DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp10d

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_038948646.1	Gene:	Atp10d / 360932	RGDID:	1588541	Length:	1417	Species:	Rattus norvegicus

Alignment Length:	1290	Identity:	372/1290 - (28%)
Similarity:	588/1290 - (45%)	Gaps:	315/1290 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFF-VNETISPLVSLLPLLFVMIITALKE 91
            ||:.|||||...|:|.|.:|||.||...|||.:.::::. :.|.....:::|||:.|:.|.|:|:
  Rat    74 NRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKD 138

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNGKEEIINS--QFIVPGDLVVVRNDGDVPCDLVLLQSSSADR 154
            |||||.:.|.||.:|.....|....:::.|:.  :.:..||.:.:..:..:|.|:|||.|:..|.
  Rat   139 GLEDYRKYKIDKQINNLITKVYSRKEKKYIDCCWKNVTVGDFIRLSCNEIIPADMVLLFSTDPDG 203

  Fly   155 KCFVNTANLDGETNLKTICVPTNYLLAGDHELQGK---DCIVCEPSSADLYTFNGRLELRSGNDG 216
            .|.:.|:.||||:|||...|...| ...|.|:..:   ..|.||..:.||..|.|.|| .|..:.
  Rat   204 ICHIETSGLDGESNLKQRQVVRGY-AEQDSEVDPEKFSSRIECESPNNDLSRFRGFLE-HSNKER 266

  Fly   217 AGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMV 281
            .|        |:.:||||||..:::||.|||..:|.|..||..||:.....|.:..|:..|..::
  Rat   267 VG--------LSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVL 323

  Fly   282 ALIVGMIVVVV---------------VLYLIERHKEAKIV-PTMPYQGPPTNFNSAWQIFEDFLS 330
            ..::.:||:.:               :|:......:.::: |.:      |.|...|       :
  Rat   324 WCVLLLIVMCLTGALGHGIWLSRYENMLFFNIPEPDGRVLSPVL------TGFYVFW-------T 375

  Fly   331 FLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKT 395
            .::|...::|||.|::||:.::..::|:.:|:..|:|:.|...:..|.|:.|:|||:..||||||
  Rat   376 MIILLQVLIPISLYVSIEIVKLGQIYFIQSDVEFYNEKMDSTIQCRALNITEDLGQIQYLFSDKT 440

  Fly   396 GTLTKNLMKFVNCYVPGTNY--------------------------------------------- 415
            ||||:|.|.|..|.|.|.:|
  Rat   441 GTLTENKMVFRRCSVAGFDYCHEENAKRLESYQEAVSEEEECTDTLSGSLSLGSVARPRAQSCRT 505

  Fly   416 -----------QLQ-NTHLVSEG-------------------TD--------EKFE------LEK 435
                       ||. :|..|..|                   ||        :||.      ..:
  Rat   506 AHSRLPGKPLAQLSGSTSAVGNGEGSGEVLHSRQAAFSSPIETDVVPDTRLLDKFSQITPQLFTR 570

  Fly   436 LD--ADAAVL--------FEALAVCHTVEV------LQEVGDKTL-------------------- 464
            ||  |.:|.|        |.|||:|:||.|      .|::|..:|
  Rat   571 LDGAAQSAPLETLYIMDFFIALAICNTVVVSAPNQPRQKIGLSSLGGMPIKSLEEIKNIFQKLSV 635

  Fly   465 ----------------------------------------ESS---------------ESVSEQS 474
                                                    |||               ||.:|.|
  Rat   636 RRSSSPSLASGKDSTSGTPCAFVSRISFFSRTKLSPPVEDESSQMDEIPQASNSACCTESEAENS 700

  Fly   475 HL---------------MSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEK 524
            .:               ::.|:.  |:|.||||.||:....:.......:..:.: :..:.:...
  Rat   701 DVGLPIDSAEALDGPPPLASNLC--YEAESPDEAALVYAARAYHCTLRSRTPEQV-VVDFAALGP 762

  Fly   525 VQFKRLHVLEFSSERQRMSVIVRDQ-SDTIWLYSKGAESAIFPRCKASP------------LVEQ 576
            :.|:.||:|.|.|.|:||||:||.. |..:.:|:|||:|.|......:.            :.|:
  Rat   763 LTFQLLHILPFDSVRKRMSVVVRHPLSKQVVVYTKGADSVIMELLSVASSDGTNLEDQQMVIRER 827

  Fly   577 TDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGA 641
            |...:.:||:.||||:.|.:::::|.|...:...:..|.|.:.||.||:......:||:|.||||
  Rat   828 TQRHLDEYAKRGLRTLCVAKKVMSDTEYAEWLRNHFLAETSIDNREELLVESAMRLENKLTLLGA 892

  Fly   642 TALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINT-TEPA-- 703
            |.:||.|||.|.|::|||..||:|||:|||||.|||.||..||:.:....|. ||:|| :|.|
  Rat   893 TGIEDRLQEGVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKL-FILNTQSEDACG 956

  Fly   704 --------ELLARLDMIGD-----------DEPEV-----LIVDGTTIT-ALLEHTPRQFADLAL 743
                    ||..|..:..:           .:|:|     |::.|.|:. ||.|...:||.:|..
  Rat   957 MLMSAILEELQKRTQVSPELASPRKNFPQPPDPQVPGRAGLVITGKTLEFALQESLQKQFLELTA 1021

  Fly   744 RCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCAD 808
            .|:||:|||.:||||||:|.|::.....:|.|||||||||||||.|.||||::|:||.||...:|
  Rat  1022 WCQAVICCRATPLQKSEVVKLVRNHLHVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQAVMASD 1086

  Fly   809 FSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLF 873
            |:|::|..|.:|.|||||:...||:.::|::.|||:.....:..||.:..:|.|::.:...|..|
  Rat  1087 FAISQFRHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFF 1151

  Fly   874 DIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQ---CFIIFFF 935
            ::::.|....:..:.:||.|.||||..||||:....:.:.....|.:.:|:.|.|   ||.:.:|
  Rat  1152 NLLFTSVPPIIYGVLEKDVSAETLLQLPELYQSGQRSEEYLPLTFWITLLDAFYQSLVCFFVPYF 1216

  Fly   936 TYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTT 1000
            ||.           |......|||..|.|..:::..|.|::.:..:|:.:..:|:.||     .:
  Rat  1217 TYQ-----------GSDIDIFTFGNPLNTAALLIILLHLVIESKSLTWIHMLVIVGSI-----LS 1265

  Fly  1001 YLYNLYTSGEL----------YDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVV 1045
            |.:.....|.|          |.:..:.:.....:|..::.:...|||.||.:|:
  Rat  1266 YFFFALAFGALCVTCNPPSNPYGIMQKHMLDPVFYLVCVLTTCVALLPRFVYRVL 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/37 (49%)
		ATPase-Plipid	28..1051	CDD:273734	372/1290 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	36/106 (34%)
		Cation_ATPase	<489..568	CDD:289987	26/79 (33%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	67/255 (26%)
Atp10d	XP_038948646.1	P-type_ATPase_APLT_Dnf-like	73..1214	CDD:319770	346/1166 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940