DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and atp11c

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_004917005.2	Gene:	atp11c / 100498300	XenbaseID:	XB-GENE-976439	Length:	1149	Species:	Xenopus tropicalis

Alignment Length:	1096	Identity:	398/1096 - (36%)
Similarity:	604/1096 - (55%)	Gaps:	126/1096 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISPLVSLLPLLFVMIITALKEG 92
            ||:.::|||.:.|:|.|.:|||||...||||||.::...|:...||:.|.|||.||:.:||:|:|
Frog    43 NRIVSSKYTIWNFIPKNLFEQFRRIANFYFLIIFLIQAIVDTPTSPVTSGLPLFFVITVTAIKQG 107

  Fly    93 LEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRKCF 157
            .||:.|.::|..||.:.|.||...|.....|:.|..||:|.||::...|||||:|.:|..|..|.
Frog   108 YEDWLRHRADHEVNKSTVYVIEGSKCVKKESEKIKVGDIVEVRDNETFPCDLVMLSTSCRDGTCT 172

  Fly   158 VNTANLDGETNLKTI-CVPTNYLLAGDHELQG-KDCIVCEPSSADLYTFNGRLELRSGNDGAGSS 220
            |.||:||||:|.||. .||...:||...:|.. ...|.||....|||.|:||:::.:..|....|
Frog   173 VTTASLDGESNFKTYHAVPETAILATYEDLNAFSATIECEQPQPDLYKFHGRIDVNTNQDVKARS 237

  Fly   221 AGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMVALIV 285
            .|.      :||||:|..:|:|:::.|.|:||||.||:.||.:....|.::.||.||.|   |||
Frog   238 LGP------ENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAF---LIV 293

  Fly   286 GMIVVVVVLYLIERHKEAKIVPTMPY--QGPPTNFNSAW---------------QIFEDFLSFLL 333
            .:.::|         .:|.|..::.|  |..|.| :..|               ::|.|||||::
Frog   294 YLCILV---------SKATICTSLKYLWQSNPAN-DEPWYNEKTRKEKEAFKILKMFTDFLSFMV 348

  Fly   334 LFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTL 398
            |||:::|:|.|:.:|:.:..|..|:..|:.::|||.::...||.|:||||||||..:|:||||||
Frog   349 LFNFIIPVSMYVTVEMQKFLGSFFIAWDMEMFDEEINEGALVNTSDLNEELGQVEYVFTDKTGTL 413

  Fly   399 TKNLMKFVNCYVPGTNYQLQNTHLVSEG---TDEKFELEKLDADAAVLF-EALAVCHTVEVLQE- 458
            |:|.|:|:.|.:.|..|  .||..: :|   ||......|...|...|| .||.:||||::.:|
Frog   414 TENKMEFIECCIDGHKY--ANTDAM-DGLSLTDGLAYFGKASQDLEELFLRALCLCHTVQMKEEC 475

  Fly   459 -VGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSA 522
             ....:..|:::.:             |.:|||||.||:.|....|..|.|.||:|:|: .....
Frog   476 HTDGPSFSSTDNCA-------------YISSSPDEIALVTGAKRYGFTYMGTENNVMSV-ENQKN 526

  Fly   523 EKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKASPLVEQTDAQITKYAQN 587
            |..:::.||||.|...|:||||:|:.::..|:|:.|||:|::|||. |...|::....:.|.|.:
Frog   527 EIERYQLLHVLNFDPVRRRMSVLVKAKTGKIFLFCKGADSSMFPRV-ARDQVQRIKVHVEKNALD 590

  Fly   588 GLRTMAVGRRMLTDDELFHFEELYRKANTQ-------LSNRNELIASCYETVENELDLLGATALE 645
            |.||:.|..:.::       :|||...|.|       |.:|.|.:|..|:.:|.::.||||||:|
Frog   591 GYRTLCVAFKEVS-------QELYENINKQLEEAKLALQDREERLAKVYDDIEADMHLLGATAVE 648

  Fly   646 DALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLD 710
            |.|||...||:|||.|||:|:|||||||:|||.:...|||...  |....:..||:..|...|.:
Frog   649 DRLQEQAAETIEALHAAGMKVWVLTGDKLETAKSTCYACRLFQ--SNTELLELTTKDLEEYERKE 711

  Fly   711 ------------MIGDDEPEV---------------LIVDGTTITALL------EHTPRQFADLA 742
                        .:..:.|::               ||:||.|::.:|      .|....|..:.
Frog   712 DRLQELLMEYHRKLVQEAPKLKGGANRSWTGNQDHGLIIDGATLSLILNSNCSSSHYKNIFLQIC 776

  Fly   743 LRCRAVLCCRLSPLQKSEIVTLIKRRK-KYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARC 806
            .:|.||||||::||||::||.::|..| ..||.::||||||||||.|||:||||.|:||:||||.
Frog   777 QKCSAVLCCRMAPLQKAQIVKMVKNTKGSPITLSVGDGANDVSMILEAHVGIGIKGKEGRQAARS 841

  Fly   807 ADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLW 871
            :|:::.:|:.||:|.|.|||....|:|.||.::.|||:.......|||.:..:|...:|::.||.
Frog   842 SDYAVPKFKHLRKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLT 906

  Fly   872 LFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFT 936
            :::|.:.|......::.::..:.|.|.|:|:||..::.|.....|.|..|.|.|..:..:.||..
Frog   907 MYNICFTSMPILAYSLLEQRINIEILSSNPKLYMRISDNAMLQWGPFLYWTLLGAFEGLVFFFGV 971

  Fly   937 YAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTY 1001
            |.:..:. .|...||.....:||||:.||:|....|||.|...|.|:.|...|..|:|.::
Frog   972 YFLFQNP-ALEGNGQVYGNWSFGTMVFTILVFTVTLKLALDTRYWTWMNHLAIWGSLAFYV---- 1031

  Fly  1002 LYNLYTSG---------ELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVNDM 1048
            :::|:..|         .:|.|::..|:|:.|||..|:.....|.|:.|:.:|.::
Frog  1032 IFSLFWGGIIWPFLKQQRMYFVFSHILTSVSIWLGIILLIFVSLYPEIVLILVKNL 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	19/37 (51%)
		ATPase-Plipid	28..1051	CDD:273734	398/1096 (36%)
		E1-E2_ATPase	84..>189	CDD:278548	45/106 (42%)
		Cation_ATPase	<489..568	CDD:289987	34/78 (44%)
		HAD_like	<758..807	CDD:304363	31/49 (63%)
		PhoLip_ATPase_C	804..1050	CDD:292829	76/254 (30%)
atp11c	XP_004917005.2	P-type_ATPase_APLT_Dnf-like	42..971	CDD:319770	363/973 (37%)
atp11c	XP_004917005.2	7TMR-DISM_7TM	954..>1071	CDD:377898	36/121 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I2659
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	795	1.000	Inparanoid score	I498
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	1	1.000	-	-		FOG0004283
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.080