DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9981 and atp11a

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_005171058.2	Gene:	atp11a / 562925	ZFINID:	ZDB-GENE-090311-52	Length:	1212	Species:	Danio rerio

Alignment Length:	1109	Identity:	400/1109 - (36%)
Similarity:	598/1109 - (53%)	Gaps:	130/1109 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QQKPLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISPLVSLLPLLFVMIIT 87
            |:.|.||:.::|||::.|:|.|.:|||||...||||||.:|...::...||:.|.|||.||:.:|
Zfish    43 QRFPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPMTSGLPLFFVITVT 107

  Fly    88 ALKEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSA 152
            |:|:|.||:.|.|:|..||...|.::::||.....||.:..||:|.|:.:...||||:||.:|..
Zfish   108 AIKQGYEDWIRHKADNSVNQCPVHIVQHGKVVRKQSQKLRVGDIVQVKENETFPCDLILLSTSRE 172

  Fly   153 DRKCFVNTANLDGETNLKT-ICVPTNYLLAGDHELQGKDC-IVCEPSSADLYTFNGRLELRSGND 215
            |..|||.||:||||::.|| ..|......:...|:..... |.||....|||.|.||:.:....|
Zfish   173 DGTCFVTTASLDGESSHKTYYAVQDTKAFSTAEEVDTLHATIECEQPQPDLYKFVGRINIYLDRD 237

  Fly   216 GAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFM 280
                 ...|.||..:||||||..:|:||.:...||||||.||:.||.:....|.::.||.:|.::
Zfish   238 -----EPIARPLGSENLLLRGATLKNTEYIHAVAIYTGMETKMALNYQSKSQKRSAVEKSMNAYL 297

  Fly   281 VA----LIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAW---------------QIFE 326
            :.    ||...::..|:.|:              :|..| |.:..|               :.|.
Zfish   298 IVYLCILISKALINTVLKYV--------------WQADP-NRDEPWYNQRTESERQRHVLIRAFT 347

  Fly   327 DFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILF 391
            |||:|::||||::|:|.|:.:|:.:..|.:|:..|..::|||..:...||.|:||||||||..:|
Zfish   348 DFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFILWDDDMFDEEVGERPLVNTSDLNEELGQVEYVF 412

  Fly   392 SDKTGTLTKNLMKFVNCYVPGTNY---QLQNTHLV-----------SEGTDEKFELEKLDADAAV 442
            :|||||||:|.|:...|.|.|..|   .:.|..::           |.|.:.| |.|:|
Zfish   413 TDKTGTLTENNMELRECCVDGHVYVPHAICNGQILPGAAGMDMIDSSPGVEGK-EREEL------ 470

  Fly   443 LFEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYE 507
            .|.||.:||||:|.:|      |:.:.:....|  .......|.:|||||.||:||...||..|.
Zfish   471 FFRALCLCHTVQVKEE------ETVDGIKRGIH--QGKATSFYISSSPDEVALVEGMKRLGFTYL 527

  Fly   508 GQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKASP 572
            ..::..:.|..... |..:|:.|.||.|.|.|:|||||||..|...:|:.|||:|::|||. .|.
Zfish   528 RLKDSHMEILNRED-EMERFELLDVLNFDSVRRRMSVIVRSNSGEYYLFCKGADSSVFPRV-VSG 590

  Fly   573 LVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEE---LYRKANTQLSNRNELIASCYETVEN 634
            .|||..|::...|..||||:.|..:.|:.:|   :||   |...|...|..|::.:|..|:.:|.
Zfish   591 KVEQVRARVEHNAVEGLRTLCVAYKRLSQEE---YEETCRLLTSAKLALQERDKKLAEAYDVIEK 652

  Fly   635 ELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINT 699
            :..||||||:||.||:...:|:|:|..||:|:|||||||:|||.....|.:...|.::  .:..|
Zfish   653 DFILLGATAVEDRLQDKAADTIESLHKAGIKVWVLTGDKMETAAATCYASKLFHRNTQ--ILELT 715

  Fly   700 TEPAELLARLDMI-----------------------GDDEPEVLIVDGTTITALLEHTPRQ---- 737
            |:..|..:..|::                       ||.:...||:||.|::|:|:  |.|
Zfish   716 TKRTEEQSLHDVLFDLSRTVLRQHGSMTRDTFSGLSGDYQDYGLIIDGATLSAVLK--PTQDATS 778

  Fly   738 --------FADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKY-ITAAIGDGANDVSMIQEAHIGI 793
                    |.::...|.||||||::||||::||.|||..|:: ||.||||||||||||.|||:||
Zfish   779 NGGNYKEIFLEICRNCSAVLCCRMAPLQKAQIVKLIKASKEHPITLAIGDGANDVSMILEAHVGI 843

  Fly   794 GITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDL 858
            ||.|:||:||||.:|::|.:|:.|:::.||||||...|:|.||.::.|||:.......|||.:..
Zfish   844 GIMGKEGRQAARNSDYAITKFKHLKKMLLVHGHYYYIRIAELVQYFFYKNVCFIFPQFLYQFFCG 908

  Fly   859 YSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWIL 923
            :|...:|::.||.|::|.:.|....:.::.::..:.:.|...|.||:.:|.|...:...|..|..
Zfish   909 FSQQPLYDTAYLTLYNISFTSLPILLYSLMEQHINMDILKRDPSLYRDIAKNSLLTWPTFIYWTF 973

  Fly   924 NGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQ-------TFGTMLITIIVIVGNLKLLLVAHYM 981
            .|.....:.||..:.:.::.....||...|:..       ||||::.|::|....|||.|..||.
Zfish   974 LGVFDAVVFFFGAFFLFDNTTFTSNGQLMATNTQMMFGNWTFGTLVFTVLVFTVTLKLALDTHYW 1038

  Fly   982 TYRNFAMILASIAAFMLTTYLYN-----LYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFV 1041
            |:.|..:|..|:..:::.:.|:.     ......:|.|:.|.|||.|.||..|:..:..||||.:
Zfish  1039 TWINHFVIWGSLLFYVIFSLLWGGIIWPFLNYQRMYYVFMQMLSSGPAWLSIILLIIVSLLPDVL 1103

  Fly  1042 IKVV 1045
            .||:
Zfish  1104 KKVL 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	22/42 (52%)
		ATPase-Plipid	28..1051	CDD:273734	398/1104 (36%)
		E1-E2_ATPase	84..>189	CDD:278548	41/105 (39%)
		Cation_ATPase	<489..568	CDD:289987	35/78 (45%)
		HAD_like	<758..807	CDD:304363	35/49 (71%)
		PhoLip_ATPase_C	804..1050	CDD:292829	76/254 (30%)
atp11a	XP_005171058.2	P-type_ATPase_APLT_Dnf-like	47..977	CDD:319770	360/973 (37%)
atp11a	XP_005171058.2	PhoLip_ATPase_C	854..1114	CDD:318452	76/254 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578123
Domainoid	1	1.000	219	1.000	Domainoid score	I2576
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	748	1.000	Inparanoid score	I555
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	1	1.000	-	-		FOG0004283
OrthoInspector	1	1.000	-	-		otm26470
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770