DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and atp11b

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_031757992.1	Gene:	atp11b / 100135380	XenbaseID:	XB-GENE-989040	Length:	1166	Species:	Xenopus tropicalis

Alignment Length:	1057	Identity:	400/1057 - (37%)
Similarity:	599/1057 - (56%)	Gaps:	57/1057 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISPLVSLLPLLFVMIITALKEG 92
            ||:.::|||...|:|.|.:|||||...||||||.:|...::...||:.|.|||.||:.:||:|:|
Frog    50 NRIISSKYTVLNFIPKNLFEQFRRIANFYFLIIFLVQLMIDTPTSPITSGLPLFFVITVTAIKQG 114

  Fly    93 LEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADRKCF 157
            .||:.|.|:|..||.|.|.|:|:|......|:.|..||:|.|..|...|.|||||.|...|..|.
Frog   115 YEDWLRHKADNEVNGAPVYVVRSGHLVKTRSKNIRVGDIVRVAKDETFPADLVLLSSDRPDGSCH 179

  Fly   158 VNTANLDGETNLKT-ICVPTNYLLAGDHELQGKDCIV-CEPSSADLYTFNGRLELRSGNDGAGSS 220
            :.||:||||||||| ..|....:|.....|.....:: |:...||||.|.|||.:|..::....|
Frog   180 ITTASLDGETNLKTHFAVQETAVLQSAANLHTLSAVIECQQPEADLYRFVGRLTIRQHSEDIVRS 244

  Fly   221 AGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFMVALIV 285
            .|.      |||||||.|:|:|:.:.|.|:||||..|:.||.:....|.::.||.:|.|::..::
Frog   245 LGP------DNLLLRGARLKNTKEIFGVAVYTGMEAKMALNYKSKSQKRSAVEKSMNSFLLVYLI 303

  Fly   286 GMIVVVVVLYLIERHKEAKIVPTMPYQGPPT----NFNSAWQIFEDFLSFLLLFNYMVPISAYMN 346
            .::...::..:::...:|:.....|:....|    |.:...:...|||:||:|:|:::|||.|:.
Frog   304 ILLFEAILSTILKYAWQAEEKWDEPWYNQKTEHDRNSSKILKFISDFLAFLVLYNFIIPISLYVT 368

  Fly   347 IEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKFVNCYVP 411
            :|:.:..|..|:..||.||.||::|..:||.|:||||||||..:|:|||||||:|.|:|..|.|.
Frog   369 VEMQKFLGSFFIGWDLDLYHEESNQRAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSVN 433

  Fly   412 GTNYQLQNTHLVSEGTDEKF---ELEKLDADAAVLFEALAVCHTVEV----LQEVGDKTLESSES 469
            |..|:..|..||.||....|   ....|..:..:..:|:::||||::    :...|| .|..:..
Frog   434 GIKYKEINCKLVPEGVTMDFPDAPTTSLSMEEELFLKAVSLCHTVQISYDQIDGCGD-GLRFANG 497

  Fly   470 VSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLE 534
            :|.|.         .|.|||||||||:|....:|:.:.|...:::.|......|:  :|.|||||
Frog   498 MSNQF---------EYYASSPDEKALVEASRRMGVAFNGIHGEIMEIKCLGKLER--YKLLHVLE 551

  Fly   535 FSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRCKASPLVEQTDAQITKYAQNGLRTMAVGRRML 599
            |.:.|::|||||...|....|::|||||::....|... :::|...:.::|..||||:.:..|..
Frog   552 FDANRRQMSVIVESPSGEKILFTKGAESSVLCNAKLGE-IDRTRIHVDEFASKGLRTLCIAYRKF 615

  Fly   600 TDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGL 664
            :.:|....::...:|.|.|..|.|.:|..:..:|.:|.:||||.:||.||:.|.||:|||:.||:
Frog   616 SPEEYNEIDQRLHEAKTALQQREERLADVFNFIERDLVMLGATGVEDKLQDKVHETIEALRVAGI 680

  Fly   665 KIWVLTGDKVETAYNIGLACRHIPRGSKQHFII---NTTEPAELLARL-DMIGDDE--PEVLIVD 723
            |:|||||||.|||.::.|:|.|..|......::   ...|.||.|::| ..:.:|.  ...|:||
Frog   681 KVWVLTGDKHETAVSVSLSCGHFHRNMNILELVQQKTDRECAEQLSQLARRLREDHVIQHGLVVD 745

  Fly   724 GTTITALLEHTPRQFADLALRCRAVLCCRLSPLQKSEIVTLIKRR-KKYITAAIGDGANDVSMIQ 787
            |.:::..|....:.|.::...|.||||||::||||:::|.|:|.. :|.||.|:|||||||||||
Frog   746 GASLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAKVVRLLKTSPEKPITLAVGDGANDVSMIQ 810

  Fly   788 EAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMAL 852
            |||:||||.|:||:||.|.:|::||||:.|.:|.||||||...|:|.||.::.|||:.......|
Frog   811 EAHVGIGIMGKEGRQAVRNSDYAIARFKFLSKLLLVHGHYYYIRIATLVQYFFYKNVCFITPQFL 875

  Fly   853 YQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKPLAHNRQASMGV 917
            ||.|.|:|...:|:|:||.|::|.:.|....:.::.::......|.|.|.||:.::.|.......
Frog   876 YQFYCLFSQQTLYDSVYLTLYNICFTSLPILMYSLFEQHVHPHVLQSKPGLYRDISKNALLGFKP 940

  Fly   918 FSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQ--------TFGTMLITIIVIVGNLKL 974
            |..|.|.||...|:.||.:|.::.:...|...||.....        ||||::.|::||...:|:
Frog   941 FLYWTLLGFGHAFVFFFGSYFLMGEDTSLLGNGQILKPNRQLMFGNWTFGTLVFTVMVITVTMKM 1005

  Fly   975 LLVAHYMTYRNFAMILASIAAFMLTTYLYN------LYTSGELYDVYNQFLSSLPIWLFTIICSV 1033
            .|..|:.|:.|..:...|||.:.:.:..|.      |:|. ::|.|:.|.|||...|...||..:
Frog  1006 ALETHFWTWINHFVTWGSIAFYFIFSLFYGGIIWPFLHTQ-DMYFVFVQLLSSGSAWFAIIIIII 1069

  Fly  1034 ACLLPDFVIKVVNDMYR 1050
            .||..|.:.||.   ||
Frog  1070 FCLFLDVMKKVA---YR 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	20/37 (54%)
		ATPase-Plipid	28..1051	CDD:273734	400/1057 (38%)
		E1-E2_ATPase	84..>189	CDD:278548	46/105 (44%)
		Cation_ATPase	<489..568	CDD:289987	32/78 (41%)
		HAD_like	<758..807	CDD:304363	32/49 (65%)
		PhoLip_ATPase_C	804..1050	CDD:292829	84/259 (32%)
atp11b	XP_031757992.1	P-type_ATPase_APLT_Dnf-like	49..959	CDD:319770	362/927 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I2659
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	795	1.000	Inparanoid score	I498
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.160