DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and TOR2

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_012719.2 Gene:TOR2 / 853632 SGDID:S000001686 Length:2474 Species:Saccharomyces cerevisiae


Alignment Length:2846 Identity:573/2846 - (20%)
Similarity:985/2846 - (34%) Gaps:969/2846 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LLYNHVNRNVSNFSGVYSVIEDILCQEPSLISCSLVRELHNKFQDTFLLWLLN---KLAKCLSES 72
            |||.:||          |::::|..                ..:|..|:..|:   .|.|||:..
Yeast   257 LLYPYVN----------SILDNIWV----------------PLRDAKLIIRLDAAVALGKCLTII 295

  Fly    73 PDSSECINLQ--RKILSSCCSNHPKLFERLVLAYVEAIEETHL---QLSSLDLGQLSNE----RK 128
            .|....:..|  :::...|...       |.|...:::..|.|   :|.||....|.::    .|
Yeast   296 QDRDPALGKQWFQRLFQGCTHG-------LSLNTNDSVHATLLVFRELLSLKAPYLRDKYDDIYK 353

  Fly   129 PAITVRIFRCDV---------ECLQEFDPHCAIEDIKVPLEQADMYAKSLLEVLQHAHHIGYATH 184
            ..:..:.::.||         ..|..|||              .::.|..|:.:. .|::.|   
Yeast   354 STMKYKEYKFDVIRREVYAILPLLAAFDP--------------AIFTKKYLDRIM-VHYLRY--- 400

  Fly   185 GDIFSGSLHQALLILKECDMDTKLASLNYCHN-----VLRSQSASSWITNPDVGHYAQLTLEATA 244
                          ||..||       |..:|     :|.|....::.....:..|..|.|:.  
Yeast   401 --------------LKNIDM-------NAANNSDKPFILVSIGDIAFEVGSSISPYMTLILDN-- 442

  Fly   245 IMWSAVAKWLDMGCMTRQEL-KRLNITTKLLLEVLHMRARP--AHHLGYLLLNEILSLPTAIELD 306
                     :..|..|:.:: |:........:..|.....|  |.||...|||.:|:.|    :.
Yeast   443 ---------IREGLRTKFKVRKQFEKDLFYCIGKLACALGPAFAKHLNKDLLNLMLNCP----MS 494

  Fly   307 DGLLETLSSYIQGQLEHSVVPLEQLVHLQQL-MLSHWHCHPTHLVPILALMGLKQTEMRSGVVQV 370
            |.:.|||..     |...:..||..|:.:.| :||            ::|.|.|  .::|.....
Yeast   495 DHMQETLMI-----LNEKIPSLESTVNSRILNLLS------------ISLSGEK--FIQSNQYDF 540

  Fly   371 LTQSLVE---------ILKKEEVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEGHIDSSVL 426
            ..|..:|         .:||....:.|......:::.||.|:   |...|:.:.           
Yeast   541 NNQFSIEKARKSRNQSFMKKTGESNDDITDAQILIQCFKMLQ---LIHHQYSLT----------- 591

  Fly   427 AMLPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIHLEICSLLMQITFIRHFLKTQTQ---- 487
                   |.:::...::         :|.:.|:.|:...|..|.|     ||:..:..||.    
Yeast   592 -------EFVRLITISY---------IEHEDSSVRKLAALTSCDL-----FIKDDICKQTSVHAL 635

  Fly   488 HQLLAILQRHLKLSY---LCAIRLETPSSVHTQMQSFYAQ-QYMRLFQSEETQEIFCSNLPQLYI 548
            |.:..:|.:.|.::.   :..||||....:.:......|| ..:||.......|||...|..:.|
Yeast   636 HSVSEVLSKLLMIAITDPVAEIRLEILQHLGSNFDPQLAQPDNLRLLFMALNDEIFGIQLEAIKI 700

