DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and ATP11A

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_005268356.1	Gene:	ATP11A / 23250	HGNCID:	13552	Length:	1192	Species:	Homo sapiens

Alignment Length:	1124	Identity:	408/1124 - (36%)
Similarity:	619/1124 - (55%)	Gaps:	123/1124 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ADKKKSADPLRIQIG------GIES--RQQKPLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLI 59
            |.::...|...|.:|      |.|:  .|:.|.||:.::|||::.|:|.|.:|||||...|||||
Human    15 AGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI 79

  Fly    60 ITIVSFFVNETISPLVSLLPLLFVMIITALKEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQ 124
            |.:|...::...||:.|.|||.||:.:||:|:|.||:.|.|:|..:|...|..|::||.....|:
Human    80 IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSR 144

  Fly   125 FIVPGDLVVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGETNLKTICVPTNYLL---AGDH-- 184
            .:..||:|:|:.|...||||:.|.|:..|..|.|.||:||||::.|     |:|.:   .|.|
Human   145 KLRVGDIVMVKEDETFPCDLIFLSSNRGDGTCHVTTASLDGESSHK-----THYAVQDTKGFHTE 204

  Fly   185 -ELQGKDC-IVCEPSSADLYTFNGRLELRSG-NDGAGSSAGDALPLTIDNLLLRGVRVKSTERVV 246
             ::.|... |.||....|||.|.||:.:.|. ||..      ..||..:||||||..:|:||::.
Human   205 EDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPV------VRPLGSENLLLRGATLKNTEKIF 263

  Fly   247 GCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMVA----LIVGMIVVVVVLYLIERHKEAKIVP 307
            |.||||||.||:.||.:....|.::.||.:|.|::.    ||...::..|:.|:.:
Human   264 GVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQ--------- 319

  Fly   308 TMPYQGPP---------TNFNSAWQIFEDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLH 363
            :.|::..|         ...|...:.|.|||:|::||||::|:|.|:.:|:.:..|.:|:..|..
Human   320 SEPFRDEPWYNQKTESERQRNLFLKAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDED 384

  Fly   364 LYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEG-- 426
            ::||||.:...||.|:||||||||..:|:|||||||:|.|:|..|.:.|..|.   .|::..|
Human   385 MFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYV---PHVICNGQV 446

  Fly   427 TDEKFELEKLDADAAV--------LFEALAVCHTVEVLQEVGDKTLESSESVS--EQSHLMSRNI 481
            ..|...::.:|:..:|        .|.||.:||||:|         :..:||.  .:|....::.
Human   447 LPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQV---------KDDDSVDGPRKSPDGGKSC 502

  Fly   482 VDRYQASSPDEKALLEGCASLGLVYEGQENDVLSIC-RYPSAEKVQFKRLHVLEFSSERQRMSVI 545
            |  |.:|||||.||:||...||..|...:::.:.|. |....|:  |:.|.:|.|.|.|:|||||
Human   503 V--YISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENHIER--FELLEILSFDSVRRRMSVI 563

  Fly   546 VRDQSDTIWLYSKGAESAIFPRCKASPLVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEEL 610
            |:..:..|:|:.|||:|:||||. ....|:|..|::.:.|..||||:.|..:.|..:|.....:|
Human   564 VKSATGEIYLFCKGADSSIFPRV-IEGKVDQIRARVERNAVEGLRTLCVAYKRLIQEEYEGICKL 627

  Fly   611 YRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVE 675
            .:.|...|.:|.:.:|..||.:|.:|.||||||:||.|||...:|:||||.||:|:|||||||:|
Human   628 LQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKME 692

  Fly   676 TAYNIGLACRHIPRGSKQHFIINTTEPAE--------------------LLARLDMIG---DDEP 717
            ||.....||:...|.::  .:..||:..|                    .|.|.::.|   |.:.
Human   693 TAAATCYACKLFRRNTQ--LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQD 755

  Fly   718 EVLIVDGTTITALLEHTPRQ----------FADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKY- 771
            ..||:||..::.:::  ||:          |.::...|.||||||::||||::||.|||..|::
Human   756 YGLIIDGAALSLIMK--PREDGSSGNYRELFLEICRSCSAVLCCRMAPLQKAQIVKLIKFSKEHP 818

  Fly   772 ITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLV 836
            ||.||||||||||||.|||:|||:.|:||:||||.:|::|.:|:.|:::.|||||:...|::.||
Human   819 ITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELV 883

  Fly   837 LFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHP 901
            .::.|||:.......|||.:..:|...:|::.||.|::|.:.|....:.::.::....:.|...|
Human   884 QYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDP 948

  Fly   902 ELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITII 966
            .||:.:|.|......||..|.|.|.....:.||..|.:..:..|..| ||.....||||::.|::
Human   949 TLYRDVAKNALLRWRVFIYWTLLGLFDALVFFFGAYFVFENTTVTSN-GQIFGNWTFGTLVFTVM 1012

  Fly   967 VIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYN-----LYTSGELYDVYNQFLSSLPIWL 1026
            |....|||.|..||.|:.|..:|..|:..:::.:.|:.     ......:|.|:.|.|||.|.||
Human  1013 VFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQRMYYVFIQMLSSGPAWL 1077

  Fly  1027 FTIICSVACLLPDFVIKVV 1045
            ..::.....||||.:.||:
Human  1078 AIVLLVTISLLPDVLKKVL 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	23/47 (49%)
		ATPase-Plipid	28..1051	CDD:273734	400/1091 (37%)
		E1-E2_ATPase	84..>189	CDD:278548	40/110 (36%)
		Cation_ATPase	<489..568	CDD:289987	35/79 (44%)
		HAD_like	<758..807	CDD:304363	34/49 (69%)
		PhoLip_ATPase_C	804..1050	CDD:292829	77/247 (31%)
ATP11A	XP_005268356.1	PhoLip_ATPase_N	42..95	CDD:292826	24/52 (46%)
		ATPase-Plipid	45..1110	CDD:273734	401/1094 (37%)
		E1-E2_ATPase	102..>187	CDD:278548	36/84 (43%)
		Cation_ATPase	477..585	CDD:289987	45/120 (38%)
		R3H	639..695	CDD:294210	33/55 (60%)
		HAD_like	<806..849	CDD:304363	29/42 (69%)
		PhoLip_ATPase_C	851..1103	CDD:292829	77/247 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144897
Domainoid	1	1.000	214	1.000	Domainoid score	I2728
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	807	1.000	Inparanoid score	I493
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	1	1.000	-	-		FOG0004283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770