DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and tat-3

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_499363.3	Gene:	tat-3 / 176498	WormBaseID:	WBGene00012360	Length:	1411	Species:	Caenorhabditis elegans

Alignment Length:	1284	Identity:	372/1284 - (28%)
Similarity:	600/1284 - (46%)	Gaps:	281/1284 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISPLVSLLPLLFVMIITALKEG 92
            ||::||||:..||:|.|.:||..||...||:.|.|::..:. .....:|:||:.||:.|||:|:.
Worm   106 NRISTTKYSVLTFIPKNLFEQLHRAANLYFIFIVILNMIIG-AFGKYISVLPIAFVLGITAIKDA 169

  Fly    93 LEDYSRSKSDKLVN--TARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRK 155
            .|||.|.|||:.:|  |.||......:...:..|.|:.||.|.:.:|..:|.|::||:||..:..
Worm   170 FEDYRRYKSDQKINHSTCRVWDASQQRYRKLEWQNILVGDFVHLSHDEIIPADILLLRSSDVNGV 234

  Fly   156 CFVNTANLDGETNLK------------TICVPTNYLLAGDHELQGKDCIVCEPSSADLYTFNGRL 208
            |:|.|.|||||:|||            ...||..|..|   |...:  |.||..:.|:|.|.|||
Worm   235 CYVETCNLDGESNLKQRQAIRSMGKYHNANVPLEYSPA---EFNYR--IACEQPTTDVYKFEGRL 294

  Fly   209 ELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSE 273
            |   ..:|....|.:...|..:|:||||..||:|:.|.|..:|.|..||..||:.....|.:|.|
Worm   295 E---AIEGGPPLAREFTILAKENVLLRGCVVKNTDFVEGIVLYAGKDTKAMLNNNGPRYKRSSLE 356

  Fly   274 KYIN---RFMVALIVGMIVVVVVL--YLIERHKEAKIVPTMPYQGPPTNFNS----------AWQ 323
            |..|   .:.|..::.:.|:..||  ..:.......|||.:.:..|.:::::          :::
Worm   357 KMTNVDILWSVCTLLALCVIGAVLSGVWLRTFSTPYIVPFLVFIHPNSSYHNNNDSQYKYSPSYE 421

  Fly   324 IFEDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVN 388
            .:..|.|::::...|:|||.|::||..:||.:.||..|.::|.::.|:..:..|.|:.|||||:.
Worm   422 SWFSFWSYIIVLQVMIPISLYVSIEFIKIFQVWFMSQDRNMYYDKVDKRLQCRALNITEELGQIQ 486

  Fly   389 ILFSDKTGTLTKNLMKFVNCYVPGTNY--------------QLQNTHLVSEGTDEKFELE----- 434
            .:.||||||||:|.|.|..|.|.|.:|              .:.:|....:.|::|.::.
Worm   487 YVMSDKTGTLTENQMVFRRCSVNGNDYGGRPVVDAVDSSLELVASTLRSDQPTEKKLQMAALAEA 551

  Fly   435 ------------------------KLDAD----AAVLFEALAVCHTVEV---------------- 455
                                    ||.||    ....|..:|:|:||.|
Worm   552 AAKTRRLRPSRDPALESQLASSVLKLGADIDDPVFAFFLTMAICNTVVVNAKPHEDLMDPDGDIV 616

  Fly   456 -----------------------LQEVGDKTLESSES---------------------------- 469
                                   |.:|.:::..|:::
Worm   617 NSRFAPEEVSPRRGSSLEDGFKYLADVEEESPASTQASTPVMITEENDGFEEIELIEFPEVKTDE 681

  Fly   470 --VSEQSHLMS--------------------------------------------------RNIV 482
              ::|:...:|                                                  |..|
Worm   682 TQMTEKEETISAEVAAKKSGSDEKDNNYNGERKEGKGFGILHRPSILSVPFAKLKGMKSPFRRSV 746

  Fly   483 DR-----------------YQASSPDEKALLEGCASLGL-VYEGQENDVLSICRYPSAEKVQFKR 529
            |:                 |.:.||||.||:|.....|: :...:.:||:...|: |...|::|.
Worm   747 DKRSSSSTETAVAPPLHSFYDSESPDELALVEAAREYGIRLLRRRFDDVIVYLRH-STSSVKYKV 810

