DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and eat-6

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_506269.1	Gene:	eat-6 / 179796	WormBaseID:	WBGene00001137	Length:	996	Species:	Caenorhabditis elegans

Alignment Length:	1159	Identity:	233/1159 - (20%)
Similarity:	408/1159 - (35%)	Gaps:	376/1159 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 WFTFLPLNFYEQFRRAVYFYFLIITI---VSFFVNETISP--LVSLLPLLFVMIITALKEGLEDY 96
            |..|.. |.:..|...::...::..|   |.:|..|..|.  |...:.|:.|::||.:   .:.|
Worm    67 WIKFCK-NLFGGFAMLLWVGAILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVVITGV---FQYY 127

  Fly    97 SRSKSDKLVNTAR------VTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRK 155
            ..|||.|::::.:      ..|.|:|:::.:.::.:|.||:|.|:....||.||.::.:....
Worm   128 QESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFK-- 190

  Fly   156 CFVNTANLDGETNLKTICVPTNYLLAGDHELQGKDCIVCEPSSADLYTFNGRLELR-----SGND 215
              |:.::|.||:               :.:.:..||           |....||.|     |.|.
Worm   191 --VDNSSLTGES---------------EPQSRSPDC-----------TNENPLETRNIAFFSTNA 227

  Fly   216 GAGSSAGDALPLTIDNL-------LLRGVRVKST----------ERVVGCAIYTGMHTKLQLNSR 263
            ..|::.|..: .|.||.       |..|:....|          ..:.|.|::.|
Worm   228 VEGTAKGIVI-YTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLG---------- 281

  Fly   264 YTGNKSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDF 328
                        |:.|::|.|:|...:..|::||     ..||..:| :|
Worm   282 ------------ISFFIIAFILGYHWLTAVVFLI-----GIIVANVP-EG--------------- 313

  Fly   329 LSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSD 393
                    .:..::..:.:...|:                ..:.|.|......|.||..:.:.||
Worm   314 --------LIATVTVCLTLTAKRM----------------ASKNCLVKNLEAVETLGSTSTICSD 354

  Fly   394 KTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDADAAVLFEALAVCHTVEVLQE 458
            ||||||:|.|...:.:...|.::...|.  ::.:.||    :..|....|....::|:..|
Worm   355 KTGTLTQNRMTVAHMWYDETIHECDTTE--TQTSQEK----RTGASFEALVRIASLCNRAE---- 409

  Fly   459 VGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGC----ASLGLV--YEGQENDVLSIC 517
                                      ::|...|...|...|    :.:.|:  .|..:.:|:::
Worm   410 --------------------------FKAGQQDTPILRRDCTGDASEIALLKFTELTQGNVIAV- 447

  Fly   518 RYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAE-------SAIFPRCKASPLVE 575
                  :.:.|::..:.|:| ..:..|.:.|..|...|..|||.       |.||...|.|.|.:
Worm   448 ------REKNKKIAEIPFNS-TNKYQVSIHDNGDHYLLVMKGAPERILDVCSTIFLNGKESELTD 505

  Fly   576 QTDAQI-TKYAQNGLRTMAVGRR-------MLTDDEL---FHFEELYRKANTQLSNRNELIASCY 629
            :..... |.|.:.|    .:|.|       :|..|:.   |.|:  ..:.|..|.|
Worm   506 KLREDFNTAYLELG----GMGERVLGFCDFVLPADKFPKGFKFD--VEEVNFPLKN--------- 555

  Fly   630 ETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQH 694
                  |..:|..::.|..:..|.:.:...::||:|:.::|||...||..|..:...|..|
Worm   556 ------LRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDG---- 610

  Fly   695 FIINTTEPAELLA-----RLDMIGDDEPEVLIVDGTTITALLEHTPRQFADLALRCRAVLCCRLS 754
                 ||..|.:|     .::.:...|.:..::.|:.:..:.|.   |.|::......::..|.|
Worm   611 -----TETVEDIAIRRGIPVEEVNPREAKAAVIHGSDLREMSED---QLAEIIKYHSEIVFARTS 667

  Fly   755 PLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGI--GITGRE-GKQAARCADFSIARFEM 816
            |.||..||...:::.: |.|..|||.||...:::|.||:  ||.|.: .||||
Worm   668 PQQKLMIVEGFQKQGQ-IVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA------------ 719

  Fly   817 LRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFD------- 874
              .:.|:..::.|               |:.|......::|     |:..||...|..
Worm   720 --DMILLDDNFAS---------------IVVGVEEGRLIFD-----NLKKSIAYTLTSNIPEISP 762

  Fly   875 -IVYISFSF-----TVLAIC-----------DKDYSE--------------------ETLLSHPE 902
             :.||.|..     ||..:|           ...|.|                    |.|:|
Worm   763 FLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPIRDKLVNERLIS--- 824

  Fly   903 LYKPLAHNR----QASMGVFS-LWIL--NGFVQCFIIFF-------------------FTYAMLN 941
                ||:.:    |||.|.|: .||:  |||:...:...                   :|||
Worm   825 ----LAYGQIGMIQASAGFFTYFWIMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWTYA--- 882

  Fly   942 DANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMT--YRNFAMILASIAAFMLTTYLYN 1004
            :..:|....|||.|.:...:....::|....:..||...|:  ..||.::..:..|:.: .|...
Worm   883 NRKILEYTCQTAYFVSIVVVQWADLIISKTRRNSLVQQGMSNWTLNFGLVFETALAWFM-CYCPG 946

  Fly  1005 LYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVNDMYRKVPLKSKP 1058
            |.....:|.:  :|     .|.|       |.||..::..|.|..|:..::..|
Worm   947 LDNGLRMYGL--RF-----SWWF-------CALPFSILIFVYDEIRRFLIRRYP 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	6/31 (19%)
		ATPase-Plipid	28..1051	CDD:273734	231/1150 (20%)
		E1-E2_ATPase	84..>189	CDD:278548	23/110 (21%)
		Cation_ATPase	<489..568	CDD:289987	19/91 (21%)
		HAD_like	<758..807	CDD:304363	20/51 (39%)
		PhoLip_ATPase_C	804..1050	CDD:292829	59/317 (19%)
eat-6	NP_506269.1	ATPase-IIC_X-K	6..996	CDD:273445	233/1159 (20%)
		Cation_ATPase_N	18..92	CDD:214842	4/25 (16%)
		E1-E2_ATPase	112..343	CDD:278548	59/331 (18%)
		Cation_ATPase	404..494	CDD:289987	20/127 (16%)
		COG4087	<644..725	CDD:226572	28/98 (29%)
		Cation_ATPase_C	772..981	CDD:279079	47/233 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910