DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp11a

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_056619.1	Gene:	Atp11a / 50770	MGIID:	1354735	Length:	1187	Species:	Mus musculus

Alignment Length:	1132	Identity:	400/1132 - (35%)
Similarity:	610/1132 - (53%)	Gaps:	136/1132 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ADKKKSADPLRIQIG------GIES--RQQKPLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLI 59
            |.::...|...|.:|      |.|:  .|:.|.||:.::|||::.|:|.|.:|||||...|||||
Mouse    15 AGEENWVDSRTIYVGHKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLI 79

  Fly    60 ITIVSFFVNETISPLVSLLPLLFVMIITALKEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQ 124
            |.:|...::...||:.|.|||.||:.:||:|:|.||:.|.|:|..:|...|..|::||.....|:
Mouse    80 IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSR 144

  Fly   125 FIVPGDLVVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGETNLKTICVPTNYLL---AGDHEL 186
            .:..||:|:|:.|...||||:.|.|:.||..|.|.||:||||::.|     |:|.:   .|.|..
Mouse   145 KLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHK-----THYAVQDTKGFHTE 204

  Fly   187 QGKD----CIVCEPSSADLYTFNGRLELRSG-NDGAGSSAGDALPLTIDNLLLRGVRVKSTERVV 246
            ...|    .|.||....|||.|.||:.:.:. ||..      ..||..:||||||..:|:||::.
Mouse   205 ADVDSLHATIECEQPQPDLYKFVGRINVYNDLNDPV------VRPLGSENLLLRGATLKNTEKIF 263

  Fly   247 GCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMV---ALIVGMIVVVVVLYLIERHKEAKIVPT 308
            |.||||||.||:.||.:....|.::.||.:|.|::   .::|...::..||..:.:.:
Mouse   264 GVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSE------- 321

  Fly   309 MPYQGPP---------TNFNSAWQIFEDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHL 364
             |::..|         ...|...:.|.|||:|::||||::|:|.|:.:|:.:..|.:|:..|..:
Mouse   322 -PFRDEPWYNEKTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDM 385

  Fly   365 YDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEG--T 427
            :|||..:...||.|:||||||||..:|:|||||||:|.|.|..|.:.|..|.   .|::..|  .
Mouse   386 FDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVYV---PHVICNGQVL 447

  Fly   428 DEKFELEKLDADAAV--------LFEALAVCHTVEVLQE-VGDKTLESSESVSEQSHLMSRNIVD 483
            .:...::.:|:...|        .|.|:.:||||:|..: .||......:|...:|.:
Mouse   448 PDSSGIDMIDSSPGVCGREREELFFRAICLCHTVQVKDDHCGDDVDGPQKSPDAKSCV------- 505

  Fly   484 RYQASSPDEKALLEGCASLGLVY----------EGQENDVLSICRYPSAEKVQFKRLHVLEFSSE 538
             |.:|||||.||:||...||..|          ..:|||:           .:|:.|.||.|.|.
Mouse   506 -YISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENDI-----------ERFELLEVLTFDSV 558

  Fly   539 RQRMSVIVRDQSDTIWLYSKGAESAIFPRCKASPLVEQTDAQITKYAQNGLRTMAVGRRMLTDDE 603
            |:||||||:..:..|:|:.|||:|:||||. ....|:|..:::.:.|..||||:.|..:.|..::
Mouse   559 RRRMSVIVKSTTGEIYLFCKGADSSIFPRV-IEGKVDQVRSRVERNAVEGLRTLCVAYKRLEPEQ 622

  Fly   604 LFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWV 668
            ......|.:.|...|.:|.:.:|..||.:|.:|.||||||:||.|||...:|:||||.||:|:||
Mouse   623 YEDACRLLQSAKVALQDREKKLAEAYEQIEKDLVLLGATAVEDRLQEKAADTIEALQKAGIKVWV 687

  Fly   669 LTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDMIGDDEPEV-------------- 719
            |||||:|||.....||:...|.::  .:..||:..|..:..|::.|....|
Mouse   688 LTGDKMETASATCYACKLFRRSTQ--LLELTTKKLEEQSLHDVLFDLSKTVLRCSGSMTRDSFSG 750

  Fly   720 ---------LIVDGTTITALLEHTPRQ-----------FADLALRCRAVLCCRLSPLQKSEIVTL 764
                     ||:||..::.:::  ||:           |.::...|.||||||::||||::||.|
Mouse   751 LSTDMHDYGLIIDGAALSLIMK--PREDGSSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKL 813

  Fly   765 IKRRKKY-ITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYN 828
            ||..|:: ||.||||||||||||.|||:|||:.|:||:||||.:|::|.:|:.|:::.|||||:.
Mouse   814 IKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFY 878

  Fly   829 SQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYS 893
            ..|::.||.::.|||:.......|||.:..:|...:|::.||.|::|.:.|....:.::.::...
Mouse   879 YIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVG 943

  Fly   894 EETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTF 958
            .:.|...|.||:.:|.|......||..|...|.....:.||..|.:..:..|..||....:: ||
Mouse   944 IDVLKRDPTLYRDIAKNALLRWRVFIYWTFLGVFDALVFFFGAYFIFENTTVTINGQMFGNW-TF 1007

  Fly   959 GTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYN-----LYTSGELYDVYNQF 1018
            ||::.|::|:...|||.|..||.|:.|..:|..|:..::..:.|:.     ..:...:|.|:...
Mouse  1008 GTLVFTVMVLTVTLKLALDTHYWTWINHFVIWGSLLFYIAFSLLWGGVIWPFLSYQRMYYVFISM 1072

  Fly  1019 LSSLPIWLFTIICSVACLLPDFVIKVV 1045
            |||.|.||..|:.....||||.:.||:
Mouse  1073 LSSGPAWLGIILLVTVGLLPDVLKKVL 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	23/47 (49%)
		ATPase-Plipid	28..1051	CDD:273734	392/1099 (36%)
		E1-E2_ATPase	84..>189	CDD:278548	41/107 (38%)
		Cation_ATPase	<489..568	CDD:289987	36/88 (41%)
		HAD_like	<758..807	CDD:304363	34/49 (69%)
		PhoLip_ATPase_C	804..1050	CDD:292829	75/247 (30%)
Atp11a	NP_056619.1	P-type_ATPase_APLT_Dnf-like	47..986	CDD:319770	356/984 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835004
Domainoid	1	1.000	215	1.000	Domainoid score	I2701
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	804	1.000	Inparanoid score	I495
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	1	1.000	-	-		FOG0004283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770