DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp11b

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_038959540.1	Gene:	Atp11b / 361929	RGDID:	1561719	Length:	1175	Species:	Rattus norvegicus

Alignment Length:	1112	Identity:	415/1112 - (37%)
Similarity:	623/1112 - (56%)	Gaps:	97/1112 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGADKKKSADPLRIQI------GGIESRQQKPLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLI 59
            :|.|....:|...|.|      .|:.:.|:...||:.::|||.:.|:|.|.:|||||...|||||
  Rat     9 LGFDPPHQSDTRTIYIANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLI 73

  Fly    60 ITIVSFFVNETISPLVSLLPLLFVMIITALKEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQ 124
            |.:|...::...||:.|.|||.||:.:||:|:|.||:.|..||..||.|.|.|:|:|......|:
  Rat    74 IFLVQLMIDTPTSPITSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSK 138

  Fly   125 FIVPGDLVVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGETNLKT-ICVPTNYLLAGDHELQG 188
            .|..||:|.:..|...|.|||||.|...|..|.|.||:||||||||| :.||...:|.....|..
  Rat   139 NIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVSVPETAVLQTVANLDS 203

  Fly   189 KDCIV-CEPSSADLYTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYT 252
            ...:: |:...||||.|.||:.:....:..      ..||..::|||||.|:|:|:.:.|.|:||
  Rat   204 LIAVIECQQPEADLYRFMGRMIITQQMEEI------VRPLGPESLLLRGARLKNTKEIFGVAVYT 262

  Fly   253 GMHTKLQLNSRYTGNKSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPT- 316
            ||.||:.||.:....|.::.||.:|.|::..::.:|...::..:::...:|:.....|:....|
  Rat   263 GMETKMALNYKSKSQKRSAVEKSMNTFLIIYLIILISEAIISTILKYTWQAEEKWDEPWYNQKTE 327

  Fly   317 ---NFNSAWQIFEDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNAS 378
               |.:...:...|||:||:|:|:::|||.|:.:|:.:..|..|:..||.||.||:||..:||.|
  Rat   328 HQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTS 392

  Fly   379 NLNEELGQVNILFSDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEG----------------- 426
            :||||||||..:|:|||||||:|.|:|..|.:.|..||..|..||.||
  Rat   393 DLNEELGQVEYVFTDKTGTLTENEMQFRECSINGLKYQEINGKLVPEGPSPDSAEGNDPYLGSLS 457

  Fly   427 --------------TDEKFELEKLDADAAVLFEALAVCHTVEV----LQEVGDKTLESSESVSEQ 473
                          |..:.|.| |..:..:.|:|:::||||::    ...:||...:.:.:.::.
  Rat   458 HLSSSAHLTATSLRTSPESETE-LIKEHDLFFKAVSLCHTVQISNVQTDGIGDGPWQPNLAPTQL 521

  Fly   474 SHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSE 538
                      .|.|||||||||:|..|..|:::.|...:.:.:......|:  :|.||:|||.|:
  Rat   522 ----------EYYASSPDEKALVEAAARAGIIFIGISEETMEVKVLGRVER--YKLLHILEFDSD 574

  Fly   539 RQRMSVIVRDQSDTIWLYSKGAESAIFPRCKASPLVEQTDAQITKYAQNGLRTMAVGRRMLTDDE 603
            |:||||||:..|....|::|||||:|.|:|.... :.:|...:.::|..||||:.:..|..|.:|
  Rat   575 RRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGE-IAKTRIHVDEFALKGLRTLCIAYRQFTAEE 638

  Fly   604 LFHFEELYRK---ANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLK 665
               :|::.|:   |.|.|..|.|.:|..::.:|.:|.||||||:||.||:.|.||:|||:.||:|
  Rat   639 ---YEDVNRRLFEARTSLQRREEKLAGVFQYIEKDLVLLGATAVEDRLQDKVRETIEALRMAGIK 700

  Fly   666 IWVLTGDKVETAYNIGLACRHIPRGSKQHFIIN------TTEPAELLARLDMIGDDE--PEVLIV 722
            :|||||||.|||.::.|:|.|..|......:||      ..|....|||  .|.:|.  ...|:|
  Rat   701 VWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKSDSGCAEQLRQLAR--RITEDHVIQHGLVV 763

  Fly   723 DGTTITALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIK-RRKKYITAAIGDGANDVSMI 786
            |||:::..|....:.|.::...|.||||||::||||::::.||| ..:|.||.|:||||||||||
  Rat   764 DGTSLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMI 828

  Fly   787 QEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMA 851
            ||||:||||.|:||:||||.:|:::|||:.|.:|..||||:...|:|.||.::.|||:.......
  Rat   829 QEAHVGIGIMGKEGRQAARNSDYAVARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQF 893

  Fly   852 LYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMG 916
            |||.|.|:|...:|:|:||.|::|.:.|....:.::.::......|.|.|.||:.::.||..||.
  Rat   894 LYQFYCLFSQQTLYDSVYLTLYNICFTSLPVLIYSLLEQHIDPHVLQSKPTLYRDISKNRLLSMK 958

  Fly   917 VFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYM 981
            .|..|.:.||...||.||.:|.::.....|...||.....||||::.|::||...:|:.|..|:.
  Rat   959 AFLYWTVLGFSHAFIFFFGSYFLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFW 1023

  Fly   982 TYRNFAMILASIAAFMLTTYLYNLYTSG---------ELYDVYNQFLSSLPIWLFTIICSVACLL 1037
            |:.|..:...||..:    ::::|:..|         .:|.|:.|.|||...|...::..|:||.
  Rat  1024 TWINHLVTWGSIIFY----FIFSLFYGGILWPFLGSQNMYSVFIQLLSSGSAWFAILLMVVSCLF 1084

  Fly  1038 PDFVIKV 1044
            .|.|.||
  Rat  1085 VDVVKKV 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	21/45 (47%)
		ATPase-Plipid	28..1051	CDD:273734	408/1079 (38%)
		E1-E2_ATPase	84..>189	CDD:278548	47/105 (45%)
		Cation_ATPase	<489..568	CDD:289987	35/78 (45%)
		HAD_like	<758..807	CDD:304363	33/49 (67%)
		PhoLip_ATPase_C	804..1050	CDD:292829	83/250 (33%)
Atp11b	XP_038959540.1	P-type_ATPase_APLT_Dnf-like	41..978	CDD:319770	374/961 (39%)
Atp11b	XP_038959540.1	AA_permease_2	<959..>1085	CDD:424363	38/129 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	169	1.000	Domainoid score	I3703
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	743	1.000	Inparanoid score	I560
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.980