DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and SPAC24B11.12c

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_592849.1	Gene:	SPAC24B11.12c / 2541560	PomBaseID:	SPAC24B11.12c	Length:	1402	Species:	Schizosaccharomyces pombe

Alignment Length:	1257	Identity:	353/1257 - (28%)
Similarity:	585/1257 - (46%)	Gaps:	264/1257 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ESRQQKPLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITI---VSFFVNETISPLVSLLPLL 81
            |:::..|.|::.|.|||...|:|.|.:.||:.....:||.:.|   :|.| .|.::|.::.:||:
pombe    80 EAKRWFPRNKIRTAKYTPIDFIPKNIFLQFQNVANLFFLFLVILQSISIF-GEQVNPGLAAVPLI 143

  Fly    82 FVMIITALKEGLEDYSRSKSDKLVN---TARVTVIRN---------------------------- 115
            .|:.|||:|:.:||:.|:..|..:|   |.|::..:|
pombe   144 VVVGITAVKDAIEDFRRTMLDIHLNNTPTLRLSHYQNPNIRTEYISYFRRFKKRISALFRVFLAK 208

  Fly   116 -------------------------------------GKEEIINSQFIVP--------------- 128
                                                 .|....:|:..||
pombe   209 QEEKKRAKRLNDAVPLEDMAGSESRPSYDSIFRESFEAKRSFEDSKGKVPLSALDGTATILQSRP 273

  Fly   129 --------------------------GDLVVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGET 167
                                      ||.|.|.::.::|.|:|::.||..:..|::.|.||||||
pombe   274 MDIIDYEAEATGECHFKKTYWKDVRVGDFVKVMDNDEIPADIVIINSSDPEGICYIETKNLDGET 338

  Fly   168 NLKTICVPTNYLLAGDHELQGKDCIVC------EPSSADLYTFNGRLELRSGNDGAGSSAGDAL- 225
            |||.    .:.|..|.:.:....|..|      ||..|:||.:||..:....::..||.....:
pombe   339 NLKM----RHALTCGKNVVDEASCERCRFWIESEPPHANLYEYNGACKSFVHSEAGGSDTSQTVS 399

  Fly   226 -PLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLN--------SRYTGNKSASSEKYINRFMV 281
             |:::|::||||..:::|:.|:|..::||..||:.||        ||.|.|  .:...|:| |::
pombe   400 EPISLDSMLLRGCVLRNTKWVIGVVVFTGDDTKIMLNSGAPPLKRSRITRN--LNWNVYLN-FII 461

  Fly   282 ALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMVPISAYMN 346
            ...:..:..||.......|..:...    ::......:.|......|.:.::||..:||||.|::
pombe   462 LFSMCFVCAVVEGIAWRGHSRSSYY----FEFGSIGGSPAKDGVVTFFTGVILFQNLVPISLYIS 522

  Fly   347 IEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVNCYVP 411
            ||:.:.....|::.|..:|.::....|...:.|::::||||..:|||||||||:|:|:|..|.:.
pombe   523 IEIVKTIQAIFIYFDKDMYYKKLKYACTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTIN 587

  Fly   412 GTNYQLQNTHLVS-----EGTD-EKFELEK---LDADAAVL------------------------ 443
            |..|....|..::     ||.| |:..|:|   ::.|...:
pombe   588 GVAYGEAFTEAMAGMAKREGKDTEELTLQKQSFIERDRMQMISQMRNMHDNKYLVDDNLTFISSQ 652

  Fly   444 --------------------FEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQAS 488
                                |.|||:||:| |...|||:.:                    |:|.
pombe   653 FVHDLAGKAGEEQSLACYEFFLALALCHSV-VADRVGDRIV--------------------YKAQ 696

  Fly   489 SPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTI 553
            ||||.||:.....:|.|:..|..|:: :.| ...|..:||.:..:||||.|:||||||:...:..
pombe   697 SPDEAALVGTARDVGFVFLDQRRDIM-VTR-ALGETQRFKLMDTIEFSSARKRMSVIVKGPDNRY 759