  Fly   530 LHVLEFSSERQRMSVIVRDQS--DTIWLYSKGAESAIFP--------RCKASPLVEQTDAQITKY 584
            ||.|.|.::|:|||||:|:.|  ..|.:.:|||::.:.|        ..:...::.::...:|:|
Worm   811 LHTLPFDADRKRMSVIIRESSGLKRIIVLTKGADATVIPVLSEAFSTSARGEEVIFKSQEHLTQY 875

  Fly   585 AQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQ 649
            |:.||||:.:..::.|::|...::|.:.:|...:.::..::|......|.:|:|||.||:||.||
Worm   876 AKEGLRTLCLSMKIWTEEEYQGWKEKHEEAELDMMDKETMLAESTLRAEQDLELLGVTAIEDRLQ 940

  Fly   650 EHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIIN------------TTEP 702
            :.|.|.:.:|:.||:::|||||||:|||.||..:.|..   |....::|            .||.
Worm   941 DGVPECIHSLREAGIRVWVLTGDKIETAVNIAYSSRLF---SPSMDLLNIGANGVRAVSDLLTEH 1002

  Fly   703 AELLARLDMIGDDEPEV--LIVDGTTITALLE-HTPRQFADLALRCRAVLCCRLSPLQKSEIVTL 764
            .:.:||...:..|..:.  |:::.:|::..|: |...:|..|...||:|||||.:||||:::|.|
Worm  1003 LKRIARAYEVSADAADSFGLVLNASTMSYCLDPHNLERFVKLLRGCRSVLCCRATPLQKAQLVNL 1067

  Fly   765 IKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNS 829
            .|...|....|||||||||||||.|.:|||::|:||.||...:||::|||..|..|.|||||:|.
Worm  1068 AKNHLKGKVLAIGDGANDVSMIQGADVGIGLSGQEGMQAVMSSDFAMARFRFLSNLLLVHGHWNY 1132

  Fly   830 QRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSE 894
            .|||..:|::.|||.::...:..||:::.:||....:.:||.::::::.|....:....|:|.|.
Worm  1133 YRLAQTILYFFYKNAMLVFVIFWYQIFNGFSAQVPIDPVYLMVYNLIFTSVPPLLFGCLDQDASA 1197

  Fly   895 ETLLSHPELYKPLAHNRQASMGV----FSLWI--LNGFVQCFIIFFFTYAMLNDANVLFNGGQTA 953
            |.||..|.||:      |..:|.    :|.||  |:...|..::||..|.....:||
Worm  1198 ELLLDCPRLYE------QGRLGKRYRWYSFWINMLDAVWQSLVVFFICYFTYRGSNV-------- 1248

  Fly   954 SFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYTSG-----ELYD 1013
            ...|||.:|:|.::||....|.|...|.|:..|..:..|:..|.:...|||.:.:.     .:.|
Worm  1249 DMWTFGHLLVTQLIIVNTFHLALFVQYWTWPMFWSMFLSVLLFFICALLYNGFVTANWTWTNVKD 1313

  Fly  1014 ----VYNQFLSSLPIWLFTIICSVACLLPDFVI-KVVNDMYRKVPLKSK 1057
                |..:..|||..|:..||..|.||.|.:|: .|||.:.....|:::
Worm  1314 PPSMVSLKSFSSLEFWMALIISVVLCLTPRYVLTTVVNTVSPSTTLRTR 1362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/37 (49%)
		ATPase-Plipid	28..1051	CDD:273734	371/1276 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	43/118 (36%)
		Cation_ATPase	<489..568	CDD:289987	31/89 (35%)
		HAD_like	<758..807	CDD:304363	27/48 (56%)
		PhoLip_ATPase_C	804..1050	CDD:292829	81/261 (31%)
tat-3	NP_499363.3	PhoLip_ATPase_N	94..152	CDD:292826	18/46 (39%)
		ATPase-Plipid	103..1357	CDD:273734	371/1277 (29%)
		Cation_ATPase	<770..848	CDD:289987	30/78 (38%)
		HAD_like	<1075..1107	CDD:304363	21/31 (68%)
		PhoLip_ATPase_C	1107..1356	CDD:292829	81/262 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4775
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820