DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp10a

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_033858.2	Gene:	Atp10a / 11982	MGIID:	1330809	Length:	1508	Species:	Mus musculus

Alignment Length:	1269	Identity:	371/1269 - (29%)
Similarity:	574/1269 - (45%)	Gaps:	276/1269 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFF--VNETISPLVSLLPLLFVMIITALK 90
            ||:.|||||..:|||.|.:|||.|....||:.|.:::|.  || ...|.::|.|:||::.:||:|
Mouse    66 NRLKTTKYTLLSFLPKNLFEQFHRLANVYFVFIALLNFVPAVN-AFQPGLALAPVLFILAVTAIK 129

  Fly    91 EGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQF--IVPGDLVVVRNDGDVPCDLVLLQSSSAD 153
            :..|||||.:||..:|.....|....:::.:|..:  |..||.|.:..:..:|.|::||.||..|
Mouse   130 DLWEDYSRHRSDHEINHLGCLVFSREEKKYVNRYWKEIRVGDFVRLCCNEIIPADILLLSSSDPD 194

  Fly   154 RKCFVNTANLDGETNLKTICVPTNY--LLAGDHELQGKDCIVCEPSSADLYTFNGRLELRSGNDG 216
            ..|.:.|||||||||||...|...:  |::..:.|.....|.||..:.||..|.|.: :.|..:.
Mouse   195 GLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGYI-MHSNGEK 258

  Fly   217 AGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMV 281
            ||        |..:||||||..:::||.|.|..||.|..||..||:.....|.:..|:.:|..::
Mouse   259 AG--------LHKENLLLRGCTIRNTEAVAGIVIYAGHETKALLNNSGPRYKRSQLERQMNCDVL 315

  Fly   282 ALIVGMIVVVVVLY-------LIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMV 339
            ..:  :::|.:.|:       .:.|::|.|.:..:| :...::.:.|......|.:.:::...::
Mouse   316 WCV--LLLVCISLFSAVGHGLWVRRYQEKKALFDVP-ESDGSSLSPATAAVYSFFTMIIVLQVLI 377

  Fly   340 PISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMK 404
            |||.|::||:.::..::|::.|:.|||||||...:..|.|:.|:|||:..:|||||||||:|.|.
Mouse   378 PISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNITEDLGQIKYIFSDKTGTLTENKMV 442

  Fly   405 FVNCYVPGTNY---------------------------------------QLQNTH--------- 421
            |..|.|.|..|                                       .:..||
Mouse   443 FRRCTVSGIEYSHDANAQRLARYQEADSEEEEVVSKVGTISHRGSTGSHQSIWMTHKTQSIKSHR 507

  Fly   422 ------------LVSEGT------------DEKFELEKLD-----------------------AD 439
                        ::|:.|            |.|. |||:.                       :|
Mouse   508 RTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKL-LEKVSECDRFLAIARHQEHPLAHLSPELSD 571

  Fly   440 AAVLFEALAVCHTVEV--------------------------------------LQEVGD-KTLE 465
            ....|.||.:|:||.|                                      ...:|: .|.:
Mouse   572 VFDFFIALTICNTVVVTSPDQPRQKVRVRFELKSPVKTIEDFLRRFTPSRLASGCSSIGNLSTSK 636

  Fly   466 SSE--------SVSEQSHLM-----------------------------SRNIVD---------- 483
            ||.        |:|:.|.|:                             |....|
Mouse   637 SSHKSGSAFLPSLSQDSMLLGLEEKLGQTAPSIASNGYASQAGQEESWASECTTDQKCPGEQREQ 701

  Fly   484 -----RYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMS 543
                 ||:|.||||.||:....:.......:.:|.:|: ..|...::.|:.||.|.|.|.|:|||
Mouse   702 QEGELRYEAESPDEAALVYAARAYNCALVDRLHDQVSV-ELPHLGRLTFELLHTLGFDSIRKRMS 765

  Fly   544 VIVRDQ-SDTIWLYSKGAESAIFP---RCKA--------SPLVEQTDAQITKYAQNGLRTMAVGR 596
            |::|.. :|.|.:|:|||:|.:..   .|.:        ..:..:|...:..||..||||:.:.:
Mouse   766 VVIRHPLTDEINVYTKGADSVVMDLLLPCSSDDARGRHQKKIRSKTQNYLNLYAVEGLRTLCIAK 830

  Fly   597 RMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEALQA 661
            |:|:.:|...:.:.:.:|...:.:|.||:......:|..|.|||||.:||.|||.|.||:..|:.
Mouse   831 RVLSKEEYACWLQSHIEAEASVESREELLFQSAVRLETNLHLLGATGIEDRLQEGVPETIAKLRQ 895

  Fly   662 AGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDM--------------- 711
            |||:||||||||.|||.||..||:.:..| ::...:|........|.||.
Mouse   896 AGLQIWVLTGDKQETAINIAYACKLLDHG-EEVITLNADSQEACAALLDQCLSYVQSRNPRSTLQ 959

  Fly   712 -------IG----------DDEPE-VLIVDGTTITALLEHT-PRQFADLALRCRAVLCCRLSPLQ 757
                   :|          |..|. .|::||.::...||.: ..:|..||.:||:|||||.:|||
Mouse   960 NSESNLSVGFSFNPVSTSTDASPSPSLVIDGRSLAYALEKSLEDKFLFLAKQCRSVLCCRSTPLQ 1024

  Fly   758 KSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFL 822
            ||.:|.|::.:.|.:|.|||||||||||||.|.:|:||:|:||.||...:||::.||..|.||.:
Mouse  1025 KSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPRFRYLERLLI 1089

  Fly   823 VHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAI 887
            ||||:...|||.:||::.|||.:..|.:..:|.|..:||:.:.:..||..|::::.|....|..:
Mouse  1090 VHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFYCGFSASAMIDQWYLIFFNLLFSSLPQLVTGV 1154

  Fly   888 CDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANV-LFNGGQ 951
            .|||...:.||..|:|||...:..:.....|.|.:::...|..:.||..|....|::| :|
Mouse  1155 LDKDVPADMLLREPQLYKSGQNMEEYRPRAFWLNMVDAAFQSLVCFFIPYLAYYDSDVDVF---- 1215

  Fly   952 TASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYN-----LYTSGEL 1011
                 |:||.:..|.:....|.|.:.....|:.|:.....|...|.....:||     .|.....
Mouse  1216 -----TWGTPVTAIALFTFLLHLGIETKTWTWLNWLACGFSTFLFFSVALIYNTSCATCYPPSNP 1275

  Fly  1012 YDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVV 1045
            |......|.....:|..:|..:|.|||....|.:
Mouse  1276 YWTMQTLLGDPLFYLTCLIAPIAALLPRLFFKAL 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/37 (49%)
		ATPase-Plipid	28..1051	CDD:273734	371/1269 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	39/108 (36%)
		Cation_ATPase	<489..568	CDD:289987	28/82 (34%)
		HAD_like	<758..807	CDD:304363	28/48 (58%)
		PhoLip_ATPase_C	804..1050	CDD:292829	69/248 (28%)
Atp10a	NP_033858.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		P-type_ATPase_APLT_Dnf-like	65..1203	CDD:319770	345/1152 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..705		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1334..1354
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1407..1436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1481..1508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820