DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and catp-8

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_502165.2	Gene:	catp-8 / 178070	WormBaseID:	WBGene00007514	Length:	1178	Species:	Caenorhabditis elegans

Alignment Length:	1239	Identity:	243/1239 - (19%)
Similarity:	420/1239 - (33%)	Gaps:	398/1239 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LNRVTTTKYT--WFTF----------------------LPLNFY---------EQFRRAVYFY-- 56
            |.|.|..|.|  ||.|                      .|:.|:         |..:.|.|..
Worm   109 LMRTTRDKQTKLWFEFQRVHYTWDEESREFQTKTLDTAKPMVFFQKSHGFEVEEHVKDAKYLLGD 173

  Fly    57 ----FLIITIVSFFVNETISPL------------------VSLLPLLFVMII--TALKEGLEDYS 97
                .::...:..|:....:|.                  .||..|..:|..  |.:|:.:::.|
Worm   174 NKTEMIVPQFLEMFIERATAPFFVFQVFCVGLWCLEDMWYYSLFTLFMLMTFEATLVKQQMKNMS 238

  Fly    98 --RSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGD---VPCDLVLLQSSSADRKCF 157
              |:..:|   |..:.|:|..|.:.|..:.:|.||:|.:....:   |||||:||:.     .|.
Worm   239 EIRNMGNK---TYMINVLRGKKWQKIKIEELVAGDIVSIGRGAEEECVPCDLLLLRG-----PCI 295

  Fly   158 VNTANLDGETNLKTICVPTNYLLAGDHELQGKDCIVCEPSSADLYTFNGRLELRSGNDGAGSSAG 222
            |:.:.|.||:      ||.......|.|   ||.|....:.:.|:...|..::....  |...|.
Worm   296 VDESMLTGES------VPQMKEPIEDVE---KDKIFDIETDSRLHVIFGGTKIVQHT--APGKAA 349

  Fly   223 DALPLTIDNLLLRGVRVKSTERVVGC-AIYTGMHT---KLQLNSRYTGNKSASSEKYINRFMVAL 283
            :.:             |||.:....| .|.||.:|   ||.....:...|:.::......|::.|
Worm   350 EGM-------------VKSPDGNCICYVIRTGFNTSQGKLLRTIMFGVKKATANNLETFCFILFL 401

  Fly   284 IVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMVP-------- 340
            ::..|.....|::               :|......|.:::   ||...|:...::|
Worm   402 LIFAIAAAAYLWI---------------KGSVDETRSKYKL---FLECTLILTSVIPPELPIELS 448

  Fly   341 ---ISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNL 402
               .|:.|.::...||               ..:|.|:..:      |:|:|...|||||||.:
Worm   449 LAVNSSLMALQKLGIF---------------CTEPFRIPFA------GKVDICCFDKTGTLTTD- 491

  Fly   403 MKFVNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDADAAVLFEALAVCHTVEVLQE--VGDKTLE 465
                |..|.|.....|...::....|...|          ..:.||.||::...:|  |||
Worm   492 ----NLVVEGVALNNQKEGMIRNAEDLPHE----------SLQVLASCHSLVRFEEDLVGD---- 538

  Fly   466 SSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVL----SICRYPSAEKVQ 526
                                    |.|||.|..|.     :...:.|.:    :..:..|..|:
Worm   539 ------------------------PLEKACLSWCG-----WNLTKGDAVMPPKTAAKGISGIKI- 573

  Fly   527 FKRLHVLEFSSERQRMSVIVRDQ----SDTIWLYS-KGAESAIFPRCKASPLVEQTDAQITKYAQ 586
            |.|.|   |||..:||:|:...|    |||.::.: |||...:  |...:.|....|...|:..:
Worm   574 FHRYH---FSSAMKRMTVVAGYQSPGTSDTTFIVAVKGAPEVL--RNMYADLPSDYDETYTRLTR 633

