Protein Alignment mei-41 and TRA1

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_011967.1
• Gene: TRA1 / 856499
• SGDID: S000001141
• Length: 3744
• Species: Saccharomyces cerevisiae
• Alignment Length: 3020
• Identity: 552/3020 - (18%)
• Similarity: 986/3020 - (32%)
• Gaps: 1049/3020 - (34%)

  Fly    94 PKLFERLVLAYVEAIEET------HLQLSSLDLGQLS-------------NERKPAITVRIFRCD 139
            |::.|..||||....|::      .|.||...:.:|:             |:|...:.:::...:
Yeast  1158 PEVREVGVLAYKRIYEKSCLIYGEELALSHSFIPELAKQFIHLCYDETYYNKRGGVLGIKVLIDN 1222

  Fly   140 VEC----LQEFDPHCA------IEDI--KVPLEQADMYAKSLLEVLQHAHHIGYATHGDIFSGSL 192
            |:.    |:::..:.|      ::|.  :.|....|...|.|:::|.       .|..|:
Yeast  1223 VKSSSVFLKKYQYNLANGLLFVLKDTQSEAPSAITDSAEKLLIDLLS-------ITFADV----- 1275

  Fly   193 HQALLILKECDMDTKLASLNYCHNVLRSQSASSWITNPDVGHYAQLTLEATA-IMWSAVAKWLDM 256
                   ||.|:..|:........|....:|     ||.|.:..|.:|...: :....:.|.:|.
Yeast  1276 -------KEEDLGNKVLENTLTDIVCELSNA-----NPKVRNACQKSLHTISNLTGIPIVKLMDH 1328

  Fly   257 GCMTRQELKRLNITTKLLLEVLHMRARPAHHLGYLL-------LNEILSLPT------------- 301
                         :.:.||..:.  |:|...|.:.:       :...||||.
Yeast  1329 -------------SKQFLLSPIF--AKPLRALPFTMQIGNVDAITFCLSLPNTFLTFNEELFRLL 1378

  Fly   302 --AIELDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHCHPTHLVPILALMGLKQTEMR 364
              :|.|.|...|:||:.||...|:|.  .||||.|:           ...:.:||: .||..|..
Yeast  1379 QESIVLADAEDESLSTNIQKTTEYST--SEQLVQLR-----------IACIKLLAI-ALKNEEFA 1429

  Fly   365 SGV-----VQVLTQSLVEILK-KEEVLSKDWQKLIAILRGFKQLEK---------LILSQSQHK- 413
            :..     :::|......:|| ..|:::..::.|...|....:|.|         |:::.|.|:
Yeast  1430 TAQQGNIRIRILAVFFKTMLKTSPEIINTTYEALKGSLAENSKLPKELLQNGLKPLLMNLSDHQK 1494

  Fly   414 ----------------IAEHEGHIDSSVLAMLPLQCEIIKVADTNW-NNLSMQLVELESKCSADR 461
                            ||..:..|...:|..|...|. ::|.||.: .:|:.|:.
Yeast  1495 LTVPGLDALSKLLELLIAYFKVEIGRKLLDHLTAWCR-VEVLDTLFGQDLAEQMP---------- 1548

  Fly   462 RHIHLEICSLLMQITFIRHFLKTQTQHQLLAILQRHLKLSYLCAIRLETP---------SSVHTQ 517
                   ..:::.|..|.|.|..|....|..:|.:.:.|.....::|::|         :..|..
Yeast  1549 -------TKIIVSIINIFHLLPPQADMFLNDLLLKVMLLERKLRLQLDSPFRTPLARYLNRFHNP 1606

  Fly   518 MQSFYAQQ--------YM-RLFQSEETQEI--------------FCSNLPQ---LYISGFIKPEQ 556
            :..::.:.        :| .:.|..|.:|:              :.||:|:   ..:|.|.....
Yeast  1607 VTEYFKKNMTLRQLVLFMCNIVQRPEAKELAEDFEKELDNFYDFYISNIPKNQVRVVSFFTNMVD 1671

  Fly   557 LMKALPTINNRSGRAQVIRLLLCSQPGKLSVFKVKDRIELYCPKCRPLP------------KKLP 609
            |...:...|...         ...:.|.: :.|:||.:.|.....:...            .|..
Yeast  1672 LFNTMVITNGDE---------WLKKKGNM-ILKLKDMLNLTLKTIKENSFYIDHLQLNQSIAKFQ 1726

  Fly   610 GIYLG----KCKQQLPC----PDFS---------------------STNLE----MIANDLLFYP 641
            .:||.    ..:.|.|.    .|||                     |:|.|    .|.:..||..
Yeast  1727 ALYLRFTELSERDQNPLLLDFIDFSFSNGIKASYSLKKFIFHNIIASSNKEKQNNFINDATLFVL 1791

