Protein Alignment mei-41 and PIK1

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_014132.1
• Gene: PIK1 / 855454
• SGDID: S000005211
• Length: 1066
• Species: Saccharomyces cerevisiae
• Alignment Length: 1133
• Identity: 212/1133 - (18%)
• Similarity: 397/1133 - (35%)
• Gaps: 343/1133 - (30%)

  Fly  1492 DSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLR 1556
            |.|. ||||  |:.|.|::|....:...:.: ||.:...|.|.:.:.|:   .|.|.:
Yeast   147 DKNV-KIHE--NVAPALVLSSMIMSAIAFPQ-LSEVTKPLVESQGRRQK---AFVFKL------- 197

  Fly  1557 DPDSVEGAVQVRSYDMSVTQDI-LVNRLVERQQDMITSYEQLLSSTDQMQP-------DHVRAMI 1613
                      .||.....|::: |.|.|:.::    ||..:.:||.....|       |.::...
Yeast   198 ----------ARSAMKDFTKNMTLKNTLLNKK----TSRSKRVSSNRSSTPTSPIDLIDPIKTKE 248

  Fly  1614 DAYLRDTPKT-AQL---IADGLW-----QRLSD---------RYSDQCFAE-------------- 1646
            ||..|.:..: .:|   |.|.:.     :|:|.         :|.|..:..
Yeast   249 DASFRKSRHSEVKLDFDIVDDIGNQVFEERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSI 313

  Fly  1647 ---------CKSELLWRLGSYDEMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLE 1702
                     .|.:.:...|..||..|:.:|......:          |..:.|:|......|.:.
Yeast   314 SNTAKALDGNKGDYISPKGRNDENNEIGNNEDETGGE----------TEEDADALNSDHFTSSMP 368

  Fly  1703 ELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQE------------KLMK 1755
            :|.:.......:.:.:.:...||:..:....|::..:..::.....:||            |::|
Yeast   369 DLHNIQPRTSSASSASLEGTPKLNRTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLK 433

  Fly  1756 -NYF----------DDWQYRLQIVQPQVR---IQESIYSFRRNILAELQRRLTDRNHLLPHLKT- 1805
             |||          :....||..|..:.|   ::..::...|::.||:     |...|||..|.
Yeast   434 ANYFRCETQFAIALETISQRLARVPTEARLSALRAELFLLNRDLPAEV-----DIPTLLPPNKKG 493

  Fly  1806 ---ELARIWLNSAQINRNAGQLQRAQL--YILKAAEYQPSGLFIER--AKLLWQKGDQVMAMNYL 1863
               :|..|..|.||:..:|.::....|  |:....::.|:....||  .|:...:|..:..:||:
Yeast   494 KLHKLVTITANEAQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYM 558

  Fly  1864 EEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSES- 1927
            ..:    .:....|...|.:....        .:||.:.|.:..|..     .|.::...:|:|
Yeast   559 NRK----ENNENRNESTLTSNNTR--------SSVYDSNSFNNGASR-----NEGLSSTSRSDSA 606

  Fly  1928 --CHVQMAQFLEKILEARQGGKSEPTGEQD--DMLINVMVNYAKSLRYGSEHVYQSMPRLISLWL 1988
              .||                ::|...|:|  ||.:..:.|......|.:..|.||...:..|..
Yeast   607 STAHV----------------RTEVNKEEDLGDMSMVKVRNRTDDEAYRNALVIQSAANVPILPD 655

  Fly  1989 DTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFT---VLRNVIIKLVE 2050
            |:.:.|........::::|              :.:.:.|:..|...|...   .:..|::..::
Yeast   656 DSQDRSPELNFGSNLDEVL--------------IENGINSKNIHSQTDALADQMRVSAVMLAQLD 706

  Fly  2051 AYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLT-ERLMDLTNKEVT-- 2112
            ..|||         .|....:| |.:::.:...:|:......|:..:.:. ||  .|.|..:|
Yeast   707 KSPQQ---------LSESTKQI-RAQIISSMKEVQDKFGYHDLEALHGMAGER--KLENDLMTGG 759

  Fly  2113 LDRTYKLSDLDTRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQ 2177
            :|.:|...|..|:..::.|..|:..    ||                            ||
Yeast   760 IDTSYLGEDWATKKERIRKTSEYGH----FE----------------------------NW---- 788

  Fly  2178 QIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLME-FNGLVKRYLHQDA 2241
                                    ..||      |:.|..||||::|...: ...:...::.:..
Yeast   789 ------------------------DLCS------VIAKTGDDLRQEAFAYQMIQAMANIWVKEKV 823

  Fly  2242 PARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIE 2306
            ....:|:.|     |..:...||||.:.|..|..||        :..::.:.::...:.....|.
Yeast   824 DVWVKRMKI-----LITSANTGLVETITNAMSVHSI--------KKALTKKMIEDAELDDKGGIA 875

  Fly  2307 RKREVFTKQLVPAHPPVFQEWLRQRFATPH--SWYEARNTYIRTVAVMSMVGYILGLGDRHGENI 2369
            ...:.|.:                .|..|:  .:..|::.:..::|..|::.|:|.:.|||..||
Yeast   876 SLNDHFLR----------------AFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNI 924

  Fly  2370 LFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEG-SFRKCCEIT---LRL 2430
            :. :..|...|:||..:.:........|..||:||:..|..:|  |||| :|:|..|:|   .:.
Yeast   925 MI-DNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLG--GVEGEAFKKFVELTKSSFKA 986

  Fly  2431 LKQESKTLMSI--------LRPFVYDVGAQTRKGAATAKITKDVQRIADRLQGHVKRQQANSIPL 2487
            |::.:..::|:        ::| .:|.|.||                      .|:.:|...:.|
Yeast   987 LRKYADQIVSMCEIMQKDNMQP-CFDAGEQT----------------------SVQLRQRFQLDL 1028

  Fly  2488 STEGQV-----NFLINEATKVDNLASMY 2510
            | |.:|     ||||.:     :|.|:|
Yeast  1029 S-EKEVDDFVENFLIGK-----SLGSIY 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	68/370 (18%)
		PIKKc_ATR	2181..2448	CDD:270625	56/281 (20%)
		FATC	2486..2517	CDD:280430	11/30 (37%)
PIK1	NP_014132.1	TEL1	<1..1066	CDD:227365	212/1133 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900