DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and AgaP_AGAP010026

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_319174.4	Gene:	AgaP_AGAP010026 / 1279454	VectorBaseID:	AGAP010026	Length:	1438	Species:	Anopheles gambiae

Alignment Length:	1240	Identity:	355/1240 - (28%)
Similarity:	580/1240 - (46%)	Gaps:	273/1240 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFF--VNETISPLVSLLPLLFVMIITALK 90
            |::.|||||..:|:|.|..|||.|....||:.|.::::|  :| .....::::|:|||:.:||:|
Mosquito   170 NKIRTTKYTLLSFVPKNLLEQFHRIANLYFIFIVLLNWFPQIN-AFGKEIAMIPVLFVLGVTAIK 233

  Fly    91 EGLEDYSRSKSDKLVNTARVTVIRNGKEEIINS---QFIVPGDLVVVRNDGDVPCDLVLLQSSSA 152
            :..||..|..|||.:|.:...|. ||:.|....   |.:..||||.:.|:..||.|::||:||..
Mosquito   234 DLFEDRRRKASDKRINNSTCRVY-NGESERYKKVLWQDVRVGDLVHLSNNECVPADILLLKSSDP 297

  Fly   153 DRKCFVNTANLDGETNLKTICVPTNYLLAGDHELQGK-------DCIVCEPSSADLYTFNGRLEL 210
            ...|:::|.:||||||||     ...::.|..|.|..       ..|..:..|..:|.|:|.:.
Mosquito   298 HGVCYIDTCDLDGETNLK-----RRQVVRGFVEKQHSFAPNKFTSRIEVDAPSTKIYRFHGAVI- 356

  Fly   211 RSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKY 275
                    ..:|:.:|::.::||||..|:|:|:...|..:|.|..||..||:.....|.:..|:.
Mosquito   357 --------HPSGERVPVSTESLLLRESRLKNTDYAEGIVVYAGHETKAMLNNSGPRYKRSRIEQQ 413

  Fly   276 INRFMVALIVGMIVVVVVLYL---IERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNY 337
            :|..::..::.:||:.:|..:   :..:.:...:|.:|::     .|..::....|.:|:::...
Mosquito   414 MNIDVIWCVIILIVLCIVGAVGCKLGTNNDTFRIPFLPFE-----INPDYEGLLAFWTFVIILQI 473

  Fly   338 MVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNL 402
            |:|:|.|:.||:.::..::.:||::.|||.::::.....|.|:.|||||:..:|||||||||:|.
Mosquito   474 MIPLSLYVTIELCKLMQVYHIHNNIELYDPDSNKRTECRAMNITEELGQIQYVFSDKTGTLTENR 538

  Fly   403 MKFVNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDADAAVL------------------------ 443
            |.|..|.:.|.:|.       ...|:|:.||.|:.|...:|
Mosquito   539 MIFRRCTIVGVDYN-------HPETEEEKELNKIGAPVPILQPNLNLLENFRGNSQSSLETAANQ 596

  Fly   444 ---FEALAVCHTVEVL--------------------------------------------QEVGD 461
               |..||:|:||.|.                                            ..:||
Mosquito   597 VEFFLVLAICNTVVVSATPHRDNMNASGVIEMNDSDTSVTLVRPALVDTDGGSLPLTACDPTIGD 661

  Fly   462 KTLESSESVS---------------EQSHLMS-------------------------------RN 480
            :....:||.|               :.:|:.|                               ::
Mosquito   662 RYARLTESRSITPSPPPNAPSSLPLKAAHVPSLSPISSSAETSPMSESPPMRIKSLTTPTAKVKS 726

  Fly   481 IVDR-----------------------------------YQASSPDEKALLEGCASLG--LVYEG 508
            :|.:                                   |:|.||||.||:....|..  ||...
Mosquito   727 LVAKLGNNRFASNNSSSGASKFHKSFSQGSSSPASSRPIYEAESPDELALVNAAFSYDCCLVNRS 791

  Fly   509 QENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIV-RDQSDTIWLYSKGAESAIFPR---CK 569
            ..:.::|:   |....::::.|.||.|.|.|:.|||:| |..:..:.||:|||:|:|.|.   |.
Mosquito   792 PNHVLVSV---PGEGVIEYEVLKVLPFDSARKCMSVVVRRTGTQDVVLYTKGADSSIIPNLVPCT 853

