DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and CG4301

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster

Alignment Length:	1279	Identity:	529/1279 - (41%)
Similarity:	735/1279 - (57%)	Gaps:	243/1279 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DPLRIQIGG---IESRQQKPLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETI 71
            |.|:|||||   |:.::.|..||:.:||||..||||.|..|||||...||||::||:|..::..:
  Fly    53 DWLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPV 117

  Fly    72 SPLVSLLPLLFVMIITALKEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRN 136
            ||:.|||||:||:.:||.|:|.||..|.::|.:||::.|||||:|||.||.||.::||:|:||..
  Fly   118 SPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVER 182

  Fly   137 DGDVPCDLVLLQSSSADRKCFVNTANLDGETNLKTICVPTNYLLAGDHELQGKDCIVCEPSSADL 201
            |.|||||||||:|:....|||:.|||||||:||||:.||.:.......|:.....|.||..:.||
  Fly   183 DCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDLPTVDLPEMHKLGIIECESPTTDL 247

  Fly   202 YTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTG 266
            |:|||::||:.|.       |..|||:.:|:||||.|||:||.|:|||:||||.:|||||||.|.
  Fly   248 YSFNGKIELKGGE-------GRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTR 305

  Fly   267 NKSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSF 331
            ||:||||.|||||::.::|.:|.:|.:||.::|:.|..::|.:.|.|..|:..|..|..:|:|||
  Fly   306 NKNASSETYINRFLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSF 370

  Fly   332 LLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTG 396
            |:||||::|||.|:.||:.|:.|..||..||.||:.||||||.||.|||||||||:|||||||||
  Fly   371 LILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTG 435

  Fly   397 TLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDADAAVLFEALAVCHTVEV------ 455
            |||||.|.|..|.:.|..:..:.|.|..|.|....::.|..|:..|.|:||::||||:|
  Fly   436 TLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLE 500

  Fly   456 ---------------------LQEVGDKTLESSESVSEQSHLMSRNIVDR--------------- 484
                                 :..:.|.| |.|.:.|:||.|...:.:|.
  Fly   501 QADAGTAKREPVTAIKSGPPEMYSISDIT-EESHNASQQSELNVGHTIDNSVSAHPNGVNSTIIS 564

  Fly   485 ----------------------------------------------------------------- 484

  Fly   565 SDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFR 629

  Fly   485 ----------------------------------------------------------------- 484

  Fly   630 PISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSR 694

  Fly   485 -----------------------------------YQASSPDEKALLEGCASLGLVYEGQENDVL 514
                                               |||||||||||:|.||:||:||.|.:::.|
  Fly   695 ESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETL 759

  Fly   515 SICRYP----------SAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRC- 568
            .:...|          ...:..|:|||||||:|:|:||||||||.....|:|:|||||.:||.|
  Fly   760 RVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCA 824

  Fly   569 -KASPLVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETV 632
             .::.||.:|||.|:.:|:.||||:|:.||:::::|...|.....:||:.|.||.:|...||..:
  Fly   825 NSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKI 889

  Fly   633 ENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFII 697
            |:.||||||||:|||||:.|.:||.:|||||:|||||||||||||.||.|:|.|||..:|::||:
  Fly   890 ESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIM 954

  Fly   698 NTTEPAELLARLD------MIGDDEPEVLIVDGTTITALLEHTPRQFADLALRCRAVLCCRLSPL 756
            ......|:|..|:      :.|..:...|::||.::...|.....:|.|:|::|.||||||||||
  Fly   955 ECKNREEMLLHLNALDREIIFGIGQECALLIDGKSLGVALAEASSEFRDVAVKCTAVLCCRLSPL 1019

  Fly   757 QKSEIVTLIK-RRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRL 820
            ||||:|:||| ..:.|.||:|||||||||||||||:||||.||||:||||||||:.|:|.||:||
  Fly  1020 QKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRL 1084

  Fly   821 FLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVL 885
            .||||||:|.||:.|||::.||||:..|.|.|:|.:.|:|:::||:|::|.|::::|.|.....:
  Fly  1085 LLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFI 1149

  Fly   886 AICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGG 950
            ||.:|.|:||.|:..|:|||....|:|.....|.:|:|.......|||:|.:......|||.|.|
  Fly  1150 AISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYG 1214

  Fly   951 QTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYT---SGELY 1012
            ||.:|..|||:|:..:|:|.||||.|.:.|:::.....|:.||..|::||.:||:..   ..::|
  Fly  1215 QTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINLDYDTDIY 1279

  Fly  1013 DVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVNDMYRKVPLKS 1056
            ..||..|:|||:||:.|:..||||:||:.|::   :.|.:.:||
  Fly  1280 WAYNNLLASLPVWLWIIVTCVACLVPDYTIRM---LQRALNIKS 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	24/45 (53%)
		ATPase-Plipid	28..1051	CDD:273734	517/1251 (41%)
		E1-E2_ATPase	84..>189	CDD:278548	55/104 (53%)
		Cation_ATPase	<489..568	CDD:289987	44/88 (50%)
		HAD_like	<758..807	CDD:304363	37/49 (76%)
		PhoLip_ATPase_C	804..1050	CDD:292829	106/248 (43%)
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	32/63 (51%)
		ATPase-Plipid	74..1317	CDD:273734	518/1253 (41%)
		E1-E2_ATPase	127..>345	CDD:278548	117/224 (52%)
		Cation_ATPase	<734..823	CDD:289987	44/88 (50%)
		HAD_like	<1036..1066	CDD:304363	25/29 (86%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	107/251 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469561
Domainoid	1	1.000	219	1.000	Domainoid score	I2576
eggNOG	1	0.900	-	-		E2759_KOG0206
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	748	1.000	Inparanoid score	I555
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4775
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
	10	9.910