DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9981 and ATP13A5

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_940907.2	Gene:	ATP13A5 / 344905	HGNCID:	31789	Length:	1218	Species:	Homo sapiens

Alignment Length:	1132	Identity:	231/1132 - (20%)
Similarity:	394/1132 - (34%)	Gaps:	343/1132 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YFYFLIITIVSFFVNETISPLVSLLPLLFVMIITALKEGLEDYSRSKSDKL------VNTARVTV 112
            ::.|...|:..:.....|...|:::.|..:.|:.::.:     .|.:|.||      .|..:||:
Human   207 FYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYD-----LRQQSVKLHNLVEDHNKVQVTI 266

  Fly   113 I--RNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGETNLKTICVP 175
            |  ..|.|| :.|:.:||||::::.....:|||.||:     |..|.||...|.||:      :|
Human   267 IVKDKGLEE-LESRLLVPGDILILPGKFSLPCDAVLI-----DGSCVVNEGMLTGES------IP 319

  Fly   176 T---------NYLLAGDHELQ---------GKDCIVCEPSSADLYTFNGRLELRSGNDGAGSSAG 222
            .         |.:....|.|:         |.:.|..:||.      .|.:.......|..::.|
Human   320 VTKTPLPQMENTMPWKCHSLEDYRKHVLFCGTEVIQVKPSG------QGPVRAVVLQTGYNTAKG 378

  Fly   223 DALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMVALIVGM 287
            |         |:|.:            :|.               :..:.:.|.:.|...:.:..
Human   379 D---------LVRSI------------LYP---------------RPLNFKLYSDAFKFIVFLAC 407

  Fly   288 IVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSF-LLLFNYMVP----------- 340
            :.|:...|.:..:.         |.|.|.         :|.::. |:|....||
Human   408 LGVMGFFYALGVYM---------YHGVPP---------KDTVTMALILLTVTVPPVLPAALTIGN 454

  Fly   341 ISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKF 405
            :.|...::..:||.:               .|.|:|.      .||:|::..|||||||::.:..
Human   455 VYAQKRLKKKKIFCI---------------SPQRINM------CGQINLVCFDKTGTLTEDGLDL 498

  Fly   406 VNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDADAAVLFEALAVCHTVEVLQEV--GD----KTL 464
            ... ||..:...|..|..:.|....:         :.|..|:|.||::.:|...  ||    |..
Human   499 WGT-VPTADNCFQEAHSFASGQAVPW---------SPLCAAMASCHSLILLNGTIQGDPLDLKMF 553

  Fly   465 ESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKR 529
            |.:      :..|...|||..:..:.....:..|..:.....|.    ::::|::|
Human   554 EGT------AWKMEDCIVDSCKFGTSVSNIIKPGPKASKSPVEA----IITLCQFP--------- 599

  Fly   530 LHVLEFSSERQRMSVIVRDQSDT-IWLYSKGAESAIFPRCKASPLVEQTDAQITKYAQNGLRTMA 593
                 |||..||||||.:...:. ..:|.|||...:...|::..:.:....::..|...|.|.:|
Human   600 -----FSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELRSYTVQGFRVIA 659

  Fly   594 VGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEA 658
            :..:.|....|...|.|.|                 |.||:||..||...:|:.|::.....|:.
Human   660 LAHKTLKMGNLSEVEHLAR-----------------EKVESELTFLGLLIMENRLKKETKLVLKE 707

  Fly   659 LQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAEL--------LARLDMIGDD 715
            |..|.::..::|||.::||..:......||.|| |..|:...||.|.        |......|..
Human   708 LSEARIRTVMITGDNLQTAITVAKNSEMIPPGS-QVIIVEADEPEEFVPASVTWQLVENQETGPG 771

  Fly   716 EPEVLIVDGTTIT-------------------ALLEHTPRQFADL--ALRCRAVLCCRLSPLQKS 759
            :.|:.:..|.:.|                   .:.:|    |..|  .:.....:..|:||.|||
Human   772 KKEIYMHTGNSSTPRGEGGSCYHFAMSGKSYQVIFQH----FNSLLPKILVNGTVFARMSPGQKS 832

  Fly   760 EIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAA---------RCADFSIARFE 815
            .::...::...|: ...||||||...::.||.||.::.:|...|:         :|....|
Human   833 SLIEEFQKLNYYV-GMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQCVPHLI---- 892

  Fly   816 MLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISF 880
                        ...|.|.:..|..:|.:.:.|.:.......||....::.: |.:|...|.|:
Human   893 ------------REGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGN-YQYLMQDVAIT- 943

  Fly   881 SFTVLAICDKDYSEETLLSHPELYKPLAHNRQAS--------MGVFSLWILNGFVQCFI-IFFFT 936
                |.:|       ..:|....|..||..|.|.        :.:|    ||....|.: |..|.
Human   944 ----LMVC-------LTMSSTHAYPKLAPYRPAGQLLSPPLLLSIF----LNSCFSCIVQISAFL 993

  Fly   937 YA----------------MLNDANVLFN--------------GGQTASFQTFGTMLITIIVIVGN 971
            |.                :.|.:|...|              .|...||:|.....||.|
Human   994 YVKQQPWYCEVYQYSECFLANQSNFSTNVSLERNWTGNATLIPGSILSFETTTLWPITTI----- 1053

  Fly   972 LKLLLVAHYMT---------------YRNFAMILASIAAFMLTTY-LYN----LYTSGELYDVYN 1016
                   :|:|               |.|:......:||..||.: |::    :|...||.....
Human  1054 -------NYITVAFIFSKGKPFRKPIYTNYIFSFLLLAALGLTIFILFSDFQVIYRGMELIPTIT 1111

  Fly  1017 QFLSSLPIWLFTIICSVACLLPDFVIK 1043
            .:...:.:...|..| ||..:.|.:::
Human  1112 SWRVLILVVALTQFC-VAFFVEDSILQ 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	2/11 (18%)
		ATPase-Plipid	28..1051	CDD:273734	231/1132 (20%)
		E1-E2_ATPase	84..>189	CDD:278548	33/130 (25%)
		Cation_ATPase	<489..568	CDD:289987	17/79 (22%)
		HAD_like	<758..807	CDD:304363	15/57 (26%)
		PhoLip_ATPase_C	804..1050	CDD:292829	55/308 (18%)
ATP13A5	NP_940907.2	P5-ATPase	17..137	CDD:289194
		P-ATPase-V	18..1119	CDD:273738	226/1111 (20%)
		Cation_ATPase_N	<170..239	CDD:279080	5/31 (16%)
		E1-E2_ATPase	228..471	CDD:278548	61/334 (18%)
		Cation_ATPase	<595..636	CDD:289987	16/54 (30%)
		COG4087	<822..>871	CDD:226572	17/49 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910