  Fly   549 SGFIKPEQLMKALPTINNRSGRAQVIRLLLCSQPGKLSVFKVKDRIELYCPKCRPLPKKLPGIYL 613
            .|.:........:|::     |..::.||                .:|   |...:|||      
Yeast   701 IGRLSSVNPAYVVPSL-----RKTLLELL----------------TQL---KFSNMPKK------ 735

  Fly   614 GKCKQQLPCPDFSSTNLEMIANDLLFYPDFECIAQHLDLLCFEPNVILGLLRE-TEALQKVSVKV 677
               |::      |:|.|..:.|.     ..|....::|.:.   :|||...:: :.|:...::||
Yeast   736 ---KEE------SATLLCTLINS-----SDEVAKPYIDPIL---DVILPKCQDASSAVASTALKV 783

  Fly   678 IGQLVSAMRVRSPEFLEQLANLV----------------------LAAIKAMLAKPLTEQNVLQQ 720
            :|:|..........:|::|..|:                      |||....:..||     |..
Yeast   784 LGELSVVGGKEMTRYLKELMPLIINTFQDQSNSFKRDAALTTLGQLAASSGYVVGPL-----LDY 843

  Fly   721 RSMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVH-TRSLVAQEAVLAATEMCASQGLQTIHLWNWY 784
            ..:|.:|..|...|:|.               | .|..|....:|.|.:.              |
Yeast   844 PELLGILINILKTENNP---------------HIRRGTVRLIGILGALDP--------------Y 879

  Fly   785 KRDALDLT-------------VRLALNVYLLDGVRFTRS-------LRALTKMLGFTCVQEFTCK 829
            |...:::|             :.:||   |:.||..:..       :..|.|:|     .:.:..
Yeast   880 KHREIEVTSNSKSSVEQNAPSIDIAL---LMQGVSPSNDEYYPTVVIHNLMKIL-----NDPSLS 936

  Fly   830 YHRLLTAMVLPHCIVNPLCKGVLVLIAKQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIELV 894
            .|.......:.|...|                 :| |..:|||           .::....|.::
Yeast   937 IHHTAAIQAIMHIFQN-----------------LG-LRCVSFL-----------DQIIPGIILVM 972

  Fly   895 VSCTQSSL----QQL--MNADVKQTVAELL--IYFNRNPTFVMRSFQSL--LQLSIGSLEELSSQ 949
            .||..|.|    |||  :.:.|||.:...:  ||      .|:|.|..:  ||::|.|:.|..|:
Yeast   973 RSCPPSQLDFYFQQLGSLISIVKQHIRPHVEKIY------GVIREFFPIIKLQITIISVIESISK 1031

  Fly   950 TANAEFANFIAERFLGVITYFESCLSEPSFEK---PLK-EETLYSLGQ--------IMRFVGSQH 1002
            ....||..|:.|    .:|:|...|......|   |:: .::|.:.|.        ||..|  ..
Yeast  1032 ALEGEFKRFVPE----TLTFFLDILENDQSNKRIVPIRILKSLVTFGPNLEDYSHLIMPIV--VR 1090

  Fly  1003 VTQFRFKIIAMLSFVHTLQEPRLQRICLKIWHIFLHVVNVQELGPSLGRIVATLQPLL--ADNES 1065
            :|::....:..:|.:      .|.|:...|        |:.|:.   .|||..|..:|  .|.|.
Yeast  1091 MTEYSAGSLKKISII------TLGRLAKNI--------NLSEMS---SRIVQALVRILNNGDREL 1138

  Fly  1066 VKQVNDLYEFIILRNASMLGT-FITDLYFLDRMENVSPSIQKCIRR----HTAHLDLKGLAEEEN 1125
            .|...:....::|:    ||| |:..:          |.|.|.:.|    |:.:           
Yeast  1139 TKATMNTLSLLLLQ----LGTDFVVFV----------PVINKALLRNRIQHSVY----------- 1178

  Fly  1126 QSPPLVDQLRFLQKHITDECLQVRVYALQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVLMA 1190
                  |||  :.|.:.:|||...:        :|.:.         :|:|.....|        
Yeast  1179 ------DQL--VNKLLNNECLPTNI--------IFDKE---------NEVPERKNYE-------- 1210