  Fly   642 DFECIAQHLDLLCFEPNVILGLLRETEALQKVSVKVIGQLVS-AMRVRSPEFLEQLANLVLAAIK 705
            ..:|:...:.:|   .|||...|     :.:|:..  |.|.| .:..:.|::||.|.|.:.....
Yeast  1792 SDKCLDARIFVL---KNVINSTL-----IYEVATS--GSLKSYLVEDKKPKWLELLHNKIWKNSN 1846

  Fly   706 AMLAKPLTEQNVLQQRSMLNVLTAIAHMEDNEIWL--------FHWFKMTFFFLVHTRSLVAQEA 762
            |:||..:.:.:.|.:..:|. |:||....|.||..        |.|   .|..|..|  |:.|.|
Yeast  1847 AILAYDVLDHHDLFRFELLQ-LSAIFIKADPEIIAEIKKDIIKFCW---NFIKLEDT--LIKQSA 1905

  Fly   763 VLAATEMCASQGLQTIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRSLRALTKMLGFTCVQEFT 827
            .|..:                |.....|..:::...|:    |...||.....:.|....:...|
Yeast  1906 YLVTS----------------YFISKFDFPIKVVTQVF----VALLRSSHVEARYLVKQSLDVLT 1950

  Fly   828 CKYHRLLTAMVLPHCIVNPLCKGVLVLIAKQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIE 892
            ...|..:.|...|...:| ..|.|:|..:.. |.:|            .:.||...|:|
Yeast  1951 PVLHERMNAAGTPDTWIN-WVKRVMVENSSS-QNNI------------LYQFLISHPDL------ 1995

  Fly   893 LVVSCTQSSLQQLMNADVKQTVAELLIYFNRNPTFVMRSFQSLLQLSIGSLEELSSQTANAEFAN 957
                                       :||....|:......:.:::..|.....|.|...:.|:
Yeast  1996 ---------------------------FFNSRDLFISNIIHHMNKITFMSNSNSDSHTLAIDLAS 2033

  Fly   958 FIAERFLGVITYFESCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQE 1022
                    :|.|:|:...|.:.....|.:   |.|.::.......:........|::...:. ..
Yeast  2034 --------LILYWENKTLEITNVNNTKTD---SDGDVVMSDSKSDINPVEADTTAIIVDANN-NS 2086

  Fly  1023 P---RLQRICLKIWHIFLHVVNVQELGPSLG-RIVATLQPLLAD----NESVKQVNDLYEFIILR 1079
            |   .|:..|......::...|.:.:...|| |.:..|..|::|    |.:||.|. ..:|:|.:
Yeast  2087 PISLHLREACTAFLIRYVCASNHRAIETELGLRAINILSELISDKHWTNVNVKLVY-FEKFLIFQ 2150

  Fly  1080 NAS--------MLGTFITDLYFLDR-----MENVSPSIQ----KCIRRHTAHLDLKGLAEEENQS 1127
            :..        |....:..::|.::     |||: |:||    |||:  :.|.|::
Yeast  2151 DLDSENILYYCMNALDVLYVFFKNKTKEWIMENL-PTIQNLLEKCIK--SDHHDVQ--------- 2203

  Fly  1128 PPLVDQLRFLQKHITDECLQVRVYAL--QHLGDLFGRRRP------KLNSTILSELP-------- 1176
                   ..|||     .|||.:.|:  |.:..:.....|      .|.|.|..:|.
Yeast  2204 -------EALQK-----VLQVIMKAIKAQGVSVIIEEESPGKTFIQMLTSVITQDLQETSSVTAG 2256

  Fly  1177 --------------LEPMLEQIVNVLMAGCQHDDSQLQMASAKCLGELGAIDASYLPSNYNFASP 1227
                          :.|:|..::......|:...|..|...|..|.| ..|....|.......|
Yeast  2257 VTLAWVLFMNFPDNIVPLLTPLMKTFSKLCKDHLSISQPKDAMALEE-ARITTKLLEKVLYILS- 2319

  Fly  1228 QHLPLNILSDD-FAVLALTSLCRGYQFQQN--TKHVDS-----FSLAIQETLAICGISPKEQKKV 1284
              |.:::|.|. ...|:..:|...:...||  .|.|:.     |:..|..|:        ::|..
Yeast  2320 --LKVSLLGDSRRPFLSTVALLIDHSMDQNFLRKIVNMSRSWIFNTEIFPTV--------KEKAA 2374

