DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and AgaP_AGAP008184

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_317283.4	Gene:	AgaP_AGAP008184 / 1277786	VectorBaseID:	AGAP008184	Length:	1066	Species:	Anopheles gambiae

Alignment Length:	1109	Identity:	327/1109 - (29%)
Similarity:	525/1109 - (47%)	Gaps:	131/1109 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KSADPLRIQIGGIESRQQKPLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETI 71
            |...|..|.||. ...::.|.|.:...||.:||||||..:||||..:..||||:.:..|.....|
Mosquito    14 KELKPRTIYIGR-PLTEKFPPNEIRNQKYNFFTFLPLVLFEQFRFFLNLYFLIMAVSQFIPEIRI 77

  Fly    72 SPLVSLL-PLLFVMIITALKEGLEDYSRSKSDKLVNTARVT--VIRNGKEEIINSQFIVPGDLVV 133
            ..|.:.. ||.||:.:|..:|.::|..|.|.|:.||:.:..  |..:...|.::|..:..||:::
Mosquito    78 GYLYTYWGPLGFVLAVTICREAVDDLRRHKRDREVNSQKYKRFVSADKPPESVSSSKLRVGDIIM 142

  Fly   134 VRNDGDVPCDLVLLQSSSADRKCFVNTANLDGETNLK-TICVPTNYLLAGDHELQGKDC-IVCEP 196
            |..|..||.||:||::|......||.|..|||||:.| .:.||....||...||...:. :..|.
Mosquito   143 VEKDERVPADLILLRTSDKSGAVFVRTDMLDGETDWKLRLAVPATQKLASHGELLTVNASLYVEK 207

  Fly   197 SSADLYTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLN 261
            ...|::||.|......|.:..|        |.::|.|.... |.::...||..||||..|:..:|
Mosquito   208 PQRDIHTFIGTYSKHGGTEDEG--------LNVENTLWANT-VVASGTAVGIVIYTGSETRSVMN 263

  Fly   262 SRYTGNKSASSEKYIN---RFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQ 323
            :....:|....:..||   :.:...::|:...::.|                     ..||..|
Mosquito   264 NSQPRSKVGLLDLEINNLTKVLFCAVIGLSFAMMCL---------------------KGFNGPW- 306

  Fly   324 IFEDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVN 388
             :.....|:|||:|::|||..:|:::.:.|....:.||    ||  .:...|.::.:.||||:::
Mosquito   307 -YRYMFRFVLLFSYIIPISLRVNLDMGKAFYSWQIQND----DE--IKGTVVRSTTIPEELGRMS 364

  Fly   389 ILFSDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDADAAV----------- 442
            .|.:|||||||:|.|.|...:|....|......:||......:......|||:.
Mosquito   365 YLLTDKTGTLTQNEMIFKKIHVGTAAYGRDTFPMVSAAIQSVYGTLSAPADASPEDHGSEYQPRL 429

  Fly   443 -------LFE---ALAVCHTVEVLQE-------------VGDKTLESSESVS------EQSHLMS 478
                   ::|   |||:||.|..:.|             ..|:....:.|:|      |.|....
Mosquito   430 RKPDGWRIWESVKALALCHNVTPVYESNNGNGGSGSISSTSDRRQSPARSISVESQAGEPSTSKP 494

  Fly   479 RNIVDRYQASSPDEKALLEGCASLGLVYEGQE--------NDVLSICRYPSAEK-----VQFKRL 530
            ......||||||||.||::...|:||....::        .|.....|..|..:     ..::.|
Mosquito   495 ATTEKTYQASSPDEIALVKWTESVGLTLVQRDLNHMTLQIRDATHEARGTSMNENASINTTYQIL 559

  Fly   531 HVLEFSSERQRMSVIVRD-QSDTIWLYSKGAESAIFPRCKASPLVEQTD---AQITKYAQNGLRT 591
            ....|:||.:||.:|||: ....|..|.|||:..:      |.:|:..|   .:....|:.||||
Mosquito   560 QTFPFTSENKRMGIIVRELNGGEITFYLKGADVVM------SGIVQYNDWLAEESGNMAREGLRT 618

  Fly   592 MAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETL 656
            :.|.:::|::::...|...|..|...:::|...:|:..|::|.|::||..|.:||.||:.|..||
Mosquito   619 LVVAKKVLSEEQYNDFVMRYNAAKVSVTDRVAKVAAVIESLEREMELLCLTGVEDRLQDRVRPTL 683

  Fly   657 EALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDMIGDDEPEVLI 721
            |.|:.||:|||:|||||:|||..|..:...:.|....|.:.:.....:....|:.....:...|:
Mosquito   684 ELLRNAGIKIWMLTGDKLETATCIAKSSHLVGRNQSIHVLKSVLTRTDAHLELNQFRRKQDCALV 748

  Fly   722 VDGTTITALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMI 786
            |.|.::...|::...:|.:||..|.||:|||.||.||:::|:||::..|..|.|:|||.||||||
Mosquito   749 VSGESLEVCLQYYQPEFMELATACPAVVCCRCSPTQKAQVVSLIQKYSKKRTCAVGDGGNDVSMI 813

  Fly   787 QEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMA 851
            |:|..||||.|||||||:...||||.:|..:.||.:|||..:.:|.|.|..|..::.:||:...|
Mosquito   814 QQADAGIGIEGREGKQASLAGDFSIPQFSHIARLLIVHGRRSYKRSAALSQFVIHRGLIISTMQA 878

  Fly   852 LYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMG 916
            ::......|:..:|....:..:..:|..|....| :.|:|.|....:::|||||.|:..|..|..
Mosquito   879 VFSAVFYLSSVALYQGFLMVGYATLYTMFPVFSL-VLDQDISANIAITYPELYKELSKGRSLSYK 942

  Fly   917 VFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYM 981
            .|.:|:|....|..:|.:....:..|..:....      .:|..:::|        :|::||  :
Mosquito   943 TFFMWVLISIYQGGVIMYGALILFEDEFIHIVA------ISFSALILT--------ELIMVA--L 991

  Fly   982 TYRNFAMILASIAAFMLTTYLYNLYTSGELYDVYNQFLSSLP-IWLFTIICSVACLLPDFVIKVV 1045
            |.|.:..::.....|.|..|:.:|....|.:|.  :|:.|.. :|...:|..|:| ||.:::|.:
Mosquito   992 TIRTWHKLMVIAELFSLVLYIVSLAVLHEYFDW--EFIWSWDFLWKVLVITLVSC-LPLYILKFL 1053

  Fly  1046 NDMY 1049
            ...:
Mosquito  1054 RKKF 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/45 (40%)
		ATPase-Plipid	28..1051	CDD:273734	321/1088 (30%)
		E1-E2_ATPase	84..>189	CDD:278548	37/107 (35%)
		Cation_ATPase	<489..568	CDD:289987	26/92 (28%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	61/247 (25%)
AgaP_AGAP008184	XP_317283.4	PhoLip_ATPase_N	20..82	CDD:292826	24/62 (39%)
		ATPase-Plipid	31..1065	CDD:273734	322/1091 (30%)
		E1-E2_ATPase	128..327	CDD:278548	63/230 (27%)
		Cation_ATPase	<505..593	CDD:289987	26/87 (30%)
		HAD_like	<787..826	CDD:304363	22/38 (58%)
		PhoLip_ATPase_C	831..1059	CDD:292829	61/247 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920