DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and catp-5

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001309699.1	Gene:	catp-5 / 181067	WormBaseID:	WBGene00019493	Length:	1202	Species:	Caenorhabditis elegans

Alignment Length:	1250	Identity:	237/1250 - (18%)
Similarity:	425/1250 - (34%)	Gaps:	429/1250 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KYTWF-------------TFLPLNFYEQF--------------RRAVY----------------- 54
            ||.|:             :..|.|.|::.              .|.:|
Worm   155 KYIWYEKDQEWLNPADMDSAAPFNIYQKLTLDVIGLKEQDVIASRKIYNMNALALALTPILVILF 219

  Fly    55 ------FYFLIITIVSFFVNETISPLVSLLPLLFVMIITALKEGLEDYSRSKSDKLV-----NTA 108
                  ||......|:.:.::..:...|:     ::|||.....:..|.....:|.:     :|.
Worm   220 KEVLGPFYLFQCFSVALWYSDNYAYYASV-----IVIITVGSAAVAVYQMRAQEKRIRNMVGDTI 279

  Fly   109 RVTVIRNGKEEIINSQFIVPGDLVVV-RNDGDVPCDLVLLQSSSADRKCFVNTANLDGETNLKTI 172
            .|.|.|:|.:..|::..|||.|:::: .|...:|||.:|:..:     ..||.|.|.||:
Worm   280 SVIVRRDGHDITIDASEIVPMDILILPSNTFILPCDCLLMNGT-----VIVNEAMLTGES----- 334

  Fly   173 CVPTNYLLAGDHELQGKDCIVCEP-----SSADLYT-FNGRLELRSGNDGAGSSAGDALPLTIDN 231
             ||..       :...|:...|.|     |..:.:| |:|...|::.|
Worm   335 -VPVT-------KASLKEADECGPEIRLSSEHNRHTLFSGTTVLQTRN----------------- 374

  Fly   232 LLLRGVRVKSTERVVGCAIYTGMHT-KLQLNSRYTGNKSASSEKYINRFMVALIVGMIVVVVVLY 295
              .:|      :.|:...|.||..| |.||.......|....|...:..:..|::|.|.::..:|
Worm   375 --YKG------QPVMARVIRTGFSTLKGQLVRSIMYPKPQEKEALKDVMVFILVLGFIALIGFIY 431

  Fly   296 ----LIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMVP-----------ISAYM 345
                ::.|.:..|.:                     .:..|.:...:||           |:|..
Worm   432 TVIEMVSRGESLKHI---------------------IIRSLDIITIVVPPALPAAMSVGIINANS 475

  Fly   346 NIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVNCYV 410
            .::..:||               ...|..||.      .|.:|:...|||||||::.:.| ||
Worm   476 RLKKKKIF---------------CTSPTTVNV------CGLINVACFDKTGTLTEDGLDF-NC-- 516

  Fly   411 PGTNYQLQNTHLVSEGTDEKFELE--KLDADAAVL--FEALAVCHTVEVLQEVGDKTLES----- 466
              .....:|.....|.|.|..||:  ||.|:.|.|  ..|.|.||::..:    |.||..
Worm   517 --LKAIRKNEDGKPEFTSEFEELDPVKLSAENANLNIVVAAASCHSLTRI----DGTLHGDPLEL 575

  Fly   467 ----------SESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPS 521
                      .|:|:........:.|.......|.|:|          .|..:.|:...|.::|
Worm   576 ILVEKSKWIIEEAVNSDEETQDFDTVQPTVLRPPPEQA----------TYHPENNEYSVIKQHP- 629

  Fly   522 AEKVQFKRLHVLEFSSERQRMSVIVRDQSD----TIWLYSKGAESAIFPRCKASPLVEQTDAQIT 582
                         |:|..||||||:...|:    .:.:::||:...|...|....:.|.....:.
Worm   630 -------------FNSALQRMSVIISTPSEHSAHDMMVFTKGSPEMIASLCIPDTIPEDYMEVVD 681

