DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp10a

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001135407.1	Gene:	Atp10a / 365266	RGDID:	1306150	Length:	1508	Species:	Rattus norvegicus

Alignment Length:	1274	Identity:	370/1274 - (29%)
Similarity:	573/1274 - (44%)	Gaps:	286/1274 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFF--VNETISPLVSLLPLLFVMIITALK 90
            ||:.|||||..:|||.|.:|||.|....||:.|.:::|.  || ...|:::|.|:||::.:||:|
  Rat    66 NRLKTTKYTLLSFLPKNLFEQFHRLANVYFVFIALLNFVPAVN-AFQPVLALAPVLFILAVTAIK 129

  Fly    91 EGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQF--IVPGDLVVVRNDGDVPCDLVLLQSSSAD 153
            :..|||||.:||..:|.....|....:::.:|..:  |..||.|.:..:..:|.|::||.||..|
  Rat   130 DLWEDYSRHRSDHEINHLGCLVFSREEKKYVNRYWKEIRVGDFVRLCCNEIIPADILLLSSSDPD 194

  Fly   154 RKCFVNTANLDGETNLKTICVPTNY--LLAGDHELQGKDCIVCEPSSADLYTFNGRLELRSGNDG 216
            ..|.:.|||||||||||...|...:  |::..:.|.....|.||..:.||..|.|.: :.|..:.
  Rat   195 GLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGCI-IHSNGEK 258

  Fly   217 AGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMV 281
            ||        |..:||||||..:::||.|.|..||.|..||..||:.....|.:..|:.:|..::
  Rat   259 AG--------LHKENLLLRGCTIRNTEAVAGIVIYAGHETKALLNNSGPRYKRSQLERQMNCDVL 315

  Fly   282 ALIVGMIVVVVVLY-------LIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMV 339
            ..:  :::|.:.|:       .:.|::|.|.:..:| :...::.:.|......||:.:::...::
  Rat   316 WCV--LLLVCISLFSAVGHGLWVRRYQEKKALFDVP-ESDGSSLSPATAAVYSFLTMIIVLQVLI 377

  Fly   340 PISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMK 404
            |||.|::||:.::..::|::.|:.|||||||...:..|.|:.|:|||:..:|||||||||:|.|.
  Rat   378 PISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNITEDLGQIKYIFSDKTGTLTENKMV 442

  Fly   405 FVNCYVPGTNY---------------------------------------QLQNTH--------- 421
            |..|.|.|..|                                       .:..||
  Rat   443 FRRCTVSGIEYSHDANAQRLAKYQEADSEEEEMVSKVGPISHRGSTGSHQSIWMTHKTQSIKSHR 507

  Fly   422 ------------LVSEGT------------DEKFELEKLD-----------------------AD 439
                        ::|:.|            |.|. |||:.                       :|
  Rat   508 RTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKL-LEKVSECDRFLSIARHQEHPLAHLSPELSD 571

  Fly   440 AAVLFEALAVCHTVEV--------------------------------------LQEVGDKTLES 466
            ....|.||.:|:||.|                                      ...:|:.|...
  Rat   572 VFDFFIALTICNTVVVTSPDQPRQKVRVRFELKSPVKTIEDFLRKFTPSRLASGCSSIGNLTNNK 636

  Fly   467 SESVSEQSHLMSRNIVD------------------------------------------------ 483
            |.:.|..:.|.|.:..:
  Rat   637 SSNKSGSTFLPSLSQDNMLLRLEERLGQTAPVIASNGYASQASQAESWTSECTSEQKCPGDQREQ 701

  Fly   484 -----RYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMS 543
                 ||:|.||||.||:....:.......:.:|.:|: ..|...::.|:.||.|.|.|.|:|||
  Rat   702 QEGELRYEAESPDEAALVYAAKAYNCALVDRLHDQVSV-ELPHLGRLTFELLHTLGFDSIRKRMS 765

  Fly   544 VIVRDQ-SDTIWLYSKGAESAIFP---RCKA--------SPLVEQTDAQITKYAQNGLRTMAVGR 596
            |::|.. :|.|.:|:|||:|.:..   .|.:        ..:..:|...:..||..||||:.:.:
  Rat   766 VVIRHPLTDEINVYTKGADSVVMDLLLPCSSDDARGRHQKKIRSKTQNYLNLYAVEGLRTLCIAK 830

  Fly   597 RMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEALQA 661
            |:|:.:|...:.:.:.:|.|.:.:|.||:......:|..|.|||||.:||.||:.|.||:..|:.
  Rat   831 RVLSKEEYACWLQSHIEAETSVESREELLFQSAVRLETNLHLLGATGIEDRLQDGVPETIAKLRQ 895

  Fly   662 AGLKIWVLTGDKVETAYNIGLAC------------------------------------RHIPRG 690
            |||:||||||||.|||.||..||                                    |.:|:.
  Rat   896 AGLQIWVLTGDKQETAINIAYACKLLDHGEEVITLNADSREACAALLDQCLCYVQSRNSRSVPQN 960

  Fly   691 SKQHFIIN-TTEPAELLARLDMIGDDEPE-VLIVDGTTITALLEHT-PRQFADLALRCRAVLCCR 752
            |:..|.:. :..||....      |..|. .|::||.::...||.: ..:|..||.:||:|||||
  Rat   961 SESSFSVGFSFNPASTST------DSSPSPSLVIDGRSLAYALEKSLEDKFLFLAKQCRSVLCCR 1019

  Fly   753 LSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEML 817
            .:|||||.:|.|::.:.|.:|.|||||||||||||.|.:|:||:|:||.||...:||::.||..|
  Rat  1020 STPLQKSMVVKLVRNKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPRFRYL 1084

  Fly   818 RRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSF 882
            .||.:||||:...|||.:||::.|||.:..|.:..:|.|..:||:.:.:..||..|::::.|...
  Rat  1085 ERLLIVHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFYCGFSASAMIDQWYLIFFNLLFSSLPQ 1149

  Fly   883 TVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANV-L 946
            .|..:.|||...:.||..|:|||...:..:.|...|.|.:::...|..:.||..|....|::| :
  Rat  1150 LVTGVLDKDVPADMLLRKPQLYKSGQNMEEYSPRAFWLNMVDAAFQSLVCFFIPYLAYYDSDVDV 1214

  Fly   947 FNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYN-----LY 1006
            |         |:||.:..|.:....|.|.:.....|:.|:.....|...|.....:||     .|
  Rat  1215 F---------TWGTPVTAIALFTFLLHLGIETKTWTWLNWLACGFSTFLFFSVALIYNTSCATCY 1270

  Fly  1007 TSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVV 1045
            .....|......|.....:|..:|..||.|||....|.:
  Rat  1271 PPSNPYWTMPTLLGDPLFYLTCLIAPVAALLPRLFFKAL 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/37 (49%)
		ATPase-Plipid	28..1051	CDD:273734	370/1274 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	39/108 (36%)
		Cation_ATPase	<489..568	CDD:289987	28/82 (34%)
		HAD_like	<758..807	CDD:304363	28/48 (58%)
		PhoLip_ATPase_C	804..1050	CDD:292829	71/248 (29%)
Atp10a	NP_001135407.1	P-type_ATPase_APLT_Dnf-like	65..1203	CDD:319770	343/1157 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920