DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and tat-2

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001294447.1	Gene:	tat-2 / 177256	WormBaseID:	WBGene00019166	Length:	1349	Species:	Caenorhabditis elegans

Alignment Length:	1134	Identity:	343/1134 - (30%)
Similarity:	557/1134 - (49%)	Gaps:	172/1134 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVN-ETISPLVSLLPLLFVMIITALKE 91
            |.:.|:||...||:|.|.:|||:|...||||::.|:.|... .:||...:.:||:.|:..:|:|:
Worm    74 NVIKTSKYNIITFIPQNLFEQFQRIANFYFLVLMILQFIPQISSISWYSTAVPLVIVLAFSAIKD 138

  Fly    92 GLEDYSRSKSDKLVNTARVTVIRNG---KEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSAD 153
            |.:|..|..||:.||..:..|:|||   :|:..|   :..||::.:.::..|..||:||.:|...
Worm   139 GYDDAQRHISDRNVNGRKSYVVRNGSLCEEDWSN---VKVGDVIRMMSNQFVAADLLLLSTSEPY 200

  Fly   154 RKCFVNTANLDGETNLKTICVPTNYLLAGDHELQGKDC---------IVCEPSSADLYTFNGRLE 209
            ..||:.|..||||||||     ....:|...|: |.|.         |:|||.:..|..|||:|.
Worm   201 GVCFIETMELDGETNLK-----NRAAIACTQEM-GDDLDGITRFDGEIICEPPNNKLDKFNGKLI 259

  Fly   210 LRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEK 274
            ..:...|..:          ||:||||..:|:|....|..::.|..|||.:||..|..|..|.::
Worm   260 WNNHEYGVNN----------DNILLRGCILKNTRWCYGVVVFAGKDTKLMMNSGKTKFKRTSLDR 314

  Fly   275 YINRFMVALI---VGMIVVVVVLYLIERHKEAK----------IVPTMPYQGPPTNFNSAWQIFE 326
            ::|..:|.::   :.|.::..:|..:..::..:          :||:...:|   ....|...|.
Worm   315 FLNILIVGIVLFLIAMCLICTILCAVWEYQTGRYFTIYLPWDDVVPSPEQRG---GRQIALIAFL 376

  Fly   327 DFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDE--ETDQPCRVNASNLNEELGQVNI 389
            .|.|:::|.|.:||||.|:::|:.|.....:::.|..:|.|  |...|.:.:.:.||||||||..
Worm   377 QFFSYIILLNTVVPISLYVSVEIIRFIHSLWINYDTQMYYENGEKSVPAKAHTTTLNEELGQVQY 441

  Fly   390 LFSDKTGTLTKNLMKFVNCYVPGTNY--------QLQNT-----------HLVSEGTDEKFELEK 435
            :|||||||||:|:|.|..|.:.|.:|        ::..|           :..||.|.:.|:...
Worm   442 VFSDKTGTLTRNIMTFNKCTINGISYGDIYDHKGEVIETNDKTKSLDFSWNSASEPTFKFFDKNL 506

  Fly   436 LDA------DAAVLFEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKA 494
            :||      :....:..||:||||...::.|...                     |||.||||.|
Worm   507 VDATKRQVPEIDQFWRLLALCHTVMPERDKGQLV---------------------YQAQSPDEHA 550

  Fly   495 LLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKG 559
            |.....:.|.|:..:....::|....:.|..:.  |.:|:|:::|:||||||:.....|.||.||
Worm   551 LTSAARNFGYVFRARTPQSITIEVMGNEETHEL--LAILDFNNDRKRMSVIVKGPDGKIRLYCKG 613

  Fly   560 AESAIFPRCKASP---LVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNR 621
            |:..|..|...|.   :...|:..:..:|..||||:.:|.:.|.......::...:||:..:.:|
Worm   614 ADMMIMQRIHPSTSQIMRTSTNTHLADFANIGLRTLCLGYKDLDPAYFSDWDSRVKKASAAMQDR 678

  Fly   622 NELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRH 686
            ...:.:.||.:|.:|.|:||||:||.||:.|.|.:..|..|.:|||||||||.|||.||..:||.
Worm   679 ESAVDALYEEIEKDLILIGATAIEDKLQDGVPEAIARLSEANIKIWVLTGDKTETAINIAYSCRL 743

  Fly   687 IPRGSKQHFII----------------NTTEPAELLARLDMIG----------DDEPE------- 718
            :...:|:..::                ||.|  ::||....:|          .:|.|
Worm   744 LTDETKEIVVVDGQTDTEVEVQLKDTRNTFE--QILALPSPLGGKPRIEIETIHEESEAISSARS 806

  Fly   719 -----------------------VLIVDGTTIT-ALLEHTPRQFADLALRCRAVLCCRLSPLQKS 759
                                   .|:::|.::. ||.....|.|.::|..|.||:|||::||||:
Worm   807 MDRNIVTPDLKSAEMAEHESGGVALVINGDSLAFALGPRLERTFLEVACMCNAVICCRVTPLQKA 871

  Fly   760 EIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVH 824
            ::|.|:||.||.:|.:|||||||||||:.||||:||:|:||.||...:|:||.:|:.|.||.|||
Worm   872 QVVDLVKRNKKAVTLSIGDGANDVSMIKTAHIGVGISGQEGMQAVLASDYSIGQFKYLERLLLVH 936

  Fly   825 GHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICD 889
            |.::..|:|..:.::.|||...|.....|..:..|||..|::::.:..:::.:.:.....:...|
Worm   937 GRWSYIRMAKFLRYFFYKNFAFTLTNFWYSFFCGYSAQTVFDAVLIACYNLFFTALPVLAMGSLD 1001

  Fly   890 KDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTY-AMLNDANVLFNGGQTA 953
            :|..:...|.:|:||.|...|...:|.:|...:|:|.....:|||..| |..|.|..........
Worm  1002 QDVDDHYSLRYPKLYLPGQFNLFFNMRIFIYSVLHGMFSSLVIFFIPYGAFYNAAAASGKDLDDY 1066

  Fly   954 SFQTFGTMLITIIVIVGNLKL-----LLVAHYMTYRNFAMILASIAAFMLTTYL---YNLYTSGE 1010
            |...|.|....::|:.|.:..     ..::|::.:.  :::|..:..|:|..:|   :.:.||..
Worm  1067 SALAFTTFTALVVVVTGQIAFDTSYWTAISHFVIWG--SLVLYFLVCFLLYEWLPVSWIVKTSSS 1129

  Fly  1011 L-YDVYNQFLSSLPIWLFTIICSVACLLP 1038
            : |.|..:.:.:...|...::.||..|||
Worm  1130 ISYGVAFRTMVTPHFWFSILMVSVVLLLP 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	17/37 (46%)
		ATPase-Plipid	28..1051	CDD:273734	343/1134 (30%)
		E1-E2_ATPase	84..>189	CDD:278548	36/107 (34%)
		Cation_ATPase	<489..568	CDD:289987	27/78 (35%)
		HAD_like	<758..807	CDD:304363	30/48 (63%)
		PhoLip_ATPase_C	804..1050	CDD:292829	61/245 (25%)
tat-2	NP_001294447.1	PhoLip_ATPase_N	60..122	CDD:292826	20/47 (43%)
		ATPase-Plipid	71..1178	CDD:273734	343/1134 (30%)
		Cation_ATPase	526..615	CDD:289987	33/111 (30%)
		R3H	675..738	CDD:294210	31/62 (50%)
		HAD_like	<885..916	CDD:304363	22/30 (73%)
		PhoLip_ATPase_C	916..1172	CDD:292829	61/245 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820