DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and ATP8B3

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_006722717.1	Gene:	ATP8B3 / 148229	HGNCID:	13535	Length:	1310	Species:	Homo sapiens

Alignment Length:	1152	Identity:	337/1152 - (29%)
Similarity:	564/1152 - (48%)	Gaps:	161/1152 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RQQKPLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISPLVSL-LPLLFVMI 85
            |::...|.:.|.||.:::|||||.||||.|....:||||.|:....:.:..|..|| .|::.::.
Human   130 RKKYKTNVIRTAKYNFYSFLPLNLYEQFHRVSNLFFLIIIILQSIPDISTLPWFSLSTPMVCLLF 194

  Fly    86 ITALKEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSS 150
            |.|.::.::|..|.|||:.:|.....::.....:....|.:..||:|.:|.|..||.|::||.|:
Human   195 IRATRDLVDDMGRHKSDRAINNRPCQILMGKSFKQKKWQDLCVGDVVCLRKDNIVPADMLLLAST 259

  Fly   151 SADRKCFVNTANLDGETNLK--TICVPTNYLLAGDHEL---QGKDCIVCEPSSADLYTFNGRLEL 210
            .....|:|.|.::|||||||  ...:.|:..||...::   ||  .:.||..::.::.|.|.||
Human   260 EPSSLCYVETVDIDGETNLKFRQALMVTHKELATIKKMASFQG--TVTCEAPNSRMHHFVGCLE- 321

  Fly   211 RSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKY 275
              .||...|       |.|.||||||.|:::|:...|..||.|..||:..|......|....:..
Human   322 --WNDKKYS-------LDIGNLLLRGCRIRNTDTCYGLVIYAGFDTKIMKNCGKIHLKRTKLDLL 377

  Fly   276 INRFMVALIVGMIVVVVVL-----YLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLF 335
            :|:.:|.:.:.:::|.:||     :.::..|:...     |.......:.|.:.|..|.|||:|.
Human   378 MNKLVVVIFISVVLVCLVLAFGFGFSVKEFKDHHY-----YLSGVHGSSVAAESFFVFWSFLILL 437

  Fly   336 NYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTK 400
            :..:|:|.::..|...:....|:..|:.:|.:..|.|.:..:::||:.||||..:|||||||||:
Human   438 SVTIPMSMFILSEFIYLGNSVFIDWDVQMYYKPQDVPAKARSTSLNDHLGQVEYIFSDKTGTLTQ 502

  Fly   401 NLMKFVNCYVPG---------TNYQLQNTHLVSEGTDEK--------FELEKLDADAAV--LFEA 446
            |::.|..|.:.|         |....:|.:|.::..|.|        ..|.:.:.|.||  .:..
Human   503 NILTFNKCCISGRVYGPDSEATTRPKENPYLWNKFADGKLLFHNAALLHLVRTNGDEAVREFWRL 567

  Fly   447 LAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQEN 511
            ||:||||.|           .||..|:...:      .|||:||||.||:....:.|.|:..:..
Human   568 LAICHTVMV-----------RESPRERPDQL------LYQAASPDEGALVTAARNFGYVFLSRTQ 615

  Fly   512 DVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKASPLVE- 575
            |.::|...  .|:..::.|.:::|:|.|:||||:||.....|.||:|||::.||.|......:|
Human   616 DTVTIMEL--GEERVYQVLAIMDFNSTRKRMSVLVRKPEGAICLYTKGADTVIFERLHRRGAMEF 678

  Fly   576 QTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLG 640
            .|:..:..:||..|||:.:..|.:.:|....:::.:::|:..|.||.:.:...|..:|.:|.|||
Human   679 ATEEALAAFAQETLRTLCLAYREVAEDIYEDWQQRHQEASLLLQNRAQALQQVYNEMEQDLRLLG 743

  Fly   641 ATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAEL 705
            |||:||.||:.|.||::.|:.:.:|||||||||.|||.|||.||..:   |:...|:...|.:.:
Human   744 ATAIEDRLQDGVPETIKCLKKSNIKIWVLTGDKQETAVNIGFACELL---SENMLILEEKEISRI 805

  Fly   706 L------------------ARLDMI--GD----------DEPEVLIVD----------------- 723
            |                  .:|.::  ||          .||..|..:
Human   806 LETYWENSNNLLTRESLSQVKLALVINGDFLDKLLVSLRKEPRALAQNVNMDEAWQELGQSRRDF 870

  Fly   724 -------------GTTITA-------------LLEHTPRQFADLALRCRAVLCCRLSPLQKSEIV 762
                         |..:.|             :|:.  |.|.|||.:|:||:|||::|.||:.||
Human   871 LYARRLSLLCRRFGLPLAAPPAQDSRARRSSEVLQE--RAFVDLASKCQAVICCRVTPKQKALIV 933

  Fly   763 TLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHY 827
            .|:|:..:.:|.||||||||::||:.|.:|:|:.|:||.||.:.:||.:.:|..|:||.||||.:
Human   934 ALVKKYHQVVTLAIGDGANDINMIKTADVGVGLAGQEGMQAVQNSDFVLGQFCFLQRLLLVHGRW 998

  Fly   828 NSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDY 892
            :..|:...:.::.||::........:..|:.::...:|...:|.||:::|.:.....:.:.::|.
Human   999 SYVRICKFLRYFFYKSMASMMVQVWFACYNGFTGQPLYEGWFLALFNLLYSTLPVLYIGLFEQDV 1063

  Fly   893 SEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASF-- 955
            |.|..|..||||.....:...:..||...|.:|.....:.||.|..:..|.      ...|||
Human  1064 SAEQSLEKPELYVVGQKDELFNYWVFVQAIAHGVTTSLVNFFMTLWISRDT------AGPASFSD 1122

  Fly   956 -QTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIA--AFMLTT----YLYNLYTSGELYD 1013
             |:|..::....::...::::|:..|.|....|.||.|:.  |.|.||    :|:.:..:...:.
Human  1123 HQSFAVVVALSCLLSITMEVILIIKYWTALCVATILLSLGFYAIMTTTTQSFWLFRVSPTTFPFL 1187

  Fly  1014 VYNQFLSSLPIWLFTIICSVAC-LLPDFVIKVVNDMYRKVPLKSKPV 1059
            ..:..:.|.|..|..::.||:. ..|...::|:....:::..|.:.|
Human  1188 YADLSVMSSPSILLVVLLSVSINTFPVLALRVIFPALKELRAKEEKV 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	20/43 (47%)
		ATPase-Plipid	28..1051	CDD:273734	334/1136 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	34/109 (31%)
		Cation_ATPase	<489..568	CDD:289987	29/78 (37%)
		HAD_like	<758..807	CDD:304363	24/48 (50%)
		PhoLip_ATPase_C	804..1050	CDD:292829	59/255 (23%)
ATP8B3	XP_006722717.1	PhoLip_ATPase_N	108..184	CDD:292826	21/53 (40%)
		ATPase-Plipid	133..1220	CDD:273734	333/1133 (29%)
		Cation_ATPase	<593..669	CDD:289987	29/77 (38%)
		HAD_like	<931..975	CDD:304363	22/43 (51%)
		PhoLip_ATPase_C	975..1220	CDD:292829	58/250 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650