DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and atp8a2

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_012813389.2	Gene:	atp8a2 / 101730757	XenbaseID:	XB-GENE-6036032	Length:	1197	Species:	Xenopus tropicalis

Alignment Length:	1095	Identity:	365/1095 - (33%)
Similarity:	563/1095 - (51%)	Gaps:	131/1095 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISP---LVSLLPLLFVMIITAL 89
            |.|:|.||:..||||...|||.|||...:||.|.::....:  :||   ..:|:||:|::.:..:
Frog    81 NTVSTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPD--VSPTGRYTTLVPLIFILTVAGI 143

  Fly    90 KEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADR 154
            ||.:|||.|.|:|..||..:..|::.|..:.:..:.:..||:|.|.|...:|.|:::|.||....
Frog   144 KEIIEDYKRHKADNTVNKKKTIVLKGGTWQNMVWREVAVGDIVKVTNGQHLPADMIILSSSEPQA 208

  Fly   155 KCFVNTANLDGETNLKTI--CVPTNYLLAGDHELQGKDCIVCEPSSADLYTFNGRLELRSGNDGA 217
            .|::.|:|||||||||..  ...|:.||:.:..::....|.||..:..||.|.|.|.|.:.|
Frog   209 MCYIETSNLDGETNLKIRQGLPATSNLLSEEDLVKMTGRIECEGPNRHLYDFIGNLRLGTNN--- 270

  Fly   218 GSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMVA 282
                  .:|:..:.:||||.::::|:.|:|..:|||..|||..||.....|.::.||..| ..:.
Frog   271 ------PVPVGPEQILLRGAQIRNTQWVIGIVVYTGHDTKLMQNSTKAPLKRSNVEKVTN-VQIL 328

  Fly   283 LIVGMIVVVVVLYLIERHKEAKIVPTMPYQGP----------PTNFNSAWQIFEDFLSFLLLFNY 337
            ::.|:::|:.::..:     ..::....|:|.          .|||.      .:.|:|::|:|.
Frog   329 VLFGILLVMALVSSV-----GALLWNWKYEGTNWYLGDIDAVSTNFG------YNLLTFIILYNN 382

  Fly   338 MVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNL 402
            ::|||..:.:||.:.....|::.|..:|..|||.|.....||||||||||..||||||||||.|:
Frog   383 LIPISLLVTLEVVKFTQALFINWDRDMYYSETDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNV 447

  Fly   403 MKFVNCYVPGTNYQLQNTHLVS---EGTDEKFE-----LEKLDADAAVLFE-------------- 445
            |.|..|.:.|..|    .|...   |.:.|.|.     .|..|.|...||:
Frog   448 MHFKKCSIGGITY----GHFPEFERERSSEDFSQLPTTSESCDFDDPKLFQNIENDSPTGDTIKE 508

  Fly   446 ---ALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYE 507
               .||||||  |:.|..:.|:                   .||||||||.||::|...||..:.
Frog   509 FLTLLAVCHT--VVPEKDEDTI-------------------IYQASSPDEGALVKGARKLGYTFT 552

  Fly   508 GQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPR-CKAS 571
            |:..|  |:......::..|:.|:||||||.|:|||||||..|..:.||.|||::.||.| .:.|
Frog   553 GRTPD--SVIIDAMGKEQSFELLNVLEFSSNRKRMSVIVRTPSGNLRLYCKGADNVIFERLSRES 615

  Fly   572 PLVEQTDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENEL 636
            ..:|||...:.::|..||||:.:....|.|.|...:..::.:|:..:.:|.:.:..|||.:|.:|
Frog   616 KYMEQTLNHLEQFASEGLRTLCLAYCDLQDSEYEAWLNVHSEASVVIKDRAQKLEECYEIIEKDL 680

  Fly   637 DLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTE 701
            .||||||:||.||..|.||:..|..|.:|||||||||.|||.|||.:||.:.: :....::|...
Frog   681 MLLGATAIEDRLQGGVPETIATLMKAEIKIWVLTGDKQETAVNIGYSCRLVSQ-TMSLIVVNEDS 744

  Fly   702 PAELLARL--------DMIGDDEPEVLIVDGTTITALLEHTPRQ-FADLALRCRAVLCCRLSPLQ 757
            .....:.|        |.:|.:....||:||.|:...|....|| |.||||.|:||:|||:||||
Frog   745 LDATRSTLTNHCTNLGDGLGKENDLALIIDGQTLKYALSFEVRQSFLDLALSCKAVICCRVSPLQ 809

  Fly   758 KSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFL 822
            |||||.::|:....||.|||||||||.|||.||:|:||:|.||.||...:|::||:|..|.:|.|
Frog   810 KSEIVDMVKKHVNAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFCYLEKLLL 874

  Fly   823 VHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAI 887
            |||.::..|:...:|:..|||:::......:.|.:.:|...::....:.|:::::.:.....|.|
Frog   875 VHGAWSYNRVTKCILYCFYKNVVLYIIELWFAVVNGFSGQVLFERWCIGLYNVIFTALPPFTLGI 939

  Fly   888 CDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQT 952
            |::..|::::|..|:|||...:....:..||....:|..:...|:|:|...|| :.:.:|..||.
Frog   940 CERSCSQDSMLRFPQLYKITQNADGFNTRVFWGHCINALIHSIILFWFPLKML-EHDAVFTNGQV 1003

  Fly   953 ASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYTSGELYDVYNQ 1017
            ..:...|.::.|.:|:...||..|.....|..:...:..|:..:::            .:..|:.
Frog  1004 TDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLMWLV------------FFGAYSA 1056

  Fly  1018 FLSSLPI-----------------WLFTIICSVACLLPDFVIKVVNDMYRKVPLK 1055
            ...::||                 ||..::...||||.|...:.....|.|..|:
Frog  1057 IWPTIPIAPDMLGQAGMVLTSGYFWLGLLLVPTACLLRDVTWRAAKHTYHKTLLE 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/37 (49%)
		ATPase-Plipid	28..1051	CDD:273734	363/1089 (33%)
		E1-E2_ATPase	84..>189	CDD:278548	36/106 (34%)
		Cation_ATPase	<489..568	CDD:289987	37/79 (47%)
		HAD_like	<758..807	CDD:304363	30/48 (63%)
		PhoLip_ATPase_C	804..1050	CDD:292829	56/262 (21%)
atp8a2	XP_012813389.2	ATPase-Plipid	78..1115	CDD:273734	365/1095 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010