DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and ATP10B

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001353581.1	Gene:	ATP10B / 23120	HGNCID:	13543	Length:	1461	Species:	Homo sapiens

Alignment Length:	1294	Identity:	374/1294 - (28%)
Similarity:	585/1294 - (45%)	Gaps:	313/1294 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ESRQQKPLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN-ETISPLVSLLPLLFV 83
            |..::.|.||..|||||.|||||.|.:|||.|....|||.:.|:::..: |.....:::|||..|
Human    61 EVSRRYPGNRTCTTKYTLFTFLPRNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIV 125

  Fly    84 MIITALKEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINS--QFIVPGDLVVVRNDGDVPCDLVL 146
            :.:..:|:|:||:.|.:.||.:|.:.:.:....::..:..  :.:..||.:.::.:..||.|::|
Human   126 LFVIMIKDGMEDFKRHRFDKAINCSNIRIYERKEQTYVQKCWKDVRVGDFIQMKCNEIVPADILL 190

  Fly   147 LQSSSADRKCFVNTANLDGETNLKTICVPTNYLLAGDHELQGK-----DCIVCEPSSADLYTFNG 206
            |.||..:..|.:.||:||||||||..||...:   ...|:|.:     :.||||..:..|..|.|
Human   191 LFSSDPNGICHLETASLDGETNLKQRCVVKGF---SQQEVQFEPELFHNTIVCEKPNNHLNKFKG 252

  Fly   207 RLE----LRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGN 267
            .:|    .|:|             ...::|||||..:::||..||..||.|..||..||:.....
Human   253 YMEHPDQTRTG-------------FGCESLLLRGCTIRNTEMAVGIVIYAGHETKAMLNNSGPRY 304

  Fly   268 KSASSEKYIN---RFMVALIVGMIVVVVVLYLI-----ERHKEAKIVPTMPYQGPPTN---FNSA 321
            |.:..|:.:|   .|.:.:::.|.::..|.:.|     |.|.        |:..|..|   ..||
Human   305 KRSKIERRMNIDIFFCIGILILMCLIGAVGHSIWNGTFEEHP--------PFDVPDANGSFLPSA 361

  Fly   322 WQIFEDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQ 386
            ...|..||:.::|...::|||.|::||:.::..:.|:.|||.|||||||...:..|.|:.|:|||
Human   362 LGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFFLSNDLDLYDEETDLSIQCRALNIAEDLGQ 426

  Fly   387 VNILFSDKTGTLTKNLMKFVNCYVPGTNYQLQNT--------HLVSEG----------------- 426
            :..:|||||||||:|.|.|..|.:.|:.|..|..        .|.|:|
Human   427 IQYIFSDKTGTLTENKMVFRRCTIMGSEYSHQENAKRLETPKELDSDGEEWTQYQCLSFSARWAQ 491

  Fly   427 -----------------------------------------------------TDEKFELEKLDA 438
                                                                 |.:|..|.|: .
Human   492 DPATMRSQKGAQPLRRSQSARVPIQGHYRQRSMGHRESSQPPVAFSSSIEKDVTPDKNLLTKV-R 555

  Fly   439 DAAV-----------------------LFEALAVCHTV-------------------------EV 455
            |||:                       .|.||.:|::|                         |.
Human   556 DAALWLETLSDSRPAKASLSTTSSIADFFLALTICNSVMVSTTTEPRQRVTIKPSSKALGTSLEK 620

  Fly   456 LQEV-----------------------------------------------GDKT---------- 463
            :|::                                               ||.|
Human   621 IQQLFQKLKLLSLSQSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRSSMW 685

  Fly   464 -----LESSESVS-EQSHLMSRNIVDR----YQASSPDEKALLEGCASLGLVYEGQENDVLSICR 518
                 |||....| |::.......:.|    |:|.||||.||:....:.......:..:.::: |
Human   686 DQGDILESGSGTSLEEALEAPATDLARPEFCYEAESPDEAALVHAAHAYSFTLVSRTPEQVTV-R 749

  Fly   519 YPSAEKVQFKRLHVLEFSSERQRMSVIVRDQ-SDTIWLYSKGAESAIF-----PRC--------K 569
            .|....:.|..|..|.|.|.|:||||:||.. :..|.:|:|||:|.|.     |.|        |
Human   750 LPQGTCLTFSLLCTLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLEDPACVPDINMEKK 814

  Fly   570 ASPLVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVEN 634
            ...:..:|...:..||::||||:.:.::::::::...:....|:|...|.||:||:....:.:||
Human   815 LRKIRARTQKHLDLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDELLMETAQHLEN 879

  Fly   635 ELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINT 699
            :|.|||||.:||.|||.|.:|:..|:.||:::|||||||.|||.||..:||.:.: :...:.|||
Human   880 QLTLLGATGIEDRLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSCRLLNQ-TDTVYTINT 943

  Fly   700 --TEPAE---------------------------LLARLDMIGDDE--PEV-LIVDGTTITALLE 732
              .|..|                           |.::...|..:.  ||. |::||.|:.|:.:
Human   944 ENQETCESILNCALEELKQFRELQKPDRKLFGFRLPSKTPSITSEAVVPEAGLVIDGKTLNAIFQ 1008

  Fly   733 -HTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGIT 796
             ...::|.:|...||:|||||.:|||||.||.|::.:.:.:|.:||||||||||||.|.|||||:
Human  1009 GKLEKKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLRVMTLSIGDGANDVSMIQAADIGIGIS 1073

  Fly   797 GREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSA 861
            |:||.||...:||:|.||:.|::|.|||||:...|||.:|::|.|||:.....:..||.:..:|:
Human  1074 GQEGMQAVMSSDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKNVCYVNLLFWYQFFCGFSS 1138

  Fly   862 TNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGF 926
            :.:.:...:..|::.:.|....|..:.|||.|.||||:.|||||...::...::..|.:.:::.|
Human  1139 STMIDYWQMIFFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQNSECYNLSTFWISMVDAF 1203

  Fly   927 VQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNF----- 986
            .|..|.||..|       :.:.|.....| ||||.:.||     :|..:|:...|..:.:
Human  1204 YQSLICFFIPY-------LAYKGSDIDVF-TFGTPINTI-----SLTTILLHQAMEMKTWTIFHG 1255

  Fly   987 AMILASIAAFMLTTYLYN-----LYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDF 1040
            .::|.|...:.|.:.|||     ..:....|.|....||:...:|...:..|..|||.:
Human  1256 VVLLGSFLMYFLVSLLYNATCVICNSPTNPYWVMEGQLSNPTFYLVCFLTPVVALLPRY 1314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	23/45 (51%)
		ATPase-Plipid	28..1051	CDD:273734	372/1286 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	32/106 (30%)
		Cation_ATPase	<489..568	CDD:289987	28/84 (33%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	72/247 (29%)
ATP10B	NP_001353581.1	P-type_ATPase_APLT_Dnf-like	68..1213	CDD:319770	345/1171 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..541		0/44 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..687		3/47 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1346..1397
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144908
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750