  Fly  1285 QLWQSLPARMRQLMEPMLHSCYTCV--------HRPST----CLQQP-LFGSHY----------- 1325
            .|.:.|...:|.  ||.|...:..:        |..:|    .::|| |.|:..
Yeast  2375 ILTKMLAFEIRG--EPSLSKLFYEIVLKLFDQEHFNNTEITVRMEQPFLVGTRVEDIGIRKRFMT 2437

  Fly  1326 -----------SHNYY----EEWAFL----WASRLIDYLPSSGRRHLLSSYKPCIKRDSNMLSTF 1371
                       ...||    :.|.|:    |.::.:..|..|..|....|.|       |:....
Yeast  2438 ILDNSLERDIKERLYYVIRDQNWEFIADYPWLNQALQLLYGSFNREKELSLK-------NIYCLS 2495

  Fly  1372 YPYILLHALLECTTEQRNHIQEEFMAVLQANE-ESSSSVRGRQELGAIKENAFKQFESRKYAAGI 1435
            .|.||           :.::.|....|.:.|: |.|:.|:|                   :.|.:
Yeast  2496 PPSIL-----------QEYLPENAEMVTEVNDLELSNFVKG-------------------HIASM 2530

  Fly  1436 KPLASTLVSDRKEDSSRVPRLAGKLCAELLDFL------------QRWLREWQRIH-----GRST 1483
            :.|...:.||                  .:|.|            :.|:..:.:::     ....
Yeast  2531 QGLCRIISSD------------------FIDSLIEIFYQDPKAIHRAWVTLFPQVYKSIPKNEKY 2577

  Fly  1484 G---------GKPPET--IDSNYRKIHEFLNLIPKL--------LVSRASYNCGEYARALSYLES 1529
            |         .||..|  |.|....|:..|:.|.|:        ||...:.:...:.::::.|||
Yeast  2578 GFVRSIITLLSKPYHTRQISSRTNVINMLLDSISKIESLELPPHLVKYLAISYNAWYQSINILES 2642

  Fly  1530 YLEEGEDKSQRLLE-QFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMITS 1593
            ........:.:::| ....|:|:|.:|::.|...|              :...|....:.::..|
Yeast  2643 IQSNTSIDNTKIIEANEDALLELYVNLQEEDMFYG--------------LWRRRAKYTETNIGLS 2693

  Fly  1594 YEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFAECKSELLWRLGS- 1657
            |||:                                |||.:....|.   .|:.|:    |.|:
Yeast  2694 YEQI--------------------------------GLWDKAQQLYE---VAQVKA----RSGAL 2719

  Fly  1658 -YDEMEEL--QSNWPAQCSQGCLKLRR-----PLTTRIEFDSLL--------------DGMRESV 1700
             |.:.|..  :.|| .||::   ||:.     .|.....|..||              |.:.:||
Yeast  2720 PYSQSEYALWEDNW-IQCAE---KLQHWDVLTELAKHEGFTDLLLECGWRVADWNSDRDALEQSV 2780

  Fly  1701 ----------LEELRSCSAVQQHSYA--------NAYDAVLKLHLV------------HE--LHC 1733
                      .:..::..|:|..:.:        ...|..::|.|:            |:  ||.
Yeast  2781 KSVMDVPTPRRQMFKTFLALQNFAESRKGDQEVRKLCDEGIQLSLIKWVSLPIRYTPAHKWLLHG 2845

  Fly  1734 SQELVEKLE-------------QDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRN- 1784
            .|:.:|.||             |:.|...||  :|.....|:.||......|.:...:.::|::
Yeast  2846 FQQYMEFLEATQIYANLHTTTVQNLDSKAQE--IKRILQAWRDRLPNTWDDVNMWNDLVTWRQHA 2908

  Fly  1785 ----------ILAELQRRLTDRNHLLPHLKTELAR-----IWLNSAQINRNAGQL---------- 1824
                      ::..||:..::.|     :.|...|     .|:    |||.|...
Yeast  2909 FQVINNAYLPLIPALQQSNSNSN-----INTHAYRGYHEIAWV----INRFAHVARKHNMPDVCI 2964

  Fly  1825 -QRAQLYILKAAEYQPSGLFI-ERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRH 1887
             |.|::|.|...|.|.:.|.: |:||..:|.      ||.|...|.::.:   .|:......|:.
Yeast  2965 SQLARIYTLPNIEIQEAFLKLREQAKCHYQN------MNELTTGLDVISN---TNLVYFGTVQKA 3020

  Fly  1888 LFF--RGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEP 1950
            .||  :|.:|..:.:.|..:       :.|..|:.:.........|...|.::.|      ..||
Yeast  3021 EFFTLKGMFLSKLRAYEEAN-------QAFATAVQIDLNLAKAWAQWGFFNDRRL------SEEP 3072

