DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp11c

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_006257661.1	Gene:	Atp11c / 317599	RGDID:	1564481	Length:	1130	Species:	Rattus norvegicus

Alignment Length:	1099	Identity:	379/1099 - (34%)
Similarity:	590/1099 - (53%)	Gaps:	123/1099 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISPLVSLLPLLFVMIITALKEG 92
            ||:.::|||.:.|||.|.:|||||...||||||.:|...|:...||:.|.|||.||:.:||:|:|
  Rat    44 NRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVDTPTSPVTSGLPLFFVITVTAIKQG 108

  Fly    93 LEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRKCF 157
            .||:.|.::|..||.:.|.:|.|.|.....|:.|..||:|.|:.|...||||:||.|.:.|..|:
  Rat   109 YEDWLRHRADNEVNKSTVYIIENAKRVRKESEKIKVGDVVEVQADETFPCDLILLSSCTTDGTCY 173

  Fly   158 VNTANLDGETNLKTICVPTNYLLAGDHEL-------QGKDCIVCEPSSADLYTFNGRLELRSGN- 214
            |.||:||||:|.|     |:|.:....||       ..:..|.||....|||.|.||:.:.|.:
  Rat   174 VTTASLDGESNCK-----THYAVRDTIELCTAESIDNLRAAIECEQPQPDLYKFVGRISIYSNSI 233

  Fly   215 DGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRF 279
            :....|.|.      :||||:|..:|:|:::.|.|:||||.||:.||.:....|.::.||.||.|
  Rat   234 EAVARSLGP------ENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAF 292

  Fly   280 MVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFN-SAW---------------QIFEDF 328
            :            ::||.....:|.:..|:.|....|.:| ..|               ::|.||
  Rat   293 L------------IVYLFILLTKAAVCTTLKYVWQSTPYNDEPWYNQKTQKERETFKVLKMFTDF 345

  Fly   329 LSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSD 393
            |||::|||:::|:|.|:.:|:.:..|..|:..|...:|||.::...||.|:||||||||:.:|:|
  Rat   346 LSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTD 410

  Fly   394 KTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEKFE-----------LEKLDADAAVLF-EA 446
            ||||||:|.|:|:.|.:.|..|         :||.::.:           .:|.|.:...|| .|
  Rat   411 KTGTLTENSMEFIECCIDGHKY---------KGTTQEVDGLSQIDGPLAYFDKADKNREELFLRA 466

  Fly   447 LAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQEN 511
            |.:|||||:      ||.::.:...|.:..       .|.:|||||.||::|....|..:.|..|
  Rat   467 LCLCHTVEI------KTNDAVDGPIEGAQF-------TYISSSPDEIALVKGAQKFGFTFLGNWN 518

  Fly   512 DVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKASPLVEQ 576
            ..:.: .....|..:::.||.|.|.|.|:|||||||.|...|.|:.|||:|:||||.. |..::.
  Rat   519 GHIRV-ENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQGGDILLFCKGADSSIFPRVH-SHEIDL 581

  Fly   577 TDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGA 641
            |...:.:.|.:|.||:.|..:.:..|:.........:|...|.:|.|.:...::.:|..::|:||
  Rat   582 TKVHVERNAMDGYRTLCVAFKEIPPDDFERINVQLIEAKMALQDREEKLEKIFDVIETNMNLIGA 646

  Fly   642 TALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSK-QHFIINTTEPAE- 704
            ||:||.||:...||:|||.|||||:|||||||:|||.:...|||.....:: ......|.|.:|
  Rat   647 TAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESER 711

  Fly   705 --------LLARLDMIGDDEPEV---------------LIVDGTTITALLEHT--------PRQF 738
                    |:.....:..:.|:.               ||:||:|::.:|..:        ...|
  Rat   712 KEDRLHELLIEYRKKLLHEFPKSTRSLKKAWTEHQEYGLIIDGSTLSLILNSSQDCSSNNYKSIF 776

  Fly   739 ADLALRCRAVLCCRLSPLQKSEIVTLIKRRK-KYITAAIGDGANDVSMIQEAHIGIGITGREGKQ 802
            ..:.::|.||||||::||||::||.::|..| ..||.:|||||||||||.|:|:||||.|:||:|
  Rat   777 LQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQ 841

  Fly   803 AARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNS 867
            |||.:|:|:.:|:.|::|.|.|||....|:|.||.::.|||:.......|||.:..:|...:|::
  Rat   842 AARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDA 906

  Fly   868 IYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFII 932
            .||.:::|.:.|......::.::..:.:.|.:.|.||..:..|....:|.|..|......:..:.
  Rat   907 AYLTMYNICFTSLPILAYSLLEQHINIDALTADPRLYMKITGNAMLQLGPFLYWTFLAAFEGTVF 971

  Fly   933 FFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFM 997
            ||.||.:....::..||....:: ||||::.|::|....|||.|...:.|:.|..:|..|:|.::
  Rat   972 FFGTYFLFQTTSLEDNGKIYGNW-TFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFYV 1035

  Fly   998 LTTY-----LYNLYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVNDMYRK 1051
            ..::     ::.......:|.|:.|.|||:..||..|:.....|.|:.::.||.::.|:
  Rat  1036 FFSFFWGGIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILLIVVKNVRRR 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	21/37 (57%)
		ATPase-Plipid	28..1051	CDD:273734	378/1097 (34%)
		E1-E2_ATPase	84..>189	CDD:278548	43/111 (39%)
		Cation_ATPase	<489..568	CDD:289987	34/78 (44%)
		HAD_like	<758..807	CDD:304363	31/49 (63%)
		PhoLip_ATPase_C	804..1050	CDD:292829	69/250 (28%)
Atp11c	XP_006257661.1	PhoLip_ATPase_N	38..91	CDD:292826	24/46 (52%)
		ATPase-Plipid	41..1089	CDD:273734	377/1092 (35%)
		E1-E2_ATPase	98..>183	CDD:278548	38/84 (45%)
		Cation_ATPase	469..573	CDD:289987	43/117 (37%)
		HAD_like	<812..841	CDD:304363	21/28 (75%)
		PhoLip_ATPase_C	863..1090	CDD:292829	61/227 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338592
Domainoid	1	1.000	169	1.000	Domainoid score	I3703
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	743	1.000	Inparanoid score	I560
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	1	1.000	-	-		FOG0004283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770