DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and tat-5

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_001021457.1	Gene:	tat-5 / 172748	WormBaseID:	WBGene00009498	Length:	1074	Species:	Caenorhabditis elegans

Alignment Length:	1060	Identity:	315/1060 - (29%)
Similarity:	534/1060 - (50%)	Gaps:	127/1060 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETI-SPLVSLLPLLFVMIITALKE 91
            |.|...||..|:|:|:..::||:..:..|||::....|.....| :|:....||.||:.||.::|
Worm   106 NTVCNQKYNIFSFVPIVLFQQFKFFLNLYFLLMACSQFIPAIQIGAPITYWGPLGFVLTITLIRE 170

  Fly    92 GLEDYSRSKSDKLVNTARV-TVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRK 155
            ..:|:.|...|:.:|:.:. .:.|:|....|.|..|..||::::..|..||.|:|||:::.....
Worm   171 AFDDFVRYLRDRDLNSEKYEKLTRDGTRIEIRSADIEVGDVIIMHKDRRVPADVVLLRTTDKSGA 235

  Fly   156 CFVNTANLDGETNLK-TICVPTNYLLAGDHELQGKDC-IVCEPSSADLYTFNGRLELRSGN---D 215
            ||:.|..|||||:.| .|.||....|..:.::...:| :..|....|::.|.|.|::...:   |
Worm   236 CFIRTDQLDGETDWKLRIPVPHTQHLPNEADIMELNCEVYAEKPQKDIHAFVGTLKITDDDNVQD 300

  Fly   216 GAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFM 280
            |:         |.::|:|.... |.::...||..:|||..|:..:|:....:|....:..:|...
Worm   301 GS---------LNVENVLWANT-VVASGTAVGIVVYTGRETRSVMNTTLPESKVGLLDLEVNNLT 355

  Fly   281 VALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMVPISAYM 345
            ..|...::|:..|:..::                  ..::.|  :...:.|:|||:|::|||..:
Worm   356 KLLFCFVLVLSSVMVAMK------------------GLDNLW--YRYLMRFILLFSYIIPISLRV 400

  Fly   346 NIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVNCYV 410
            |:::.::|....:..|.|:  .||    .:.:|.:.||||:::.|.||||||||||.|.|...::
Worm   401 NLDMAKLFYSWQIGRDKHI--PET----VIRSSTIPEELGRISFLLSDKTGTLTKNEMHFKKIHL 459

  Fly   411 PGTNYQLQNTHLVSEGTDEKF--ELEKLDADAAV--LFEALAVCHTVEVLQEVGDKTLESSESVS 471
            ....:.......|.:.....:  .|.|....|.:  ..||:|:||.|..:.|.|:.:
Worm   460 GTVAFSSDAFEEVGQHVRSAYAGRLAKHSFSAKLQNAVEAIALCHNVTPIFENGEIS-------- 516

  Fly   472 EQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSI-CRYPSAEKV--QFKRLHVL 533
                         |||:||||.||::...::|:....::...:|: .:.|:.:.:  ||:.|:|.
Worm   517 -------------YQAASPDEVALVKWTETVGVRLASRDLHAMSLSVQLPNGQTLMKQFQILYVF 568

  Fly   534 EFSSERQRMSVIVRDQ-SDTIWLYSKGAESAIFPRCKASPLVEQT---DAQITKYAQNGLRTMAV 594
            .|:||.:||.:||:|: :|.:.|..|||::.:      |.:|:..   |.:.:..|:.||||:.|
Worm   569 PFTSETKRMGIIVKDETTDEVTLLMKGADTVM------SGMVQYNDWLDEECSNMAREGLRTLVV 627

  Fly   595 GRRMLTDDELFHFEELYRKANTQLSNRNELIASCY-ETVENELDLLGATALEDALQEHVGETLEA 658
            .|:.|:..||..|:..|..|...:|:|::.:|:.. ..:|.:|.||..|.:||.||:.|..:||.
Worm   628 ARKPLSQAELEAFDRAYHAAKMSISDRSQNMANVVNRMLERDLQLLCLTGVEDRLQDQVTTSLEL 692

  Fly   659 LQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDMIGDDEPEVLIVD 723
            |:.||:|||:|||||:|||..|..:.....|....|...|.....:....|:.:.......|::.
Worm   693 LRNAGIKIWMLTGDKLETAICIAKSSGLFSRSDNIHVFGNVHNRTDAHNELNNLRRKTDVALVMP 757

  Fly   724 GTTITALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKR-RKKYITAAIGDGANDVSMIQ 787
            |:.:...|::...:.|:|...|.||:|||.||.||::||.|::: |.....||||||.|||||||
Worm   758 GSALNVCLQYYEAEVAELVCACTAVVCCRCSPEQKAQIVQLLRKYRAPLRVAAIGDGGNDVSMIQ 822

  Fly   788 EAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMAL 852
            .||.||||...|||||:..|||||.:|..:.||.||||.:..:|...|..|..::.:||:...|:
Worm   823 AAHAGIGIDANEGKQASLAADFSITQFSHVCRLLLVHGRFCYKRSCALSQFVMHRGLIISTMQAI 887

  Fly   853 YQVYDLYSATNVYNSIYLWLFDIVYIS---FSFTVLAICDKDYSEETLLSHPELYKPLAHNRQAS 914
            :.....:::.::|..:.:..:...|..   ||..|    |:|.:....|::|||||.|...|..|
Worm   888 FSCVFYFASVSLYQGVLMVAYSTCYTMLPVFSLVV----DRDVTATNALTYPELYKELGKGRSLS 948

  Fly   915 MGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAH 979
            ...|.:|:|....|..:|.:.. .::.||:.:    ...|. :|..:::|        :|::||.
Worm   949 YKTFCIWVLISLYQGAVIMYGA-LLVFDADFI----HVVSI-SFSALIVT--------ELIMVAM 999

  Fly   980 YMTYRNFAMILA---SIAAFMLTTYLYNLYTSGELYDVYNQFLSSLPIWLF----TIICSVACLL 1037
            .:...::||:||   |:..:|::..|::.|     :|  .||:.|   |:|    |.|.:|:| |
Worm  1000 TVHTWHWAMLLAQALSLGLYMISLILFDQY-----FD--RQFVLS---WVFISKTTAITAVSC-L 1053

  Fly  1038 PDFVIKVVN-----DMYRKV 1052
            |.:::|.:.     ..|.||
Worm  1054 PLYIVKALRRKFSPPSYAKV 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	12/37 (32%)
		ATPase-Plipid	28..1051	CDD:273734	313/1057 (30%)
		E1-E2_ATPase	84..>189	CDD:278548	34/106 (32%)
		Cation_ATPase	<489..568	CDD:289987	26/82 (32%)
		HAD_like	<758..807	CDD:304363	29/49 (59%)
		PhoLip_ATPase_C	804..1050	CDD:292829	68/260 (26%)
tat-5	NP_001021457.1	ATPase-Plipid	103..1073	CDD:273734	313/1058 (30%)
		PhoLip_ATPase_N	<103..154	CDD:292826	15/47 (32%)
		E1-E2_ATPase	161..400	CDD:278548	69/268 (26%)
		Cation_ATPase	502..600	CDD:289987	34/118 (29%)
		HAD_like	<792..834	CDD:304363	24/41 (59%)
		PhoLip_ATPase_C	839..1067	CDD:292829	68/256 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920