  Fly   554 WLYSKGAESAIFPRCKASPLVE---QTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKAN 615
            .|..|||:|.||.|.:.:..||   .|...:..:|..||||:.:.:|.||::|.:.::|.|..|.
pombe   760 VLICKGADSIIFERLEPNEQVELRKTTSEHLRIFALEGLRTLCIAKRELTEEEYYEWKEKYDIAA 824

  Fly   616 TQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNI 680
            :.:.||.|.|....:.:|:.|.|||.||:||.|||.|.:::..|..||:|:|||||||:|||.||
pombe   825 SAIENREEQIEEVADLIESHLTLLGGTAIEDRLQEGVPDSIALLAQAGIKLWVLTGDKMETAINI 889

  Fly   681 GLACRHIPRGSKQHFI-----INTTEPAELLA--------------RLDMIGDDE-----PEVLI 721
            |.:|..:..|......     ::|.|...:||              .|:....|.     ...|:
pombe   890 GFSCNLLDAGMDMIKFDVDQEVSTPELEVILADYLYRYFGLSGSVEELEAAKKDHDTPSGSHALV 954

  Fly   722 VDGTTITALLEHTPR-QFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSM 785
            :||:.:..:|:...| :|..|..||:||||||:||.||:::|.|::...:.:|.|||||||||:|
pombe   955 IDGSVLKRVLDGPMRTKFLLLCKRCKAVLCCRVSPAQKADVVQLVRESLEVMTLAIGDGANDVAM 1019

  Fly   786 IQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCM 850
            ||:|.||:||.|.||:.||..||::|.:|..|.:|.||||.::..|:|.:|..:.||:::.|..:
pombe  1020 IQKADIGVGIVGEEGRAAAMSADYAIGQFRFLSKLVLVHGRWDYNRVAEMVNNFFYKSVVWTFTL 1084

  Fly   851 ALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASM 915
            ..||:|:.:.|..:::..|:.||::::.|....|:.:.|:|.:.:..|..|:|||.......::.
pombe  1085 FWYQIYNNFDANYLFDYTYVMLFNLIFSSLPVIVMGVYDQDVNADLSLRIPQLYKRGILQLNSAR 1149

  Fly   916 GVFSLWILNGFVQCFIIFFFTYAMLNDANVLF-NGGQTASFQTFGTMLITIIVIVGNLKLLLVAH 979
            .:|..::|:||.|..|.|||::.::|:..... ||..|.:.|..|..:....::|.:..::|...
pombe  1150 KIFIGYMLDGFYQSVICFFFSFLVINNVTTAAQNGRDTMAVQDLGVYVAAPTIMVVDTYVILNQS 1214

  Fly   980 YMTYRNFAMILASIAAFMLTTYLY--NLYTSGELYDVYNQFLSSLPIWLFTIICS--VACLLPDF 1040
            .....:..:...|...|...|.:|  :|||. |.|...::...:...|  .::|.  |:||.|.|
pombe  1215 NWDVFSIGLWALSCLTFWFWTGVYSQSLYTY-EFYKSASRIFRTPNFW--AVLCGTIVSCLFPKF 1276

  Fly  1041 V------------IKVVNDMYR 1050
            :            :.::.:.||
pombe  1277 LFMTTQKLFWPYDVDIIRESYR 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	16/48 (33%)
		ATPase-Plipid	28..1051	CDD:273734	351/1249 (28%)
		E1-E2_ATPase	84..>189	CDD:278548	38/213 (18%)
		Cation_ATPase	<489..568	CDD:289987	32/78 (41%)
		HAD_like	<758..807	CDD:304363	26/48 (54%)
		PhoLip_ATPase_C	804..1050	CDD:292829	66/262 (25%)
SPAC24B11.12c	NP_592849.1	ATPase-Plipid	85..1295	CDD:273734	350/1247 (28%)
		PhoLip_ATPase_N	<85..129	CDD:292826	15/43 (35%)
		Cation_ATPase	678..773	CDD:289987	41/117 (35%)
		COG4087	<989..1045	CDD:226572	30/55 (55%)
		PhoLip_ATPase_C	1038..1287	CDD:292829	66/251 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710