DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and ATP9B

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_011524265.1	Gene:	ATP9B / 374868	HGNCID:	13541	Length:	1174	Species:	Homo sapiens

Alignment Length:	1113	Identity:	329/1113 - (29%)
Similarity:	530/1113 - (47%)	Gaps:	138/1113 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KKKSADPLRIQIGGIESRQQK-PLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN 68
            :||......:.:|..|..::| |.|.:...||..|||:|...||||:..:..|||:|:...|...
Human   110 RKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPA 174

  Fly    69 ETISPLVSL-LPLLFVMIITALKEGLEDYSRSKSDKLVNT---ARVTVIRNGKEEIINSQFIVPG 129
            ..|..|.:. .||.||:.:|..:|.::::.|.:.||.||:   :::||  .||.::.:|...| |
Human   175 LKIGYLYTYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTV--RGKVQVKSSDIQV-G 236

  Fly   130 DLVVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGETN--LKTICVPTNYLLAGDHELQGKDCI 192
            ||::|..:..:|.|:|.|::|.....||:.|..|||||:  ||.....|..|.|..........:
Human   237 DLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKVAVSCTQQLPALGDLFSISAYV 301

  Fly   193 VCEPSSADLYTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTK 257
            ..:....|:::|.|.......:.....|      |:|:|.|.....|.| ..|:|..||||..|:
Human   302 YAQKPQMDIHSFEGTFTREDSDPPIHES------LSIENTLWASTIVAS-GTVIGVVIYTGKETR 359

  Fly   258 LQLNSRYTGNKSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAW 322
            ..:|:....||....:..:||...||.:.::.:.:|:           |....:.||       |
Human   360 SVMNTSNPKNKVGLLDLELNRLTKALFLALVALSIVM-----------VTLQGFVGP-------W 406

  Fly   323 QIFEDFLSFLLLFNYMVPISAYMNIEVYR-IFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQ 386
              :.:...|||||:|::|||..:|:::.: ::|...|       .:|......|..|.:.||||:
Human   407 --YRNLFRFLLLFSYIIPISLRVNLDMGKAVYGWMMM-------KDENIPGTVVRTSTIPEELGR 462

  Fly   387 VNILFSDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEKFE---------------LEKL 436
            :..|.:|||||||:|.|.|...::...:|.......:.....:.:.               |.|.
Human   463 LVYLLTDKTGTLTQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKA 527

  Fly   437 DADAAVL-----------FEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSP 490
            .:.|..:           .:|:.:||.|..:.|......|.:|...........|  ..||||||
Human   528 QSSAPKVRKSVSSRIHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDEN--RTYQASSP 590

  Fly   491 DEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDT-IW 554
            ||.||::...|:||....::...:.: :.||.:.:.|..|.:..|:||.:||.|||||:|.. |.
Human   591 DEVALVQWTESVGLTLVSRDLTSMQL-KTPSGQVLSFCILQLFPFTSESKRMGVIVRDESTAEIT 654

  Fly   555 LYSKGAESAIFPRCKASPLVEQTD---AQITKYAQNGLRTMAVGRRMLTDDELFHFEEL------ 610
            .|.|||:.|:      ||:|:..|   .:....|:.||||:.|.::.||:::...||.:
Human   655 FYMKGADVAM------SPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFEPMQSSSVE 713

  Fly   611 --------------------YRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGET 655
                                |.:|...:.:|:..:|:..|::|.|::||..|.:||.||..|..|
Human   714 STHSTYTCAHRRLPLCPQSRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGVEDQLQADVRPT 778

  Fly   656 LEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDMIGDDEPEVL 720
            ||.|:.||:|||:|||||:|||..|..:...:.|....|.....|...|....|:.........|
Human   779 LEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNAFRRKHDCAL 843

  Fly   721 IVDGTTITALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSM 785
            ::.|.::...|::...:|.:||.:|.||:|||.||.||:.||||:::.....|.|||||.|||||
Human   844 VISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSM 908

  Fly   786 IQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCM 850
            ||.|..||||.|:|||||:..|||||.:|..:.||.:|||..:.:|.|.|..|..::.:||:...
Human   909 IQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQ 973

  Fly   851 ALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASM 915
            |::.....:::..:|....:..:..:|..|....| :.|:|...|..:.:|||||.|...|..|.
Human   974 AVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSL-VLDQDVKPEMAMLYPELYKDLTKGRSLSF 1037

  Fly   916 GVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHY 980
            ..|.:|:|....|..|:.:       .|.|||.    :.|.....:..|.:::.   :||:||..
Human  1038 KTFLIWVLISIYQGGILMY-------GALVLFE----SEFVHVVAISFTALILT---ELLMVALT 1088

  Fly   981 MTYRNFAMILA---SIAAFMLTTYLYNLY------TSGELYDVYNQFLSSLP-IWLFTIICSVAC 1035
            :...::.|::|   |:..::.:....|.|      :.|...||  .|::::. :|..:.|..|:|
Human  1089 VRTWHWLMVVAEFLSLGCYVSSLAFLNEYFGIGRVSFGAFLDV--AFITTVTFLWKVSAITVVSC 1151

  Fly  1036 LLPDFVIK 1043
             ||.:|:|
Human  1152 -LPLYVLK 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/46 (39%)
		ATPase-Plipid	28..1051	CDD:273734	323/1089 (30%)
		E1-E2_ATPase	84..>189	CDD:278548	35/109 (32%)
		Cation_ATPase	<489..568	CDD:289987	30/79 (38%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	65/250 (26%)
ATP9B	XP_011524265.1	PhoLip_ATPase_N	125..182	CDD:292826	21/56 (38%)
		ATPase-Plipid	132..1169	CDD:273734	324/1091 (30%)
		E1-E2_ATPase	224..427	CDD:278548	64/230 (28%)
		Cation_ATPase	579..661	CDD:289987	33/84 (39%)
		HAD_like	<881..922	CDD:304363	24/40 (60%)
		PhoLip_ATPase_C	927..1166	CDD:292829	65/250 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920