 812
            |||||::|.||:|:|.::::....||.|||||||||:||:.||||:|:.|.||.||...|||::|
Zfish   788 VLCCRVTPAQKAEVVEMVRKHSASITMAIGDGANDVNMIKTAHIGVGLCGVEGSQAVLNADFALA 852

  Fly   813 RFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVY 877
            :|..||:|.|||||::..|::.|:.::.||..........|..|:.:||..:|.|.|:.||...|
Zfish   853 QFSFLRKLLLVHGHWSYYRISILLRYFLYKTTAFALVHTWYSFYNGFSAQPMYESWYISLFTTTY 917

  Fly   878 ISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLND 942
            .|.......|.::|.|..:.|..||:|......:..:..|.:..:|..|....|.||....:|..
Zfish   918 TSLPIQCTGIFEQDISARSCLCWPEIYSIGQKKQLFNPSVLASTLLYSFYSSIIFFFVPMGILQY 982

  Fly   943 ANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTT---YLYN 1004
            :        ...|||....:.|.::....|:::|...|.|..|.|.::.|:|||.|:|   :...
Zfish   983 S--------ALDFQTLAITIETSVLFATTLEVILCTKYWTKWNVAAVIFSLAAFFLSTLALHSTR 1039

  Fly  1005 LYTS--------GELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVV 1045
            |:|:        |...:.|    |:..:||...:.:...:||....:.:
Zfish  1040 LFTASPKDYFFLGASQNAY----STPEVWLTIFVTTCVAVLPSITTRAL 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	20/37 (54%)
		ATPase-Plipid	28..1051	CDD:273734	349/1089 (32%)
		E1-E2_ATPase	84..>189	CDD:278548	33/112 (29%)
		Cation_ATPase	<489..568	CDD:289987	31/78 (40%)
		HAD_like	<758..807	CDD:304363	26/48 (54%)
		PhoLip_ATPase_C	804..1050	CDD:292829	67/253 (26%)
atp8b3	XP_003201102.2	PhoLip_ATPase_N	52..109	CDD:292826	23/47 (49%)
		ATPase-Plipid	58..1096	CDD:273734	349/1089 (32%)
		Cation_ATPase	<515..591	CDD:289987	31/77 (40%)
		R3H	650..706	CDD:294210	31/55 (56%)
		HAD_like	<813..837	CDD:304363	17/23 (74%)
		PhoLip_ATPase_C	844..1084	CDD:292829	67/251 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578136
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650