DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp9b

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_017456363.1	Gene:	Atp9b / 291411	RGDID:	1563006	Length:	1158	Species:	Rattus norvegicus

Alignment Length:	1136	Identity:	338/1136 - (29%)
Similarity:	544/1136 - (47%)	Gaps:	172/1136 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KKKSADPLRIQIGGIESRQQK-PLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN 68
            :||......:.:|..|..::| |.|.:...||..|||:|...||||:..:..|||:::...|...
  Rat   109 RKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVVSCSQFVPA 173

  Fly    69 ETISPLVSL-LPLLFVMIITALKEGLEDYSRSKSDKLVNT---ARVTVIRNGKEEIINSQFIVPG 129
            ..|..|.:. .||.|||.:|..:|.::::.|.:.||.:|:   :::||  .||.::.:|...| |
  Rat   174 LKIGYLYTYWAPLGFVMAVTIAREAIDEFRRFQRDKEMNSQLYSKLTV--RGKVQVKSSDIQV-G 235

  Fly   130 DLVVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGETN--LKTICVPTNYLLAGDHELQGKDCI 192
            ||::|..:..:|.|:|.|::|.....||:.|..|||||:  ||.....|..|.|..........:
  Rat   236 DLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKVAVSCTQRLPALGDLFSISAYV 300

  Fly   193 VCEPSSADLYTFNGRLELRSGNDGAGSSAGDALP-----LTIDNLLLRGVRVKSTERVVGCAIYT 252
            ..:....|:::|.|..           :..|:.|     |:|:|.|.....|.| ..|:|..|||
  Rat   301 YAQKPQLDIHSFEGTF-----------TRDDSDPPIHESLSIENTLWASTIVAS-GTVIGVVIYT 353

  Fly   253 GMHTKLQLNSRYTGNKSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTN 317
            |..|:..:|:....||....:..:|:...||.:.::|:.||:           |....:.||
  Rat   354 GKETRSVMNTSNPKNKVGLLDLELNQLTKALFLALVVLSVVM-----------VTLQGFAGP--- 404

  Fly   318 FNSAWQIFEDFLSFLLLFNYMVPISAYMNIEVYR-IFGMHFMHNDLHLYDEETDQPCRVNASNLN 381
                |  :.:...|||||:|::|||..:|:::.: .:|...|       .:|......|..|.:.
  Rat   405 ----W--YRNLFRFLLLFSYIIPISLRVNLDMGKAAYGWMIM-------KDENIPGTVVRTSTIP 456

  Fly   382 EELGQVNILFSDKT-----------GTLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEKFELE- 434
            ||||::..|.:|||           .|||:|.|.|...:: ||         ||.|||...|::
  Rat   457 EELGRLVYLLTDKTVTKAKALYSPARTLTQNEMVFKRLHL-GT---------VSYGTDTMDEIQS 511

  Fly   435 ---------------------------------KLDADAAV--LFEALAVCHTVEVLQE-----V 459
                                             |....:.:  ..:|:|:||.|..:.|     .
  Rat   512 HVLNSYLQVHSQTSGHNPSSAPLRRSQSSTPKVKKSVSSRIHEAVKAIALCHNVTPVYEARTGIT 576

  Fly   460 GD-KTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSI-CRYPSA 522
            |: :..|:.:..|:::.        .||||||||.||:....|:||....:  |:.|: .:.||.
  Rat   577 GETEFAEADQDFSDENR--------TYQASSPDEVALVRWTESVGLTLVSR--DLASMQLKTPSG 631

  Fly   523 EKVQFKRLHVLEFSSERQRMSVIVRDQSDT-IWLYSKGAESAIFPRCKASPLVEQTD---AQITK 583
            :.:.:..|.:..|:||.:||.:||||::.. |..|.|||:.|:      |.:|:..|   .:...
  Rat   632 QVLTYCILQMFPFTSESKRMGIIVRDEATAEITFYMKGADVAM------STIVQYNDWLEEECGN 690

  Fly   584 YAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDAL 648
            .|:.||||:.|.:|.||:::...||..|.:|...:.:|...:|:..|::|.|::||..|.:||.|
  Rat   691 MAREGLRTLVVAKRTLTEEQYQDFESRYSQAKLSIHDRTLKVAAVVESLEREMELLCLTGVEDQL 755

  Fly   649 QEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDMIG 713
            |..|..|||.|:.||:|||:|||||:|||..|..:...:.|....|.....|...|....|:...
  Rat   756 QADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRPVTNRGEAHLELNAFR 820

  Fly   714 DDEPEVLIVDGTTITALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGD 778
            ......|::.|.::...|.:...:..:||.:|.||:|||.||.||:.||||:::..:..|.||||
  Rat   821 RKHDCALVISGDSLEVCLRYYEHELVELACQCPAVVCCRCSPTQKAHIVTLLRQHTRKRTCAIGD 885

  Fly   779 GANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKN 843
            |.|||||||.|..||||.|:|||||:..|||||.:|..:.||.:|||..:.:|.|.|..|..::.
  Rat   886 GGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRG 950

  Fly   844 IIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLA 908
            :||:...|::.....:::..:|....:..:..:|..|....| :.|:|...|..:.:|||||.|.
  Rat   951 LIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSL-VLDQDVKPEMAILYPELYKDLT 1014

  Fly   909 HNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLK 973
            ..|..|...|.:|:|....|..|:.:       .|.:||.    |.|.....:..|.:::.   :
  Rat  1015 KGRSLSFKTFLIWVLISIYQGGILMY-------GALLLFE----AEFVHVVAISFTALILT---E 1065

  Fly   974 LLLVAHYMTYRNFAMILA---SIAAFMLTTYLYNLY------TSGELYDVYNQFLSSLP-IWLFT 1028
            ||:||..:...::.|::|   |:..::.:....|.|      :.|...||  .|::::. :|..:
  Rat  1066 LLMVALTIRTWHWLMVVAEFLSLGCYVASLAFLNEYFGIGRVSFGAFLDV--AFITTVTFLWKVS 1128

  Fly  1029 IICSVACLLPDFVIKVVNDMYRKV--PLKSK 1057
            .|..|:| ||.:|:|.:.   ||:  |..||
  Rat  1129 AITVVSC-LPLYVLKYLK---RKLSPPSYSK 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	17/46 (37%)
		ATPase-Plipid	28..1051	CDD:273734	327/1102 (30%)
		E1-E2_ATPase	84..>189	CDD:278548	35/109 (32%)
		Cation_ATPase	<489..568	CDD:289987	29/80 (36%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	65/255 (25%)
Atp9b	XP_017456363.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920