DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and atp10b

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_002940174.2	Gene:	atp10b / 100489696	XenbaseID:	XB-GENE-6045964	Length:	1443	Species:	Xenopus tropicalis

Alignment Length:	1280	Identity:	368/1280 - (28%)
Similarity:	581/1280 - (45%)	Gaps:	301/1280 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSF------FVNETISPLVSLLPLLFVMII 86
            |::.|||||..:|||.|.:|||.|:...||:.:..:::      |..|     ::::||..|:.:
Frog    65 NKIRTTKYTLLSFLPKNLFEQFYRSANIYFVFLAALNWVPQIGVFHKE-----ITMVPLAIVLGV 124

  Fly    87 TALKEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINS--QFIVPGDLVVVRNDGDVPCDLVLLQS 149
            .|:|:.:|||.|.:.|:.:|..:.:|......:.:..  :.:..||.|.:..:..:|.|::||..
Frog   125 IAIKDAVEDYKRYRIDRRINFTKTSVYNKNSNDFVEKCWKDVCVGDFVKLLCNEIIPADILLLFC 189

  Fly   150 SSADRKCFVNTANLDGETNLKTICVPTNYL---LAGDHELQGKDCIVCEPSSADLYTFNGRLELR 211
            |..:..|.:.|||||||||||...|...:.   :|.|.| ..::.||||..:.:|..|.|.::|.
Frog   190 SDQNGICHIETANLDGETNLKQRQVVKGFCKQGMAFDPE-SFRNTIVCEKPNNNLNKFKGYMQLD 253

  Fly   212 SG-NDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKY 275
            :| ..|.|:          ::|||||..|::||.|||..:|.|..||..||:.....|.:..|:.
Frog   254 NGQRTGFGN----------ESLLLRGCTVRNTEEVVGIVVYAGHETKAMLNNSGPRYKRSKIERQ 308

  Fly   276 IN---RFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTN---FNSAWQIFEDFLSFLLL 334
            :|   .|.|.::..|.::..:.|.|...|  .::|.: :..|..:   .:.|...|..||:.::|
Frog   309 MNINVFFCVGILFIMCLIGALGYGIWTSK--FVIPPL-FDVPEADGSYLSPALAGFYMFLTMIIL 370

  Fly   335 FNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLT 399
            ...::|||.|::||:.::..::.:|:||.|||||.|...:..|.|:.|:|||:..:|||||||||
Frog   371 LQILIPISLYVSIELVKLGQIYLIHSDLDLYDEEIDLSVQCRALNITEDLGQIQYIFSDKTGTLT 435

  Fly   400 KNLMKFVNCYVPGTNYQLQNT------HLVSEGTDE----------------------------- 429
            :|.|.|..|.:.|..:..|..      :...|..||
Frog   436 ENKMVFRRCTIVGYEFSHQENAKRLEMYNEEESDDEDMTKPRNFLFDLDAGNQSTVRHKGTKALR 500

  Fly   430 -------------------KFELEK------LDAD------------------AAV--------- 442
                               :|::.:      ::.|                  |||
Frog   501 RCHSARPNIQGHFRKKSEGRFDISQVAFSSPIEKDVTPDHMLLAKVREASVKFAAVSPLVSQSNI 565

  Fly   443 ---------LFEALAVCHTVEV---------------LQEVGD------------KTLESSESVS 471
                     .|.|||:|:||.|               |:..|.            |.|..|:|.|
Frog   566 RAASSPYIDFFLALAICNTVVVSTATEPRQRVTIPPLLKSSGSSLEKFQHLFQRLKLLSFSQSSS 630

  Fly   472 --------------------------------------------EQSHLMSRNIVDR-------- 484
                                                        :....:|:|..|.
Frog   631 TSPSSSDPGTPTSSKNNKVSPVPSADKDNISSSSSGEAECQSSGKDDSSVSKNSADNCLEEMIAT 695