  Fly   583 KYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDA 647
            :|||.|.|.:||..:.:      |..  :.||          :.:..:.:|:||:.||...:|:.
Worm   682 EYAQRGFRLIAVASKAV------HLN--FAKA----------LKTPRDIMESELEFLGLIVMENR 728

  Fly   648 LQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDMI 712
            |::.....:..|..|.::..::|||.:.||.::...| .|.|.:|:.|:|..::..:     |.:
Worm   729 LKDVTLSVINELSVANIRCVMVTGDNLLTAMSVAREC-GIIRPTKKAFLITHSKTEK-----DPL 787

  Fly   713 G-----------------DDEPEV---------------LIVDGTTITALLEHTPRQFADLALRC 745
            |                 |.:.||               :.:.|.|.:.:....|.....:...|
Worm   788 GRTKLFIKESVSSSENDIDTDSEVRAFDRKAVLRTATYQMAIAGPTYSVITHEYPELVDRITAMC 852

  Fly   746 RAVLCCRLSPLQKSEIVTLIKRRKKYITAAI---GDGANDVSMIQEAHIGIGITGREGKQAA--- 804
            .  :..|::|.||::::..::.    |.|.:   ||||||.:.::.||.||.::..|...||
Worm   853 D--VYARMAPDQKAQLIGALQE----IGAKVSMCGDGANDCAALKAAHAGISLSQAEASIAAPFT 911

  Fly   805 ----------------RCA---DFSIARF-------EMLRRLFLVHGHYNSQRLAFLVLFYCYKN 843
                            |||   .::::::       |.|..:.|.:...|.....||     |.:
Worm   912 SNVPDIRCVPTVIKEGRCALVTSYAVSKYMAAYSLNEFLSVMLLYNDGTNISDGQFL-----YID 971

  Fly   844 IIITGCMALY------------------------------QVY---------------------- 856
            :::...:||:                              |::
Worm   972 LVLITLVALFLGNTEASRKLSGIPPPRRLATSAFYFSVFGQMFFNIITQTTGYLLVRGQSWYVPN 1036

  Fly   857 --DLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFS 919
              :|.:.|.:..:...:....:|:.::|.        ||:    .||  |:         ..||:
Worm  1037 PEELDNTTTMIGTTVFFTSCCMYLGYAFV--------YSK----GHP--YR---------RSVFT 1078

  Fly   920 LWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTF-------GTMLITIIVIVGNLKLLLV 977
            .|:|.|.:       |....:|...:..|.|...:...|       ...::..|.:.|....||.
Worm  1079 NWLLCGII-------FVIGAINMVMIFTNMGFLMNLMGFVYVPSTSMRFILLAISLAGVFLSLLY 1136

  Fly   978 AHYMTYRNFAMILASIAAFMLTTYLYNLYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVI 1042
            .|:...:   ::.....:::....|.|...|...|:.....:.|.|.|.            :..|
Worm  1137 EHFFVEK---VVAIHFESYLRQRRLRNGDPSLSAYEKILAAIGSSPRWF------------EDEI 1186

  Fly  1043 KVVNDMYRKVPLKSK 1057
            .:...:.||..::||
Worm  1187 NLSKSIDRKETIESK 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	11/81 (14%)
		ATPase-Plipid	28..1051	CDD:273734	233/1242 (19%)
		E1-E2_ATPase	84..>189	CDD:278548	28/110 (25%)
		Cation_ATPase	<489..568	CDD:289987	19/82 (23%)
		HAD_like	<758..807	CDD:304363	17/70 (24%)
		PhoLip_ATPase_C	804..1050	CDD:292829	46/335 (14%)
catp-5	NP_001309699.1	P-ATPase-V	52..1125	CDD:273738	220/1157 (19%)
		P5-ATPase	52..154	CDD:289194
		E1-E2_ATPase	247..490	CDD:278548	63/326 (19%)
		Cation_ATPase	<614..667	CDD:289987	16/66 (24%)
		HAD_like	<846..910	CDD:304363	20/69 (29%)
		Cation_ATPase_C	966..1136	CDD:295563	28/204 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910