DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp10d

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_700438.3	Gene:	Atp10d / 231287	MGIID:	2450125	Length:	1469	Species:	Mus musculus

Alignment Length:	1337	Identity:	370/1337 - (27%)
Similarity:	583/1337 - (43%)	Gaps:	334/1337 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GADKKKSADPLRIQIGGIESRQQKPL--------------------------NRVTTTKYTWFTF 40
            |.|::.......:..||..||..:|.                          ||:.|||||...|
Mouse    75 GEDERPYNYASLLACGGKSSRTPRPAGKHRVVIPHLQCFKDEYERFSGTYVNNRIRTTKYTLLNF 139

  Fly    41 LPLNFYEQFRRAVYFYFLIITIVSFF-VNETISPLVSLLPLLFVMIITALKEGLEDYSRSKSDKL 104
            :|.|.:|||.||...|||.:.::::. :.|.....:::|||:.|:.|.|:|:|||||.:.|.||.
Mouse   140 VPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQ 204

  Fly   105 VNTARVTVIRNGKEEIINS--QFIVPGDLVVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGET 167
            :|.....|....:::.|:.  :.:..||.:.:..:..:|.|:|||.|:..|..|.:.|:.||||:
Mouse   205 INNLITKVYSRKEKKYIDCCWKNVTVGDFIRLSCNEIIPADMVLLFSTDPDGICHIETSGLDGES 269

  Fly   168 NLKTICVPTNYLLAGDHELQGK---DCIVCEPSSADLYTFNGRLELRSGNDGAGSSAGDALPLTI 229
            |||...|...| ...|.|:..:   ..|.||..:.||..|.|.|| .:..:..|        |:.
Mouse   270 NLKQRQVVRGY-TEQDSEVDPEKFSSRIECESPNNDLSRFRGFLE-HANKERVG--------LSK 324

  Fly   230 DNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMVALIVGMIVVVV-- 292
            :||||||..:::||.|||..:|.|..||..||:.....|.:..|:..|..::..::.:||:.:
Mouse   325 ENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWCVLLLIVMCLTG 389

  Fly   293 -------------VLYLIERHKEAKIV-PTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMVPISA 343
                         :|:......:.::: |.:      |.|...|       :.::|...::|||.
Mouse   390 ALGHGIWLSRYENMLFFNIPEPDGRVISPVL------TGFYVFW-------TMIILLQVLIPISL 441

  Fly   344 YMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVNC 408
            |::||:.::..::|:.:|:..|:|:.|...:..|.|:.|:|||:..||||||||||:|.|.|..|
Mouse   442 YVSIEIVKLGQIYFIQSDVDFYNEKMDSTIQCRALNITEDLGQIQYLFSDKTGTLTENKMVFRRC 506

  Fly   409 YVPGTNY------------------------------------------------------QLQ- 418
            .|.|.:|                                                      ||.
Mouse   507 SVAGFDYCHEENAKRLESYQEAVSEEEECTDTLGGSLSNMARPRAQGCRTVPSGPLGKPSAQLSG 571

  Fly   419 NTHLVSEG-------------------TD--------EKFE------LEKLDADAAV-------- 442
            :|..|..|                   ||        :||.      |..||..|..
Mouse   572 STSAVGNGEGSGEVPHSRQAAFSSPMETDVVPDTRLLDKFSQLTPQLLTGLDGTAQSSPLETLYI 636

  Fly   443 --LFEALAVCHTVEV-----------LQEVGDKTLESSESV-----------SEQSHLMSRN--- 480
              .|.|||:|:||.|           |..:|...::|.|.:           |....|.|..
Mouse   637 MDFFIALAICNTVVVSAPNQPRQKIGLSSLGGMPIKSLEEIKNIFQKLSVRRSSSPSLASGKDSS 701

  Fly   481 ------IVDR------------------------------------------------------- 484
                  .|.|
Mouse   702 SGTPCAFVSRISFFSRPKLSPPMEDESSQMDEIPQASNSACCTETEAQNRAVGLSVSSAEALSGP 766