  Fly   587 NGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEH 651
            .|.|.:|:|.|.|.:..:....:..|                 |..||:|...|...:...|:..
Worm   634 QGSRVLAMGIRKLGETRVGELRDKKR-----------------ENFENDLAFAGFVVISCPLKSD 681

  Fly   652 VGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDMIGDDE 716
            ....:..:..:...:.::|||...||.::....: ..:.|....:::  |||:   .:|.:...
Worm   682 TKTMIREIMDSSHVVAMITGDNPLTACHVSKVLK-FTKKSLPTLVLD--EPAD---GVDWMWKS- 739

  Fly   717 PEVLIVDGTTITAL----------------------------LEHTPRQF-ADLALRCRAVLCCR 752
                 ||||....|                            |.|....| .:|.|..:  :..|
Worm   740 -----VDGTIELPLKPETKNKMERKAFFNSHEFCLTGSAFHHLVHNEHTFLRELILHVK--VFAR 797

  Fly   753 LSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITG-------------------- 797
            ::|.||..|:..:|...| :|...|||.|||..::.|::|:.:..
Worm   798 MAPKQKERIINELKSLGK-VTLMCGDGTNDVGALKHANVGVALLTNPYDAEKAAEKEKEKKAKIE 861

  Fly   798 ------REGKQ---------------AAR---------------CADFSIARFEMLRRLF----- 821
                  |.|.|               |||               .|:.:.||.:.|.:..
Worm   862 EARSLVRSGAQLPQRPGAPGAPPAANAARRDAPPGARARAPLPPMANAAQARLDNLMKELEEEEK 926

  Fly   822 ---------LVHGHYNSQRLAFLVLFYCYKN---IIITGCMALYQVYDLYSATNVYNSIYLWLFD 874
                     .:...:.|:..:...:.:..|.   .::| .:.::::..|.:..:.|:...|:|..
Worm   927 AQVIKLGDASIAAPFTSKYTSIASICHVIKQGRCTLVT-TLQMFKILALNALVSAYSLSALYLDG 990

  Fly   875 IVYISFSFTV----LAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFF- 934
            :.:.....|:    ||.|....|:...|......:|:|:       :|:.:.|......||:.|
Worm   991 VKFSDTQATIQGLLLAACFLFISKSKPLKTLSRQRPMAN-------IFNAYTLLTVTLQFIVHFS 1048

  Fly   935 ---FTYAMLNDANVLFNGGQTASFQ---TFGTMLITIIVIVGNLKLLLVAHYMTYR--------- 984
               :...:.::||.     :.|...   .|...::...|.:.::.|.:....:.||
Worm  1049 CLLYIVGLAHEANT-----EKAPVDLEAKFTPNILNTTVYIISMALQVCTFAVNYRGRPFMESLF 1108

  Fly   985 -NFAMILASI----AAFMLTTYLYNLYTSGELYDVYNQF-LSSLPIWLFTIICSVACLLPDFVIK 1043
             |.||:.:.:    |.|.|        .||:..|:..|| |..||..|...:  :.|:..|.||.
Worm  1109 ENKAMLYSIMFSGGAVFTL--------ASGQATDLMIQFELVVLPEALRNAL--LMCVTADLVIC 1163

  Fly  1044 VVND 1047
            .:.|
Worm  1164 YIID 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	13/77 (17%)
		ATPase-Plipid	28..1051	CDD:273734	242/1238 (20%)
		E1-E2_ATPase	84..>189	CDD:278548	31/111 (28%)
		Cation_ATPase	<489..568	CDD:289987	25/87 (29%)
		HAD_like	<758..807	CDD:304363	19/104 (18%)
		PhoLip_ATPase_C	804..1050	CDD:292829	54/302 (18%)
catp-8	NP_502165.2	P-ATPase-V	37..1153	CDD:273738	238/1223 (19%)
		E1-E2_ATPase	251..>380	CDD:278548	41/157 (26%)
		Cation_ATPase	532..613	CDD:289987	29/117 (25%)
		COG4087	<793..>842	CDD:226572	16/51 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910