DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and ATP9A

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_006036.1	Gene:	ATP9A / 10079	HGNCID:	13540	Length:	1047	Species:	Homo sapiens

Alignment Length:	1074	Identity:	319/1074 - (29%)
Similarity:	530/1074 - (49%)	Gaps:	117/1074 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ADPLRIQIGGIESRQQK-PLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETIS 72
            |.|..:.:|..|.|.|: |.|.:...||.:|||||...:.||:.....|||::....|.....:.
Human    36 ARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLG 100

  Fly    73 PLVSL-LPLLFVMIITALKEGLEDYSRSKSDKLVN-------TARVTVIRNGKEEIINSQFIVPG 129
            .|.:. :||.||:.:|.::|.:|:......||.||       |||.||       .:.|..|..|
Human   101 ALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTV-------KVKSSNIQVG 158

  Fly   130 DLVVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGETNLK-------TICVPTNYLLAGDHELQ 187
            ||::|..:..||.|::.|::|..:..||:.|..|||||:.|       |..:||    |.| .||
Human   159 DLIIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPT----AAD-LLQ 218

  Fly   188 GKDCIVCEPSSADLYTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYT 252
            .:..:..|..:.|::.|.|.. .|..:|...|.:     |:|:|.|..|. |.::..|||..:||
Human   219 IRSYVYAEEPNIDIHNFVGTF-TREDSDPPISES-----LSIENTLWAGT-VVASGTVVGVVLYT 276

  Fly   253 GMHTKLQLNSRYTGNKSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTN 317
            |...:..:|:....:|....:..:| .:..::.|.:|||.::.:..:|
Human   277 GRELRSVMNTSNPRSKIGLFDLEVN-CLTKILFGALVVVSLVMVALQH----------------- 323

  Fly   318 FNSAWQIFEDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNE 382
            |...|.:  ..:.|||||:.::|||..:|:::.:|.....:..|..:      ....|.:|.:.|
Human   324 FAGRWYL--QIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKI------PGTVVRSSTIPE 380

  Fly   383 ELGQVNILFSDKTGTLTKNLMKFVNCYVPGTNYQLQN-----THLVSEGTDEKFE---------- 432
            :||:::.|.:|||||||:|.|.|...::....|.|.:     :|:.|..|.:..:
Human   381 QLGRISYLLTDKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLT 445

  Fly   433 ---LEKLDADAAVLFEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKA 494
               ...:.:......:|:|:||.|..:.|....|   .::.:|:.:..|..:   ||||||||.|
Human   446 TKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVT---DQAEAEKQYEDSCRV---YQASSPDEVA 504

  Fly   495 LLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQS-DTIWLYSK 558
            |::...|:||...|::...:.: |.|..:.:.|..|.:..|:.|.:||.:||||:| ..|..|.|
Human   505 LVQWTESVGLTLVGRDQSSMQL-RTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMK 568

  Fly   559 GAESAIFPRCKASPLVEQTD---AQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSN 620
            ||:..:      :.:|:..|   .:....|:.|||.:.|.::.|.:::...||..|.:|...:.:
Human   569 GADVVM------AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHD 627

  Fly   621 RNELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACR 685
            |:..:|:..|::|.|::||..|.:||.||..|..|||.|:.||:|:|:|||||:|||........
Human   628 RSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAH 692

  Fly   686 HIPRGSKQHFIINTTEPAELLARLDMIGDDEPEVLIVDGTTITALLEHTPRQFADLALRCRAVLC 750
            .:.|....|.....|...|....|:.........|::.|.::...|::...:|.:||.:|.||:|
Human   693 LVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELACQCPAVVC 757

  Fly   751 CRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFE 815
            ||.:|.||::||.|::.|...:|.|:|||.||||||||:..|:|:.|:|||||:..|||||.:|:
Human   758 CRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFK 822

  Fly   816 MLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISF 880
            .|.||.:|||..:.:|.|.|..|..::::.|:...|::.....:::..:|....:..:..:|..|
Human   823 HLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMF 887

  Fly   881 SFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANV 945
            ....| :.|||...|..:.:|||||.|...|..|...|.:|:|....|...|.:       .|.:
Human   888 PVFSL-VLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMY-------GALL 944

  Fly   946 LFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYTSGE 1010
            ||.    :.|.....:..|.:::.   :||:||  :|.:.:..::.......|..|:.:|....|
Human   945 LFE----SEFVHIVAISFTSLILT---ELLMVA--LTIQTWHWLMTVAELLSLACYIASLVFLHE 1000

  Fly  1011 LYDVYNQFLSSLP-IWLFTIICSVACLLPDFVIK 1043
            ..|||  |:::|. :|..::|..|:| ||.:|:|
Human  1001 FIDVY--FIATLSFLWKVSVITLVSC-LPLYVLK 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	17/46 (37%)
		ATPase-Plipid	28..1051	CDD:273734	312/1054 (30%)
		E1-E2_ATPase	84..>189	CDD:278548	39/118 (33%)
		Cation_ATPase	<489..568	CDD:289987	28/79 (35%)
		HAD_like	<758..807	CDD:304363	26/48 (54%)
		PhoLip_ATPase_C	804..1050	CDD:292829	66/241 (27%)
ATP9A	NP_006036.1	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	290/984 (29%)
ATP9A	NP_006036.1	Cation_ATPase	464..571	CDD:404183	39/113 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850