  Fly   485 -----------YQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSE 538
                       |:|.||||.||:....:.......:..|.::: |.|....:.|..|:.|.|.|.
Frog   696 VSSLHIEDDFCYEAESPDEAALVHAARAYSFTLMSRTPDQVTV-RLPQGTLLTFDLLYTLGFDSV 759

  Fly   539 RQRMSVIVRDQ-SDTIWLYSKGAESAIF------------PRCKASPLVEQTDAQITKYAQNGLR 590
            |:||||:||.. :..|.:|:|||:|.|.            ...|...:..:|...:..||::|||
Frog   760 RKRMSVVVRHPITREIIVYTKGADSVIMDLLDDPSKANISDEKKLRKMQARTQRHLDWYARDGLR 824

  Fly   591 TMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGET 655
            |:.:.:::|::||...:.....:|...:.||.||:....:.:|..|.|||||.:||.|||.|.:|
Frog   825 TLCIAKKVLSEDEFERWSNFREEAEAAIENREELLMETAQHLETNLSLLGATGIEDRLQEGVPDT 889

  Fly   656 LEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDMIGDD----- 715
            :.:|:.||:.||||||||.|||.||..:|:.:.:.... |.|||.......:.||...:|
Frog   890 IASLREAGINIWVLTGDKQETAVNIAYSCQLLDQYDTV-FTINTESKETCESILDCTLEDVKKFF 953

  Fly   716 -----------------------EPEV-LIVDGTTITALLE-HTPRQFADLALRCRAVLCCRLSP 755
                                   .|:| |::||.|:..:.: ....:|.:|:..||:|||||.:|
Frog   954 PEKKKRGLFKRSKAPVSHELEAVRPQVGLVIDGRTLNVIFQGGLETKFLELSRHCRSVLCCRATP 1018

  Fly   756 LQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRL 820
            ||||.:|.|::.:.|.:|.:||||||||||||.|.|||||:|:||.||...:||:|:||:.|::|
Frog  1019 LQKSMVVKLVRDKLKVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAISRFKHLKKL 1083

  Fly   821 FLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVL 885
            .|||||:...|||.:|:::.|||:.....:..||::..:|.|.:.:...:..|::.:.|....|.
Frog  1084 LLVHGHWCYTRLANMVIYFFYKNVAYVNLLFWYQLFCGFSGTTMIDYWQMIFFNLFFTSVPPLVF 1148

  Fly   886 AICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQ---CFIIFFFTYAMLNDANVLF 947
            .|.|||.|.|||:|.|.|||.....:...|..|.:.|::.|.|   ||.|.:||| ...|.:||
Frog  1149 GILDKDISAETLMSLPHLYKSGQQCKSYKMSTFWIAIVDAFYQSLVCFFIPYFTY-QGTDIDVL- 1211

  Fly   948 NGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYTSGELY 1012
                     :|||.:.||.:....:.|.:.....|..::..|:.||..:.:.:..||     .:.
Frog  1212 ---------SFGTPINTIALFTILMHLAIEIKTWTILHWVTIVVSIICYFVVSLAYN-----AIC 1262

  Fly  1013 DVYNQFLSSLPIW---------LFTIIC---SVACLLPDFVIKVV 1045
            .:.|:  .:.|.|         ||.|:|   .|..|||.:.|:.:
Frog  1263 VLCNE--PANPYWIMEMQMSDPLFYIVCIITPVIALLPRYFIRAL 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	16/43 (37%)
		ATPase-Plipid	28..1051	CDD:273734	368/1280 (29%)
		E1-E2_ATPase	84..>189	CDD:278548	33/109 (30%)
		Cation_ATPase	<489..568	CDD:289987	28/91 (31%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	77/257 (30%)
atp10b	XP_002940174.2	P-type_ATPase_APLT_Dnf-like	64..1199	CDD:319770	337/1154 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920