DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp10b

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_017453108.1	Gene:	Atp10b / 303056	RGDID:	1565126	Length:	1472	Species:	Rattus norvegicus

Alignment Length:	1296	Identity:	374/1296 - (28%)
Similarity:	577/1296 - (44%)	Gaps:	309/1296 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN-ETISPLVSLLPLLFVMIITAL 89
            |.|.:.|||||..||||.|.:|||.|....|||.:.|:::..: |.....:::|||..|:::..:
  Rat    67 PGNSICTTKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLLVIMV 131

  Fly    90 KEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINS--QFIVPGDLVVVRNDGDVPCDLVLLQSSSA 152
            |:|.||:.|...|:.:|:|.:.:....::..:..  |.:..||.|.:|.:..||.|::||.||..
  Rat   132 KDGTEDFKRYCFDREMNSASIQIYERKEQSYMQKRWQDVRVGDFVQMRCNEIVPADILLLFSSDP 196

  Fly   153 DRKCFVNTANLDGETNLKTICVPTNYLLAGDHELQGK-----DCIVCEPSSADLYTFNGRL---- 208
            ...|.:.|||||||||||...|...:   ...|:|.:     ..||||..:..|..|.|.:
  Rat   197 SGVCHLETANLDGETNLKQRRVVKGF---SQQEVQFQPEHFHSTIVCEKPNNHLSKFKGYMEHPD 258

  Fly   209 ELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSE 273
            |.|:   |.||          ::|||||..:::||...|..||.|..||..||:.....|.:..|
  Rat   259 ETRT---GFGS----------ESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIE 310

  Fly   274 KYINR---FMVALIVGMIVVVVVLYLI-----ERHKEAKIVPTMPYQGPPT--NFNS-AWQIFED 327
            :.||.   |.:.|:..|.::..|.:.:     :.|.        |:..|..  ||.| |...|..
  Rat   311 RRINTDIFFCIGLLFLMCLIGAVGHSLWNGTFKEHP--------PFDVPDADGNFLSPALGGFYM 367

  Fly   328 FLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFS 392
            ||:.::|...::|||.|::||:.::..:..:||||.|||||||...:..|.|:.|:|||:..:||
  Rat   368 FLTMIILLQVLIPISLYVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFS 432

  Fly   393 DKTGTLTKNLMKFVNCYVPG-------------------------TNYQ---------------- 416
            |||||||:|.|.|..|.:.|                         |.||
  Rat   433 DKTGTLTENKMVFRRCTIVGNEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWTQGPATIR 497

  Fly   417 -------LQNTH----------------------------------------LVSEGTDEKFELE 434
                   |:..|                                        |:|:..|....||
  Rat   498 SQGGAQPLRRCHSARVPIQSHSRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLE 562

  Fly   435 KLD-----------ADAAVLFEALAVCHTVEV----------------------LQEV------- 459
            .||           |..|..|.||.:|::|.|                      |:::
  Rat   563 TLDTRPAKPSHSTTASIADFFLALTICNSVMVSTTTEPRKRVTTPPANKALGTSLEKIQHLFQRL 627

  Fly   460 ------------------------------------------GD---------KTLESSESVSEQ 473
                                                      ||         .|.|..:::..:
  Rat   628 KLLSLSQSFSSTAPSDTDLGESLGPNVPTIDADEKDDASVCSGDCSTDGGYRSSTWEQGDNLGSE 692

  Fly   474 SHLMSRNIVDR-----------YQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQF 527
            |.......::.           |:|.||||.||:....:.......:..:.::: |.|....:.|
  Rat   693 SGTSLEEGLEAPALSLDGPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTV-RLPQGICLTF 756

  Fly   528 KRLHVLEFSSERQRMSVIVRDQ-SDTIWLYSKGAESAIF-----PRC--------KASPLVEQTD 578
            ..|..|.|.|.|:||||:||.. :..|.:|:|||:|.|.     |.|        |...:..:|.
  Rat   757 DLLFTLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLEDPACGNDIDVEKKLKRIRARTQ 821

  Fly   579 AQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATA 643
            ..:..||::||||:.:.::::.:::...:....|:|...|.||.||:....:.:||.|.|||||.
  Rat   822 KHLDLYARDGLRTLCIAKKVVNEEDFQRWASFRREAEASLDNREELLMETAQHLENRLTLLGATG 886

  Fly   644 LEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINT--------- 699
            :||.|||.|.:|:.||:.||:::|||||||.|||.|:..:|:.:.:.... :.|||
  Rat   887 IEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNVAHSCKLLDQADTV-YSINTENQETCESI 950

  Fly   700 --------------TEPAELLARLDM--------IGDDEPEV-LIVDGTTITALLE-HTPRQFAD 740
                          .:||..|....:        :|...||: |::||.|:.|:.: ....:|.:
  Rat   951 LNCALEDVKRFHEPQQPARKLCGYCIPSKKPSVNLGAMAPEIGLVIDGKTLNAIFQGKLENKFLE 1015

  Fly   741 LALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAAR 805
            |...||:|||||.:|||||.||.|::.:...:|.:||||||||||||.|.|||||:|:||.||..
  Rat  1016 LTQYCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVM 1080

  Fly   806 CADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYL 870
            .:||:||||..|::|.|||||:...|||.:|::|.|||:.....:..||.:..:|.:.:.:...:
  Rat  1081 SSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQM 1145

  Fly   871 WLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFF 935
            ..|::.:.|....|..|.|||.|.||||:.|||||...::...::..|.:.:.:.|.|..|.||.
  Rat  1146 IFFNLFFTSLPPIVFGILDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAFYQSLICFFI 1210

  Fly   936 TYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFA-----MILASIAA 995
            .|       :.:.|.....| ||||.:.||     :|..:|:...|..:.:.     ::|.|...
  Rat  1211 PY-------LTYRGSDIDVF-TFGTPINTI-----SLTTILLHQAMEMKTWTVLHGLVLLGSFLM 1262

  Fly   996 FMLTTYLYN-----LYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVNDMYRK 1051
            :.:.:.:||     ..:....|.:..:.||....:|..::..|..|||.:.:..:...|.|
  Rat  1263 YFVVSLIYNATCVTCNSPTNPYWLMERQLSDPMFYLTCLLTPVVALLPRYFLLSLQGTYGK 1323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	20/39 (51%)
		ATPase-Plipid	28..1051	CDD:273734	372/1292 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	35/106 (33%)
		Cation_ATPase	<489..568	CDD:289987	28/84 (33%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	71/255 (28%)
Atp10b	XP_017453108.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338606
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850