DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp8a1

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_017176112.1	Gene:	Atp8a1 / 11980	MGIID:	1330848	Length:	1177	Species:	Mus musculus

Alignment Length:	1102	Identity:	387/1102 - (35%)
Similarity:	581/1102 - (52%)	Gaps:	133/1102 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISP---LVSLLPLLFVMIITAL 89
            |.|:|.||...||||...|.|||||...:||.|.::....:  :||   ..:|:||||::.:.|:
Mouse    65 NHVSTAKYNVITFLPRFLYSQFRRAANSFFLFIALLQQIPD--VSPTGRYTTLVPLLFILAVAAI 127

  Fly    90 KEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADR 154
            ||.:||..|.|:|..||..:..|:|||..||::.:.:..|::|.|.|...:|.||:.|.||....
Mouse   128 KEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLLSLSSSEPQA 192

  Fly   155 KCFVNTANLDGETNLKTICVPTNYLLAGDHELQGKDCIV-------CEPSSADLYTFNGRLELRS 212
            .|::.|:|||||||||     ....|....:::..|.::       ||..:..||.|.|.:.|
Mouse   193 MCYIETSNLDGETNLK-----IRQGLPATSDIKDIDSLMRISGRIECESPNRHLYDFVGNIRL-- 250

  Fly   213 GNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYIN 277
              ||.|:     :||..|.:||||.::::|:.|.|..:|||..|||..||.....|.::.|:..|
Mouse   251 --DGHGT-----VPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITN 308

  Fly   278 ---RFMVALIVGMIVVVVVLYLI--ERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNY 337
               ..:..:::.|.:|..|...|  .||........:.| |..:||..      :||:|::|||.
Mouse   309 VQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLHLHY-GGASNFGL------NFLTFIILFNN 366

  Fly   338 MVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNL 402
            ::|||..:.:||.:....:|::.||.::.|.||.......||||||||||..:|||||||||.|:
Mouse   367 LIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNV 431

  Fly   403 MKFVNCYVPGTNY--------------QLQNTHLVSEGT-DEKFELEKLDAD---AAVLFEAL-- 447
            |:|..|.:.|..|              :.|::....|.| ::...|:.|..:   |.::.|.|
Mouse   432 MQFKKCTIAGVAYGHVPEPEDYGCSPDEWQSSQFGDEKTFNDPSLLDNLQNNHPTAPIICEFLTM 496

  Fly   448 -AVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQEN 511
             |||||. |.:..|||.:                    |||:||||.||:.....|..|:.|:..
Mouse   497 MAVCHTA-VPEREGDKII--------------------YQAASPDEGALVRAAKQLNFVFTGRTP 540

  Fly   512 DVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPR-CKASPLVE 575
            |.:.|......|:  ::.|:||||:|.|:||||:||..|..:.||.|||::.|:.| .:.|...|
Mouse   541 DSVIIDSLGQEER--YELLNVLEFTSARKRMSVVVRTPSGKLRLYCKGADTVIYERLAETSKYKE 603

  Fly   576 QTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLG 640
            .|...:.::|..||||:......:::.:...:..:|.:|:|.:.||...:...||.:|..|.|||
Mouse   604 ITLKHLEQFATEGLRTLCFAVAEISESDFEEWRAVYHRASTSVQNRLLKLEESYELIEKNLQLLG 668

  Fly   641 ATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTE---P 702
            |||:||.||:.|.||:|.|..|.:|||:|||||.|||.|||.:||.:.|.... .:||...   .
Mouse   669 ATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCRLLKRNMGM-IVINEGSLDGT 732

  Fly   703 AELLAR-LDMIGD----DEPEVLIVDGTTITALLEHTPRQ-FADLALRCRAVLCCRLSPLQKSEI 761
            .|.|:| ...:||    :....||:||.|:...|....|| |.||||.|:||:|||:|||||||:
Mouse   733 RETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEV 797

  Fly   762 VTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGH 826
            |.::|::.|.||.|||||||||||||.||:|:||:|.||.|||..:|:|||:|:.|:.|.:|||.
Mouse   798 VEMVKKQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMVHGA 862

  Fly   827 YNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYL---W---LFDIVYISFSFTVL 885
            :|..|::..:|:..||||:      ||.:...::..|.::...|   |   |:::::.:.....|
Mouse   863 WNYNRVSKCILYCFYKNIV------LYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTL 921

  Fly   886 AICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGG 950
            .|.::...:|.:|.:|||||...:....:..||.:..|||.....|:|:|....|....| |..|
Mouse   922 GIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTV-FGNG 985

  Fly   951 QTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYT-------- 1007
            :|:.:...|..:.|.:||...||..|...|.|:.:...|..|||.:::   .:.:|:
Mouse   986 KTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVV---FFGIYSSLWPAVPM 1047

  Fly  1008 ----SGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVN--------DMYRKVPLKSK 1057
                |||...::    ||...|:..:...||.||.|.:.||:.        |..:::..||:
Mouse  1048 APDMSGEAAMLF----SSGVFWVGLLSIPVASLLLDVLYKVIKRTAFKTLVDEVQELEAKSQ 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/37 (49%)
		ATPase-Plipid	28..1051	CDD:273734	385/1094 (35%)
		E1-E2_ATPase	84..>189	CDD:278548	38/104 (37%)
		Cation_ATPase	<489..568	CDD:289987	33/79 (42%)
		HAD_like	<758..807	CDD:304363	32/48 (67%)
		PhoLip_ATPase_C	804..1050	CDD:292829	74/271 (27%)
Atp8a1	XP_017176112.1	ATPase-Plipid	62..1099	CDD:273734	385/1094 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7147
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720