DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9981 and ATP12A

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001172014.1	Gene:	ATP12A / 479	HGNCID:	13816	Length:	1045	Species:	Homo sapiens

Alignment Length:	921	Identity:	192/921 - (20%)
Similarity:	349/921 - (37%)	Gaps:	244/921 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 VMIITALKEGLEDYSRSKSDKLVNT------ARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVP 141
            |:|:|.:   ...|..:||..::::      .:..|||:.:::.|.|:.:|.||:|.|:....:|
Human   154 VVILTGI---FAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIP 215

  Fly   142 CDLVLLQSSSADRKCFVNTANLDGETNLKTICVPTNYLLAGDHELQGKDCIVCEPSSADLYTFNG 206
            .|:.:|.|..    |.|:.::|.||:..:    |.:.....::.|:.|:  :|..|:..|
Human   216 ADIRVLSSQG----CRVDNSSLTGESEPQ----PRSSEFTHENPLETKN--ICFYSTTCL----- 265

  Fly   207 RLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKL----QLNSRYTGN 267
                    :.:.|..|                     .|.|..|.||..|.:    .|.|. .||
Human   266 --------EASTSPVG---------------------TVTGMVINTGDRTIIGHIASLASG-VGN 300

  Fly   268 KSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFED--FLS 330
            :.......|..| |.::.|:.|.:.:|:.|       |..::.|           |:.:.  ||.
Human   301 EKTPIAIEIEHF-VHIVAGVAVSIGILFFI-------IAVSLKY-----------QVLDSIIFLI 346

  Fly   331 FLLLFN----YMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILF 391
            .:::.|    .:..::..:::...|:                ..:.|.|......|.||..:|:.
Human   347 GIIVANVPEGLLATVTVTLSLTAKRM----------------AKKNCLVKNLEAVETLGSTSIIC 395

  Fly   392 SDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDADA---AVLFEALAVCHTV 453
            ||||||||:|.|...:.:       ..|...|:: |.|....:..|..:   |.|.:.:.:|:..
Human   396 SDKTGTLTQNRMTVAHLW-------FDNQIFVAD-TSEDHSNQVFDQSSRTWASLSKIITLCNRA 452

  Fly   454 EVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLE-GCASLGLVYE-GQENDVLSI 516
            |.            :...|...:|.:.::     ....|.|||: ....||.|.| .:.|..::.
Human   453 EF------------KPGQENVPIMKKAVI-----GDASETALLKFSEVILGDVMEIRKRNRKVAE 500

  Fly   517 CRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRC-------KASPLV 574
            ..:.|..|.|.. :|.::....::.:.|:            |||...|..:|       :..||.
Human   501 IPFNSTNKFQLS-IHEMDDPHGKRFLMVM------------KGAPERILEKCSTIMINGEEHPLD 552

  Fly   575 EQTDAQI-TKYAQNGLRTMAVGRRMLTDDELF----HFEELYRKANTQLSNRNELIASCYETVEN 634
            :.|.... |.|.:.|    .:|.|:|....|:    .|.|.|         ..::.|..:.|  :
Human   553 KSTAKTFHTAYMELG----GLGERVLGFCHLYLPADEFPETY---------SFDIDAMNFPT--S 602

  Fly   635 ELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIIN- 698
            .|..:|..::.|..:..|.:.:...::||:|:.::|||...||..|          :|...||:
Human   603 NLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAI----------AKSVGIISA 657

  Fly   699 TTEPAELLAR-----LDMIGDDEPEVLIVDGTTITALLEHTPRQFADLALRCRAVLCCRLSPLQK 758
            .:|..|.:|.     ::.:...:.:..:|.|   ..|.:.:..|..::....:.::..|.||.||
Human   658 NSETVEDIAHRLNIAVEQVNKRDAKAAVVTG---MELKDMSSEQLDEILANYQEIVFARTSPQQK 719

  Fly   759 SEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGI--GITGREGKQAARCADFSIARFEMLRRLF 821
            ..||...:|:.. :.|..|||.||...:::|.|||  ||.|.:.  |...||           :.
Human   720 LIIVEGCQRQDA-VVAVTGDGVNDSPALKKADIGIAMGIAGSDA--AKNAAD-----------MV 770

  Fly   822 LVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYD------LYSAT-NVYNSIYLWLFDIVYIS 879
            |:..::.|               |:||......::|      .||.| |:.......::.||.:.
Human   771 LLDDNFAS---------------IVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLP 820

  Fly   880 FSFTVLAICDKDYSEETLLSHPELY----------KPLAHNR----QASMGVFSLWILNGFVQ-- 928
            .....:.|...|...:.:.|....|          ||...|:    ...:.|:| ::..|.:|
Human   821 LPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYS-YLHIGLMQAL 884

  Fly   929 -CFIIFFFTYA 938
             .|:::|..||
Human   885 GAFLVYFTVYA 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826
		ATPase-Plipid	28..1051	CDD:273734	192/921 (21%)
		E1-E2_ATPase	84..>189	CDD:278548	26/110 (24%)
		Cation_ATPase	<489..568	CDD:289987	18/80 (23%)
		HAD_like	<758..807	CDD:304363	18/50 (36%)
		PhoLip_ATPase_C	804..1050	CDD:292829	29/159 (18%)
ATP12A	NP_001172014.1	ATPase-IIC_X-K	42..1045	CDD:273445	192/921 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910