DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and atp8b5b

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_691903.2	Gene:	atp8b5b / 563450	ZFINID:	ZDB-GENE-120502-1	Length:	1189	Species:	Danio rerio

Alignment Length:	1137	Identity:	368/1137 - (32%)
Similarity:	584/1137 - (51%)	Gaps:	165/1137 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN-ETISPLVSLLPLLFVMIITALKE 91
            |.:.|:||..|||||||.:|||:|....||:.:.|:..... .::|...:::|||.|:.||..|:
Zfish    39 NAIKTSKYNVFTFLPLNLFEQFQRLANAYFVFLLILQLIPQISSLSWFTTVVPLLLVLSITLAKD 103

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNGK---EEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSAD 153
            ..:|.:|.|:||.||..:|.|:.:|:   |..:|.|.   ||:|.:.|:..|..||:||.||...
Zfish   104 LSDDITRHKNDKQVNNRKVEVLIDGELKTERWMNVQV---GDIVKLENNEFVTADLLLLSSSEPL 165

  Fly   154 RKCFVNTANLDGETNLKT---------ICVPTNYLLAGDHELQGKDCIVCEPSSADLYTFNGRLE 209
            ...::.||.||||||||.         :|.....|.|...|::      |||.:..|..|.|.|.
Zfish   166 NLIYIETAELDGETNLKVKQALTLTGELCNDIQRLAAFKGEVR------CEPPNNRLDKFTGTLV 224

  Fly   210 LRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEK 274
            :          .|:...|..:.:||||..:::||...|..::.|..|||..||..:..|..|.:.
Zfish   225 V----------GGETFALDNERILLRGCTLRNTEWCFGLVLFGGPDTKLMQNSGKSIFKRTSIDH 279

  Fly   275 YINRFMVALIVGMIVVVVVLYLI-----ERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLL 334
            .:| .:|..|.|.:..:..:..|     |..:....:..:|   .....|::...|..|.|::::
Zfish   280 LMN-VLVLFIFGFLAFMCTILSIGNAIWEYQEGNSFIVFLP---RADGANASLSAFLTFWSYVII 340

  Fly   335 FNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLT 399
            .|.:||||.|:::|:.|:...:|:..|..:|..::|.|.:...:.|||||||:..:|||||||||
Zfish   341 LNTVVPISLYVSVEILRLGNSYFIDWDRKMYHVKSDTPAQARTTTLNEELGQIKYIFSDKTGTLT 405

  Fly   400 KNLMKFVNCYVPGTNY---------QLQNTHLVSEGT-----------DEKF--------ELEKL 436
            :|:|.|..|.:.|.:|         :::    |:|.|           |.||        |..||
Zfish   406 QNIMTFNRCSINGKSYGEVVDFAGQRVE----VTEKTEKVDFSWNLLADPKFFFHDHKLVEAVKL 466

  Fly   437 DA-DAAVLFEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCA 500
            .: :....|..||:|||  |:.|  :||         |..|.       |||.||||.||:....
Zfish   467 GSPEVHAFFRLLALCHT--VMPE--EKT---------QGDLF-------YQAQSPDEGALVTAAR 511

  Fly   501 SLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIF 565
            :.|.|:..:..:.:|:..  ...:..::.|.||:|::.|:|||||||:....:.||.|||::.|:
Zfish   512 NFGFVFRARTPETISVVE--MGIETTYELLAVLDFNNVRKRMSVIVRNPEGKLMLYCKGADTIIY 574

  Fly   566 ----PRCKASPLVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIA 626
                |.|  |.::|.|...:.:||..||||:|:..:.|.:|:...:...:.:|:..|.:|.|.:.
Zfish   575 ERLHPSC--SKVMEVTTEHLNEYAGEGLRTLALAYKDLDEDKFAEWRRRHHEASIALEDREEKLD 637

  Fly   627 SCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGS 691
            :.||.:|.:|.|:||:|:||.||:.|.:|:|.|..|.:|||||||||.|||.|||.:|..:....
Zfish   638 AIYEEIEKDLILIGASAVEDKLQDGVPQTIEQLAKADIKIWVLTGDKQETAENIGYSCNMLREEM 702

  Fly   692 KQHFII--NTTEPA--ELL-ARLDMIGD--DEPEV-----------------------LIVDGTT 726
            .:.||:  ||.|..  ||: ||..|..:  |||.:                       |:::|.:
Zfish   703 TEIFIVAANTAEEVREELVNARKKMSPESGDEPPMEKSRFLGKKSQVVEDEKVDGEYGLVINGHS 767

  Fly   727 IT-ALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAH 790
            :. ||.:....:....|..|:.|:|||::||||:::|.|:|:.||.:|.||||||||||||:.||
Zfish   768 LAFALQKDMQVELLRTACMCQTVICCRVTPLQKAQVVELVKKHKKAVTLAIGDGANDVSMIKTAH 832

  Fly   791 IGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQV 855
            ||:||:|:||.||...:|||.|:|..|:||.||||.::..|:...:.::.|||...|.....|..
Zfish   833 IGVGISGQEGMQAVLSSDFSFAQFRYLQRLLLVHGRWSYLRMCTFLRYFFYKNFTFTFVHFWYAF 897

  Fly   856 YDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSL 920
            :..:||..||:..|:.|:::||.:.....:::.|:|.::.....:|:||.|...|:..|...|:.
Zfish   898 FCGFSAQTVYDEWYITLYNLVYTALPVLGISLFDQDVNDRWSFQYPQLYAPGQMNQYFSKMAFAK 962

  Fly   921 WILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRN 985
            .:|:......|:||..:|.:.| .|..:|...|.:|:|..:..|.::|..:::|.|..:|.|..|
Zfish   963 ILLHSCYSSLILFFVPWAAMWD-TVRDDGKDIADYQSFALLAQTCLLIAVSVQLGLDTYYWTAVN 1026

  Fly   986 FAMILASIAAFMLTTYLYNLYTSGELYDVYNQFLSSLP-------------IWLFTIICSVACLL 1037
            ...:..|::.:...|  :.:|::|    :|..|.||.|             :||...:.::.|:|
Zfish  1027 HFFLWGSLSVYFAVT--FTMYSNG----MYLIFTSSFPFIGTARNSLNQPNVWLTIFLTTILCVL 1085

  Fly  1038 PDFVIK---------VVNDMYR-KV-PLKSKP 1058
            | .|.|         .:||..| || ..|::|
Zfish  1086 P-VVAKRFLFIQFKPTINDKVRHKVKQAKAEP 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/37 (49%)
		ATPase-Plipid	28..1051	CDD:273734	364/1127 (32%)
		E1-E2_ATPase	84..>189	CDD:278548	41/116 (35%)
		Cation_ATPase	<489..568	CDD:289987	28/82 (34%)
		HAD_like	<758..807	CDD:304363	30/48 (63%)
		PhoLip_ATPase_C	804..1050	CDD:292829	71/267 (27%)
atp8b5b	XP_691903.2	PhoLip_ATPase_N	25..87	CDD:292826	19/47 (40%)
		ATPase-Plipid	36..1107	CDD:273734	363/1126 (32%)
		Cation_ATPase	480..584	CDD:289987	42/127 (33%)
		HAD_like	<815..846	CDD:304363	23/30 (77%)
		PhoLip_ATPase_C	846..1100	CDD:292829	69/261 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578140
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750