  Fly   570 ASP----LVEQTDAQITKYAQNGLRTMAVGRRML--TDDELFHFEELYRK---ANTQLSNRNELI 625
            ...    |.|||..|:..||:.|||.:.:.:|.|  ||     |.|.|.|   ....:.||...|
Mosquito   854 PGSEEYRLREQTQHQLNVYARQGLRVLVMAKRKLDATD-----FSEWYSKHEECELSMENRERKI 913

  Fly   626 ASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHI--- 687
            ...:..:|..|.|:|.|.:||.|||.|.||:.:|..||:.||||||||.|||.||..:.:..
Mosquito   914 RESFGMLERGLTLVGTTGIEDRLQEGVPETITSLLQAGIVIWVLTGDKAETAINIAYSAKLFNSQ 978

  Fly   688 ---------PRGSKQ---HFIINTTEPAELLARLDMIGD-----------DEPEVLIVDGTTITA 729
                     .|.|.:   :|.:|     |:..:|:..|.           |:...|:|||.|:|.
Mosquito   979 MDILKLTARSRDSAEASINFYLN-----EIEKQLNSNGGSSDADDAFDQLDKARALVVDGKTLTF 1038

  Fly   730 LLE---HTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHI 791
            :|:   :..:.|..|...|.:|||||.:||||:.:|.::|...:..|.|||||||||||||.|.:
Mosquito  1039 ILDLRSNLTKPFLRLTRYCSSVLCCRATPLQKAFLVKVVKEELRISTLAIGDGANDVSMIQMADV 1103

  Fly   792 GIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVY 856
            |:||.|:||.||...:|||||:|:||.:|.|||||:|..|||.:::::.|||......:..||.|
Mosquito  1104 GVGICGQEGMQAVMASDFSIAKFKMLEKLLLVHGHWNYDRLARMIIYFFYKNAAFVFLLFWYQFY 1168

  Fly   857 DLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFS-L 920
            ..:|...:.:.:||.::::::.:.....:.:.||...::.||::|:||:   |.|:.....:| .
Mosquito  1169 CGFSGAVMIDQVYLMIYNLLFTALPPLAIGVYDKKIIDDLLLAYPQLYQ---HGRRGKGYKWSTF 1230

  Fly   921 WI--LNGFVQCFIIFFFTYAMLNDANV-LFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMT 982
            ||  |:...|..:|||...|....::| |:..|.|.:.....|||:...:   .:|...:.|.::
Mosquito  1231 WIVMLDAVYQSLVIFFVAKAAYWGSDVDLWVFGTTITSSCLFTMLLHCAI---EIKSWTILHVLS 1292

  Fly   983 YRNFAMILASIAAFMLTTYLY-----NLYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVI 1042
                  |:.|:.:|....:.|     |.:.....|.|.:..:|::..:|.|::.||..|||.|..
Mosquito  1293 ------IVISLVSFYAFAFAYNSVCVNCFGLPSNYWVIHMSMSTIQYYLITLLTSVLALLPRFTY 1351

  Fly  1043 KVVND 1047
            :|:.:
Mosquito  1352 RVIKN 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	16/37 (43%)
		ATPase-Plipid	28..1051	CDD:273734	355/1240 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	40/107 (37%)
		Cation_ATPase	<489..568	CDD:289987	30/84 (36%)
		HAD_like	<758..807	CDD:304363	26/48 (54%)
		PhoLip_ATPase_C	804..1050	CDD:292829	71/253 (28%)
AgaP_AGAP010026	XP_319174.4	ATPase-Plipid	168..1360	CDD:273734	355/1240 (29%)
		PhoLip_ATPase_N	<168..218	CDD:292826	18/48 (38%)
		E1-E2_ATPase	219..>311	CDD:278548	35/92 (38%)
		Cation_ATPase	<770..853	CDD:289987	30/85 (35%)
		HAD_like	<1070..1116	CDD:304363	25/45 (56%)
		PhoLip_ATPase_C	1116..1360	CDD:292829	71/253 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820