DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp9b

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_006526569.1	Gene:	Atp9b / 50771	MGIID:	1354757	Length:	1167	Species:	Mus musculus

Alignment Length:	1141	Identity:	335/1141 - (29%)
Similarity:	540/1141 - (47%)	Gaps:	172/1141 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KKKSADPLRIQIGGIESRQQK-PLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN 68
            :||......:.:|..|..::| |.|.:...||..|||:|...||||:..:..|||:::...|...
Mouse   108 RKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVVSCSQFVPA 172

  Fly    69 ETISPLVSL-LPLLFVMIITALKEGLEDYSRSKSDKLVNT---ARVTVIRNGKEEIINSQFIVPG 129
            ..|..|.:. .||.||:.:|..:|.::::.|.:.||.:|:   :::||  .||.::.:|...| |
Mouse   173 LKIGYLYTYWAPLGFVLAVTIAREAIDEFRRFQRDKEMNSQLYSKLTV--RGKVQVKSSDIQV-G 234

  Fly   130 DLVVVR---------------------NDGDVPCDLVLLQSSSADRKCFVNTANLDGETN--LKT 171
            ||::|.                     .:..:|.|:|.|::|.....||:.|..|||||:  ||.
Mouse   235 DLIIVEKAFLSCGQHPLMYMLQASASFQNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKV 299

  Fly   172 ICVPTNYLLAGDHELQGKDCIVCEPSSADLYTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRG 236
            ....|..|.|..........:..:....|:::|.|.......:.....|      |:|:|.|...
Mouse   300 AVSCTQRLPALGDLFSISAYVYAQKPQLDIHSFEGTFTREDSDPPIHES------LSIENTLWAS 358

  Fly   237 VRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMVALIVGMIVVVVVLYLIERHK 301
            ..|.| ..|:|..||||..|:..:|:....||....:..:|:...||.:.::|:.||:
Mouse   359 TIVAS-GTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELNQLTKALFLALVVLSVVM------- 415

  Fly   302 EAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMVPISAYMNIEVYR-IFGMHFMHNDLHLY 365
                |....:.||       |  :.:...|||||:|::|||..:|:::.: .:|...|
Mouse   416 ----VTLQGFAGP-------W--YRNLFRFLLLFSYIIPISLRVNLDMGKAAYGWMIM------- 460

  Fly   366 DEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEK 430
            .:|......|..|.:.||||::..|.:|||||||:|.|.|...:: ||         ||.|||..
Mouse   461 KDENIPGTVVRTSTIPEELGRLVYLLTDKTGTLTQNEMVFKRLHL-GT---------VSYGTDTM 515

  Fly   431 FELE----------------------------------KLDADAAV--LFEALAVCHTVEVLQE- 458
            .|::                                  |....:.:  ..:|:|:||.|..:.|
Mouse   516 DEIQSHVLNSYLQVHSQPSGHNPSSAPLRRSQSSTPKVKKSVSSRIHEAVKAIALCHNVTPVYEA 580

  Fly   459 ----VGD-KTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSI-C 517
                .|: :..|:.:..|:::.        .||||||||.||:....|:||....:  |:.|: .
Mouse   581 RAGITGETEFAEADQDFSDENR--------TYQASSPDEVALVRWTESVGLTLISR--DLASMQL 635

  Fly   518 RYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDT-IWLYSKGAESAIFPRCKASPLVEQTD--- 578
            :.||.:.:.:..|.:..|:||.:||.:||||:|.. |..|.|||:.|:      |.:|:..|
Mouse   636 KTPSGQVLTYCILQMFPFTSESKRMGIIVRDESTAEITFYMKGADVAM------STIVQYNDWLE 694

  Fly   579 AQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATA 643
            .:....|:.||||:.|.:|.||:::...||..|.:|...:.:|...:|:..|::|.|::||..|.
Mouse   695 EECGNMAREGLRTLVVAKRTLTEEQYQDFESRYSQAKLSIHDRALKVAAVVESLEREMELLCLTG 759

  Fly   644 LEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLAR 708
            :||.||..|..|||.|:.||:|||:|||||:|||..|..:...:.|....|.....|...|....
Mouse   760 VEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHVFRPVTSRGEAHLE 824

  Fly   709 LDMIGDDEPEVLIVDGTTITALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYIT 773
            |:.........|::.|.::...|.:...:..:||.:|.||:|||.||.||:.||||:::..:..|
Mouse   825 LNAFRRKHDCALVISGDSLEVCLRYYEHELVELACQCPAVVCCRCSPTQKAHIVTLLRQHTRKRT 889

  Fly   774 AAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLF 838
            .|||||.|||||||.|..||||.|:|||||:..|||||.:|..:.||.:|||..:.:|.|.|..|
Mouse   890 CAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQF 954

  Fly   839 YCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPEL 903
            ..::.:||:...|::.....:::..:|....:..:..:|..|....| :.|:|...|..:.:|||
Mouse   955 VMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSL-VLDQDVKPEMAILYPEL 1018

  Fly   904 YKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVI 968
            ||.|...|..|...|.:|:|....|..|:.:....:..|           .|.....:..|.:::
Mouse  1019 YKDLTKGRSLSFKTFLIWVLISIYQGGILMYGALLLFED-----------EFVHVVAISFTALIL 1072

  Fly   969 VGNLKLLLVAHYMTYRNFAMILA---SIAAFMLTTYLYNLY------TSGELYDVYNQFLSSLP- 1023
            .   :||:||..:...::.|::|   |:..::.:....|.|      :.|...||  .|::::.
Mouse  1073 T---ELLMVALTIRTWHWLMVVAEFLSLGCYVASLAFLNEYFGIGRVSFGAFLDV--AFITTVTF 1132

  Fly  1024 IWLFTIICSVACLLPDFVIKVVNDMYRKV--PLKSK 1057
            :|..:.|..|:| ||.:|:|.:.   ||:  |..||
Mouse  1133 LWKVSAITVVSC-LPLYVLKYLK---RKLSPPSYSK 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	17/46 (37%)
		ATPase-Plipid	28..1051	CDD:273734	324/1107 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	34/130 (26%)
		Cation_ATPase	<489..568	CDD:289987	30/80 (38%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	62/255 (24%)
Atp9b	XP_006526569.1	P-type_ATPase_APLT_Neo1-like	131..1076	CDD:319841	303/1022 (30%)
Atp9b	XP_006526569.1	Cation_ATPase	596..680	CDD:372530	33/93 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920