DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp10b

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_795973.2	Gene:	Atp10b / 319767	MGIID:	2442688	Length:	1474	Species:	Mus musculus

Alignment Length:	1295	Identity:	376/1295 - (29%)
Similarity:	585/1295 - (45%)	Gaps:	307/1295 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN-ETISPLVSLLPLLFVMIITAL 89
            |.|.:.|||||..||||.|.:|||.|....|||.:.|:::..: |.....:::.||..|::|..:
Mouse    67 PGNSICTTKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITIFPLATVLLIIMV 131

  Fly    90 KEGLEDYSRSKSDKLVNTARVTVIRNGKEEII--NSQFIVPGDLVVVRNDGDVPCDLVLLQSSSA 152
            |:|:||:.|...|:.:|:|.:.:....::..:  ..|.:..||.|.::.:..||.|::||.||..
Mouse   132 KDGIEDFKRYCFDREMNSASIQIYERKEQRYMLKRWQDVRVGDFVQMQCNEIVPADILLLFSSDP 196

  Fly   153 DRKCFVNTANLDGETNLKTICVPTNYLLAGDHELQGK-----DCIVCEPSSADLYTFNGRLE--- 209
            ...|.:.|||||||||||...|...:   ...|:|.:     ..||||..:..|..|.|.:|
Mouse   197 SGVCHLETANLDGETNLKQRRVVKGF---SQPEVQFQPEHFHSTIVCEKPNNHLSKFKGYMEHPD 258

  Fly   210 -LRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSE 273
             .|:   |.||          ::|||||..:::||...|..||.|..||..||:.....|.:..|
Mouse   259 QTRT---GFGS----------ESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIE 310

  Fly   274 KYINR---FMVALIVGMIVVVVVLYLI-----ERHKEAKIVPTMPYQGPPT--NFNS-AWQIFED 327
            :.||.   |.:.|:..|.::..|.:.:     :.|.        |:..|..  ||.| |...|..
Mouse   311 RRINTDIFFCIGLLFLMCLIGAVGHSLWNGTFKEHP--------PFDVPDADGNFLSLALGGFYM 367

  Fly   328 FLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFS 392
            ||:.::|...::|||.|::||:.::..:..:||||.|||||||...:..|.|:.|:|||:..:||
Mouse   368 FLTMIILLQVLIPISLYVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFS 432

  Fly   393 DKTGTLTKNLMKFVNCYVPG-------------------------TNYQ---------------- 416
            |||||||:|.|.|..|.:.|                         |.||
Mouse   433 DKTGTLTENKMVFRRCTIVGSEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWAQGSTTMR 497

  Fly   417 -------LQNTH----------------------------------------LVSEGTDEKFELE 434
                   |:..|                                        |:|:..|....||
Mouse   498 SQGGAQPLRRCHSARVPIQSHCRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLE 562

  Fly   435 KLD-----------ADAAVLFEALAVCHTV-------------------------EVLQEVGDK- 462
            ..|           |..|..|.||.:|::|                         |.:|::..:
Mouse   563 TSDTRPAKPSHSTTASIADFFLALTICNSVMVSTTTEPRKRVTTPPANKALGTSLEKIQQLFQRL 627

  Fly   463 ----------------------------TLESSE-------------------SVSEQSHLM--- 477
                                        |::|.|                   |..||..::
Mouse   628 KLLSLSQSFSSTAPSDTDLGESLGPNLPTIDSDEKDDTSVCSGDCSTDGGYRSSTWEQGDILGSE 692

  Fly   478 SRNIVDR---------------YQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQF 527
            |...::.               |:|.||||.||:....:.......:..:.::: |.|....:.|
Mouse   693 SGTSLEEGLEAPTLSQDEPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTV-RLPQGICLTF 756

  Fly   528 KRLHVLEFSSERQRMSVIVRDQ-SDTIWLYSKGAESAIF-----PRCKASPLVE--------QTD 578
            ..|..|.|.|.|:||||:||.. :|.|.:|:|||:|.|.     |.|:::..||        :|.
Mouse   757 DLLFTLGFDSVRKRMSVVVRHPLTDEIIVYTKGADSVIMDLLEDPACESNIDVEKKLKRIRARTQ 821

  Fly   579 AQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATA 643
            ..:..||::||||:.:.::::.:::...:....|:|...|.||.||:....:.:||.|.|||||.
Mouse   822 KHLDLYARDGLRTLCIAKKVVDEEDFQRWASFRREAEASLDNREELLMETAQHLENHLTLLGATG 886

  Fly   644 LEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQH-----------FII 697
            :||.|||.|.:|:.||:.||:::|||||||.|||.||..:|:.:.:....:           .|:
Mouse   887 IEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNIAYSCKLLDQTDTVYSINTENQETCESIL 951

  Fly   698 NTT-----------EPAELLA------RLDMI--GDDEPEV-LIVDGTTITALLE-HTPRQFADL 741
            |.|           :||..|.      ::..:  |...||: |::||.|:.|:.: ....:|.:|
Mouse   952 NCTLEDIKRFHEPQQPARKLCGHRIPPKMPSVNSGAMAPEIGLVIDGKTLNAIFQGKLENKFLEL 1016

  Fly   742 ALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARC 806
            ...||:|||||.:|||||.||.|::.:...:|.:||||||||||||.|.|||||:|:||.||...
Mouse  1017 TQYCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMS 1081

  Fly   807 ADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLW 871
            :||:||||..|::|.|||||:...|||.:|::|.|||:.....:..||.:..:|.:.:.:...:.
Mouse  1082 SDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQMI 1146

  Fly   872 LFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFT 936
            .|::.:.|....:..:.|||.|.||||:.|||||...::...::..|.:.:.:.|.|..|.||..
Mouse  1147 FFNLFFTSLPPIIFGVLDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAFYQSLICFFIP 1211

  Fly   937 YAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFA-----MILASIAAF 996
            |       :.:.|.....| ||||.:.||     :|..:|:...|..:.:.     ::|.|...:
Mouse  1212 Y-------LTYRGSDIDVF-TFGTPINTI-----SLTTILLHQAMEMKTWTVLHGLVLLGSFLMY 1263

  Fly   997 MLTTYLYN-----LYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVNDMYRK 1051
            .:.:.:||     ..:....|.|..:.||....:|..::..|..|||.:.:..:...|.|
Mouse  1264 FVVSLIYNATCVTCNSPTNPYWVMERQLSDPTFYLICLLTPVVALLPRYFLLSLQGTYGK 1323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	20/39 (51%)
		ATPase-Plipid	28..1051	CDD:273734	374/1291 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	35/106 (33%)
		Cation_ATPase	<489..568	CDD:289987	29/84 (35%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	70/255 (27%)
Atp10b	NP_795973.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..43
		P-type_ATPase_APLT_Dnf-like	68..1211	CDD:319770	348/1167 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..707		7/68 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1348..1421
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750