DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp8b1

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001001488.2	Gene:	Atp8b1 / 54670	MGIID:	1859665	Length:	1251	Species:	Mus musculus

Alignment Length:	1135	Identity:	359/1135 - (31%)
Similarity:	571/1135 - (50%)	Gaps:	178/1135 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN-ETISPLVSLLPLLFVMIITALKE 91
            |.:.|.||..|||||:|.:|||:||..|||||:.|:..... .|::...:|:|||.|:.|||:|:
Mouse    95 NAIKTYKYNGFTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGITAIKD 159

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRKC 156
            .::|.:|.|.||.:|.....||::|:.:||..:.|..||::.::.:..:|.|::||.||..:..|
Mouse   160 LVDDVARHKMDKEINNRTCEVIKDGRFKIIKWKDIQVGDVIRLKKNDFIPADILLLSSSEPNSLC 224

  Fly   157 FVNTANLDGETNLKTICVPTNYLLA---GDHELQGKDCIVCEPSSADLYTFNGRLELRSGNDGAG 218
            :|.||.||||||||       :.:|   .|..||.:|         :|.||:|.:|....|:...
Mouse   225 YVETAELDGETNLK-------FKMALEITDQYLQIED---------NLATFDGFIECEEPNNRLD 273

  Fly   219 SSAG------DALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYIN 277
            ...|      .:.||..|.:||||..:::|:...|..|:.|..||:..||..|..|....:..:|
Mouse   274 KFTGTLFWKNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMN 338

  Fly   278 RFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMVPIS 342
            ..:..:.:.:|:|...|.:...:.||::.....|.....|...:::.|.:|..::::.|.|||||
Mouse   339 YMVYTIFIVLILVSAGLAIGHAYWEAQVGNYSWYLYDGENATPSYRGFLNFWGYIIVLNTMVPIS 403

  Fly   343 AYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVN 407
            .|:::||.|:...||::.||.:|..|.|.|.:...:.|||:|||::.:|||||||||:|:|.|..
Mouse   404 LYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKK 468

  Fly   408 CYVPGTNY-----QLQNTHLVSEGTD--------------EKFELEKL----DADAAVLFEALAV 449
            |.:.||.|     ..|::|...|..|              :.:.:|::    :.:....|..|::
Mouse   469 CCINGTIYGDHRDASQHSHSKIELVDFSWNTFADGKLAFYDHYLIEQIQSGKEPEVRQFFFLLSI 533

  Fly   450 CHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDR------YQASSPDEKALLEGCASLGLVYEG 508
            ||||                           :|||      |||:||||.||:....:.|..:..
Mouse   534 CHTV---------------------------MVDRIDGQINYQAASPDEGALVNAARNFGFAFLA 571

  Fly   509 QENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRC-KASP 572
            :..:.:::....|..  .:..|.:|:|:|:|:|||:|||....:|.||.|||::.|:.|. :.:|
Mouse   572 RTQNTITVSELGSER--TYNVLAILDFNSDRKRMSIIVRTPEGSIRLYCKGADTVIYERLHRMNP 634

  Fly   573 LVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELD 637
            ..::|...:..:|...|||:.:..:.:.:.|...:...:..|:...|||:|.:...||.:|.:|.
Mouse   635 TKQETQDALDIFASETLRTLCLCYKEIEEKEFTEWNNKFMAASVASSNRDEALDKVYEEIEKDLI 699

  Fly   638 LLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPR------GSKQHFI 696
            ||||||:||.||:.|.||:..|..|.:|||||||||.|||.|||.||..:..      |...:.:
Mouse   700 LLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAENIGFACELLTEDTTICYGEDINSL 764

  Fly   697 INTT-------------------EPAELLARLDMIGDDEPEVLIVDGTTITALL----------- 731
            ::|.                   ||        .....|...||:.|:.:..:|
Mouse   765 LHTRMENQRNRGGVSAKFAPPVYEP--------FFPPGENRALIITGSWLNEILLEKKTKRSKIL 821

  Fly   732 -------------------------EHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKY 771
                                     |...:.|.|||..|.||:|||::|.||:.:|.|:||.||.
Mouse   822 KLKFPRTEEERRMRSQSRRRLEEKKEQRQKNFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKA 886

  Fly   772 ITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLV 836
            ||.|||||||||:||:.||||:||:|:||.||...:|:|.|:|..|:||.||||.::..|:...:
Mouse   887 ITLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFL 951

  Fly   837 LFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHP 901
            .::.|||...|.....|..::.|||...|...::.|::::|.|....::.:.|:|.|::..|..|
Mouse   952 RYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYSSLPVLLMGLLDQDVSDKLSLRFP 1016

  Fly   902 ELY----KPLAHNRQASMGVFSLWILNGFVQCFIIFFFTY-AMLNDANVLFNGGQTASFQTFGTM 961
            .||    :.|..|.:.    |.:.:|:|.:...::||... |.|.  .|..:|...:.:|:|...
Mouse  1017 GLYVVGQRDLLFNYKR----FFVSLLHGVLTSMVLFFIPLGAYLQ--TVGQDGEAPSDYQSFAVT 1075

  Fly   962 LITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYTSG--ELYDVYNQFLSSLP- 1023
            :.:.:||..|.::.|...|.|:.|...|..|||.:.  ..:::.:::|  .|:....||..:..
Mouse  1076 VASALVITVNFQIGLDTSYWTFVNAFSIFGSIALYF--GIMFDFHSAGIHVLFPSAFQFTGTASN 1138

  Fly  1024 ------IWLFTIICSVA-CLLPDFVIKVVN 1046
                  ||| |||.:|| ||||...|:.::
Mouse  1139 ALRQPYIWL-TIILTVAVCLLPVVAIRFLS 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	21/37 (57%)
		ATPase-Plipid	28..1051	CDD:273734	359/1135 (32%)
		E1-E2_ATPase	84..>189	CDD:278548	40/107 (37%)
		Cation_ATPase	<489..568	CDD:289987	26/78 (33%)
		HAD_like	<758..807	CDD:304363	31/48 (65%)
		PhoLip_ATPase_C	804..1050	CDD:292829	72/258 (28%)
Atp8b1	NP_001001488.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PhoLip_ATPase_N	86..142	CDD:292826	22/46 (48%)
		ATPase-Plipid	92..1179	CDD:273734	359/1135 (32%)
		E1-E2_ATPase	171..>234	CDD:278548	22/62 (35%)
		Cation_ATPase	534..628	CDD:289987	36/122 (30%)
		HAD_like	<875..919	CDD:304363	29/43 (67%)
		PhoLip_ATPase_C	919..1173	CDD:292829	72/258 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835021
Domainoid	1	1.000	98	1.000	Domainoid score	I7147
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650