  Fly  1951 TGEQDDMLINVMVNYAKSL-RYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTA- 2013
              .......|.:..|.::. .|.:..:.:.:.|:  |||.:.:.::.         :|||...:
Yeast  3073 --NNISFASNAISCYLQAAGLYKNSKIRELLCRI--LWLISIDDASG---------MLTNAFDSF 3124

  Fly  2014 ---LPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQ------------------QSL 2057
               :|...:.|...|:|:.|.|...:   ::|:::|::.::|||                  |::
Yeast  3125 RGEIPVWYWITFIPQLLTSLSHKEAN---MVRHILIRIAKSYPQALHFQLRTTKEDFAVIQRQTM 3186

  Fly  2058 ------------------WMLL--------------------------PHFKSAKAHRIKR-CKL 2077
                              |..|                          ..|||.....:.| ..:
Yeast  3187 AVMGDKPDTNDRNGRRQPWEYLQELNNILKTAYPLLALSLESLVAQINDRFKSTTDEDLFRLINV 3251

  Fly  2078 VLTDS--------------RLQNSTFQKLLQ-----------------------DFNSLTERL-- 2103
            :|.|.              :|..:|.:.|::                       |:.:..:||
Yeast  3252 LLIDGTLNYNRLPFPRKNPKLPENTEKNLVKFSTTLLAPYIRPKFNADFIDNKPDYETYIKRLRY 3316

  Fly  2104 --MDLTNKEVTLDRTYKLSDLDT---RLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSH 2163
              ..|.||   |||..|..:|:.   .||....| :|..|.:| .:|:     ||.|:|
Yeast  3317 WRRRLENK---LDRASKKENLEVLCPHLSNFHHQ-KFEDIEIP-GQYL-----LNKDNN------ 3365

  Fly  2164 LPANQSTVNWFPYQQIYISGFQESVLILRSA-AKPKKLTIRCSDGKDYDVLVK--PKDDLRRDAR 2225
                   |::     |.|:.|..:|..:|.. :..::|.||..||..:...|:  .....||:.|
Yeast  3366 -------VHF-----IKIARFLPTVDFVRGTHSSYRRLMIRGHDGSVHSFAVQYPAVRHSRREER 3418

  Fly  2226 LMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPF--------------------NEECGLVEWLP- 2269
            :.:...|..:.|.::...|:|.:.......:|.                    ||.|....:.|
Yeast  3419 MFQLYRLFNKSLSKNVETRRRSIQFNLPIAIPLSPQVRIMNDSVSFTTLHEIHNEFCKKKGFDPD 3483

  Fly  2270 NLASYRSICMN------LYAQRRLVMST---RQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQ 2325
            ::..:.:..:|      |.|....::..   ..:|::.||.:...:....:||:         |:
Yeast  3484 DIQDFMADKLNAAHDDALPAPDMTILKVEIFNSIQTMFVPSNVLKDHFTSLFTQ---------FE 3539

  Fly  2326 E-WL-RQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFN 2388
            : || |::||:.:|.:             ..:.|::.:.:|....|...:.:|:...:
Yeast  3540 DFWLFRKQFASQYSSF-------------VFMSYMMMINNRTPHKIHVDKTSGNVFTL------- 3584

  Fly  2389 QGELLP--YP-------------------------EVVPFRLTHNMIVAMGPLGVEGSFRKCCEI 2426
              |:||  :|                         |.||||||.|:...:|...:||.|......
Yeast  3585 --EMLPSRFPYERVKPLLKNHDLSLPPDSPIFHNNEPVPFRLTPNIQSLIGDSALEGIFAVNLFT 3647

  Fly  2427 TLRLLKQESKTLMSILRPFVYD--------------VGAQTRKGAATAKITKDVQRIADRLQGHV 2477
            ..|.|.:....|.:.|..|:.|              ...|.|:...| .:...::::|.  .||:
Yeast  3648 ISRALIEPDNELNTYLALFIRDEIISWFSNLHRPIIENPQLREMVQT-NVDLIIRKVAQ--LGHL 3709

  Fly  2478 KRQQANSIPLSTEGQVNFLINEATKVDNLA 2507
                 ||.|..|...:...|..|....|||
Yeast  3710 -----NSTPTVTTQFILDCIGSAVSPRNLA 3734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	17/108 (16%)
		FAT	1653..1985	CDD:280429	82/430 (19%)
		PIKKc_ATR	2181..2448	CDD:270625	62/328 (19%)
		FATC	2486..2517	CDD:280430	7/22 (32%)
TRA1	NP_011967.1	TEL1	1232..3744	CDD:227365	537/2946 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900