  Fly   485 --------YQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQR 541
                    |:|.||||.||:....:.....:.:..:.:.: .:.:...:.|:.||:|.|.|.|:|
Mouse   767 PPSASNLCYEAESPDEAALVYAARAYRCTLQSRTPEQVMV-DFAALGSLTFQLLHILPFDSVRKR 830

  Fly   542 MSVIVRDQ-SDTIWLYSKGAESAIFPRCKASP-----------LVEQTDAQITKYAQNGLRTMAV 594
            |||:||.. |..:.:|:|||:|.|......:.           :.|:|...:.:||:.||||:.|
Mouse   831 MSVVVRHPLSKQVVVYTKGADSVIMELLSVAASDGTNPEQQMIIRERTQRHLDEYAKRGLRTLCV 895

  Fly   595 GRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEAL 659
            .:::::|.|...:...:..|.|.:.||.||:......:||:|.|||||.:||.|||.|.|::|||
Mouse   896 AKKVMSDTEYAEWLRNHFLAETSIDNREELLVESAMRLENKLTLLGATGIEDRLQEGVPESIEAL 960

  Fly   660 QAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEP-------AELLARLDMIGDDEP 717
            ..||:|||:|||||.|||.||..||:.:....|. ||:||...       :.:|..|.......|
Mouse   961 HQAGIKIWMLTGDKQETAVNIAYACKLLEPDDKL-FILNTQSQDACGMLMSAILEELQKRAQVSP 1024

  Fly   718 EV--------------------LIVDGTTIT-ALLEHTPRQFADLALRCRAVLCCRLSPLQKSEI 761
            |:                    |::.|.|:. ||.|...|||.:|...|:||:|||.:||||||:
Mouse  1025 ELASSRKNFPQPSDAQGQGRAGLVITGKTLEFALQESLQRQFLELTAWCQAVICCRATPLQKSEV 1089

  Fly   762 VTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGH 826
            |.|::.....:|..||||||||||||.|.||||::|:||.||...:||:|::|..|.:|.|||||
Mouse  1090 VKLVRNHHHVLTLPIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAISQFRHLSKLLLVHGH 1154

  Fly   827 YNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKD 891
            :...||:.::|::.|||:.....:..||.:..:|.|::.:...|..|::::.|....:..:.:||
Mouse  1155 WCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSVPPIIYGVLEKD 1219

  Fly   892 YSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQ---CFIIFFFTYAMLNDANVLFNGGQTA 953
            .|.||||..||||:....:.:.....|.:.:|:.|.|   ||.:.:|||.           |...
Mouse  1220 VSAETLLQLPELYRSGQRSEEYLPLTFWITLLDAFYQSLVCFFVPYFTYQ-----------GSDI 1273

  Fly   954 SFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYTSGEL------- 1011
            ...|||..|.|..:.:..|.|::.:..:|:.:..:.:.||     .:|.:.....|.|
Mouse  1274 DIFTFGNPLNTAALFIILLHLVIESKSLTWIHMLVTVGSI-----LSYFFFALAFGALCVTCNPP 1333

  Fly  1012 ---YDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVV 1045
               |.:..:.:.....:|..::.:...|||.|:.:|:
Mouse  1334 SNPYGIMRKHMLDPVFYLVCVLTTFVALLPRFLYRVL 1370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	21/71 (30%)
		ATPase-Plipid	28..1051	CDD:273734	363/1285 (28%)
		E1-E2_ATPase	84..>189	CDD:278548	36/106 (34%)
		Cation_ATPase	<489..568	CDD:289987	26/79 (33%)
		HAD_like	<758..807	CDD:304363	28/48 (58%)
		PhoLip_ATPase_C	804..1050	CDD:292829	65/255 (25%)
Atp10d	NP_700438.3	ATPase-Plipid	124..1377	CDD:273734	363/1288 (28%)
		PhoLip_ATPase_N	<124..175	CDD:292826	19/50 (38%)
		E1-E2_ATPase	181..406	CDD:278548	71/234 (30%)
		Cation_ATPase	<779..859	CDD:289987	26/80 (33%)
		HAD_like	<1101..1132	CDD:304363	22/30 (73%)
		PhoLip_ATPase_C	1132..1377	CDD:292829	65/255 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840