DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and tat-4

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001379745.1	Gene:	tat-4 / 174031	WormBaseID:	WBGene00020784	Length:	1212	Species:	Caenorhabditis elegans

Alignment Length:	1191	Identity:	344/1191 - (28%)
Similarity:	553/1191 - (46%)	Gaps:	238/1191 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRA---VYFYFL-IITIVSFFVNETISPLVSLLPLLFVMIITA 88
            ||::|||||::.|:|||.:.|....   :||.|: |:..|.||  :..:..|.|:|:.||:..|.
Worm    66 NRISTTKYTFWNFIPLNIWHQVSTKYANLYFIFIAILNWVPFF--DAYTRYVGLIPICFVLGTTL 128

  Fly    89 LKEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQ--FIVPGDLVVVRNDGDVPCDLVLLQSSS 151
            :|:|:|||.|.|.|..:|.....|....:.....::  :|:.||.|.:.|:.|||.|::||:|||
Worm   129 IKDGIEDYRRYKFDNQINKKTCHVWDRDRCAFRKTEWRYILVGDFVHISNNQDVPADIILLRSSS 193

  Fly   152 ADRKCFVNTANLDGETNLKTICVPTNYLLAGDHELQGKD----------CIVCEPSSADLYTFNG 206
            ....|::.|.||||||:||...||...:     :...||          .:.||.....:||...
Worm   194 ESGTCYIETCNLDGETSLKQRMVPAKVI-----DYSKKDSTFKPPDFTGVVTCEKPDKSIYTIRA 253

  Fly   207 RLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSAS 271
            ::|...|....         :..:|:||||.|:|:|..|.|..:|.|..||:..|:....:|::.
Worm   254 KVEFEPGQSDV---------IIKENMLLRGSRIKNTTFVEGIVVYAGHDTKVMQNNGRAPHKTSG 309

  Fly   272 SEKYINRFMVALIVGMIVVVVVLY-------LIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFL 329
            .||..|:|::|..:  :::::|||       .:.:|...:.:|.: ....|..|      .|.|:
Worm   310 IEKLTNKFIIACFI--MLLLMVLYGAITSAVWVGQHPVDEQIPFI-LSNTPRPF------IEGFI 365

  Fly   330 ---SFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILF 391
               :|.:.:..:||||.|:.:|:.:...::|:.||:.|||:::|:.....:.::.||||.|..:.
Worm   366 GIGAFFINYQLLVPISLYITVEIIKALQIYFISNDIQLYDQKSDRAIDCRSLSIPEELGTVTHVL 430

  Fly   392 SDKTGTLTKNLMKFVNCYVPGTNY------------------------QLQN------------- 419
            ||||||||:|:|.|.||....|:|                        .:||
Worm   431 SDKTGTLTENMMIFRNCAFDETDYGSNGSQSNPDKPVKSDELYQRILTSMQNPVQKHFFANILLN 495

  Fly   420 ----------THLVSEG-----------------TDEKFELEKLDA------------------- 438
                      |.::..|                 |:||:: :||.|
Worm   496 NSVVVNHIPHTDVLELGNFDGGVYNIGNSCFYDVTEEKYK-QKLAAIGKGGVDDDDVSRPDELGL 559

  Fly   439 -DAAVLFEALAVCHTVEVLQEVGD-----------------------KTLESSESVSEQ-SHLMS 478
             ..::.|:...   ||.|.::...                       :.|.|..|.|.: |.::.
Worm   560 PTTSIQFDDRL---TVIVEEDTPSDSPAPDASPRDLPETPTPTSPIYRPLSSLSSFSRKLSTVVR 621

  Fly   479 RNI---------------------VDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSA 522
            |:|                     ::.|:|.||||.||:||.|....|...:....::|.....|
Worm   622 RSILRPISDIIPVRKRLISFKQQAMNPYEAESPDELALIEGAALYDYVLLERAATSVTISTPEKA 686

  Fly   523 EKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKASPL----VEQTDAQITK 583
            || :::.|..|.|.:.|:||||||..|...: :|.|||:|||..|..:..|    |:.....:..
Worm   687 EK-RYEILLTLPFDATRKRMSVIVNSQKGPL-MYCKGADSAIISRLSSDSLESKRVQDLKDHLDN 749

  Fly   584 YAQNGLRTMAVGRRMLTDDELFHFEELYR-KANTQLSNRNELIASCYETVENELDLLGATALEDA 647
            ||:.||||:....:.::.::...|.:.|| ......|.|.::::...:.:|..|.|.|.|.:||.
Worm   750 YAKKGLRTLCFAMKYISKEDFEDFLDSYRFLMEDATSEREKMLSEKADELETNLKLSGVTGIEDR 814

  Fly   648 LQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACR--HIPRGSKQHFIINT---TEPAELLA 707
            ||:.|.:||.||:.||:::|||||||:|||.||..:..  |..|..|   :|.|   .|.|...|
Worm   815 LQDGVPDTLRALRDAGIQVWVLTGDKLETAQNIATSSGLFHPQRSLK---VIETETDAEEASESA 876

  Fly   708 RLDMIGDDEPEVLIVDGTTITALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYI 772
            .|::|.......|..||..          ...:...:.:.|||.|::|.:|:.||..:|:|.|..
Worm   877 GLNIIMSPAAIRLAQDGNA----------HLMEALKKAKTVLCYRMTPSEKATIVNTVKKRIKGN 931

  Fly   773 TAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVL 837
            ..|||||||||.|||.||:||||.|:||.|||...||:||||:.|.||.|||||::..|||...|
Worm   932 VLAIGDGANDVPMIQAAHVGIGIAGKEGLQAAMACDFAIARFKFLSRLLLVHGHWSYYRLANTFL 996

  Fly   838 FYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPE 902
            ::.|||......:..||.|:..|.||:.:.|:..::.|::.|....|:.:.|:||.::||::.||
Worm   997 YFLYKNANAVFIIFYYQFYNGASGTNIVDPIWGVIYPIIFTSVQPVVVGVLDQDYDDQTLMNKPE 1061

  Fly   903 LYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIV 967
            ||.....|:..:...|...:::|..|..:|::..|..|:::        |:|....|..:.|..:
Worm  1062 LYVIGRENQLYTWKHFFRDVIDGIYQAAVIYYVAYLTLDNS--------TSSLWEMGFYIATSSI 1118

  Fly   968 IVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNL-YTSGELYDVYNQFLSSLPIWL----- 1026
            :|.:..|.|...|..::     |.::.:|.:   |:|. :...|........:...|:|:
Worm  1119 LVNSGHLALQVRYWHWQ-----LVALFSFFI---LFNFAFFFAECLTAAAAMVPDPPVWMPIHAM 1175

  Fly  1027 -------FTIICSVACLLPDF 1040
                   :..|..:..|.|.|
Worm  1176 GDPRFWYYQFITVIVALCPRF 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	17/41 (41%)
		ATPase-Plipid	28..1051	CDD:273734	344/1191 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	37/106 (35%)
		Cation_ATPase	<489..568	CDD:289987	32/78 (41%)
		HAD_like	<758..807	CDD:304363	30/48 (63%)
		PhoLip_ATPase_C	804..1050	CDD:292829	67/250 (27%)
tat-4	NP_001379745.1	P-type_ATPase_APLT_Dnf-like	65..1095	CDD:319770	323/1072 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4775
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920