  Fly  1191 GCQHDDSQLQMASAKCLGELGAIDASYLPSNYNFASPQHLPLNILSDDFAVLALTSLCRGYQFQQ 1255
                |:.|:                :.||.|.          |||.:.:           |..||
Yeast  1211 ----DEMQV----------------TKLPVNQ----------NILKNAW-----------YCSQQ 1234

  Fly  1256 NTKHVDSFSLAIQETLAICGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPSTCLQQPL 1320
            .||                          :.||                                
Yeast  1235 KTK--------------------------EDWQ-------------------------------- 1241

  Fly  1321 FGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKPCIKRDSNMLSTFYPYI--LLHA-LLE 1382
                       ||....:.:|:...||:           |::..|:::|.:||..  |.:| ...
Yeast  1242 -----------EWIRRLSIQLLKESPSA-----------CLRSCSSLVSVYYPLARELFNASFSS 1284

  Fly  1383 CTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRK 1447
            |..|.:...||:.:..|                                   .|.|:|       
Yeast  1285 CWVELQTSYQEDLIQAL-----------------------------------CKALSS------- 1307

  Fly  1448 EDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKP-PETIDSNYRKIHEFLNLIPKLLVS 1511
              |...|.:. ::...|::|::.             ..|| |                ||...:.
Yeast  1308 --SENPPEIY-QMLLNLVEFMEH-------------DDKPLP----------------IPIHTLG 1340

  Fly  1512 RASYNCGEYARALSYLE-SYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQ-VRSYDMSV 1574
            :.:..|..:|:||.|.| .:|||.::.:      ...|:.:...|...||..|.:: .:.::...
Yeast  1341 KYAQKCHAFAKALHYKEVEFLEEPKNST------IEALISINNQLHQTDSAIGILKHAQQHNELQ 1399

  Fly  1575 TQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRY 1639
            .::....:| :|.:|.:.:|.:..::.:    |.|..|:.       |...|.|.|.|:.||...
Yeast  1400 LKETWYEKL-QRWEDALAAYNEKEAAGE----DSVEVMMG-------KLRSLYALGEWEELSKLA 1452

  Fly  1640 SDQCFAECKSEL-----------LWRLGSYDEMEELQSNWPAQCS-----QGCLKLRRPLTTRIE 1688
            |:: :...|.|:           .|.|..:||:.:..|...:|..     ...|.|.|....:.|
Yeast  1453 SEK-WGTAKPEVKKAMAPLAAGAAWGLEQWDEIAQYTSVMKSQSPDKEFYDAILCLHRNNFKKAE 1516

  Fly  1689 FDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQELV--EKLEQDRDEDNQE 1751
            ..  :...|:.::.||   ||:...||..||:.|::..::.||   :|::  :||.|:.|    :
Yeast  1517 VH--IFNARDLLVTEL---SALVNESYNRAYNVVVRAQIIAEL---EEIIKYKKLPQNSD----K 1569

  Fly  1752 KLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQ 1816
            :|...  :.|..||...|..:.:.:.|...|..::.                ..|.|::.:..|.
Yeast  1570 RLTMR--ETWNTRLLGCQKNIDVWQRILRVRSLVIK----------------PKEDAQVRIKFAN 1616

  Fly  1817 INRNAGQLQRAQLYI------------LKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSI 1869
            :.|.:|::..|:..:            ...|:..|..::.: .|.||..|.|..|:..|....|.
Yeast  1617 LCRKSGRMALAKKVLNTLLEETDDPDHPNTAKASPPVVYAQ-LKYLWATGLQDEALKQLINFTSR 1680

  Fly  1870 MRS--GCQGN--VKQLAAEQ-----RHLFFRGKYLQAVYSAE-SMHLC---------ADAVLKYF 1915
            |..  |...|  :.|...:|     ||:....|.|...:..: ...:|         .|::|..:
Yeast  1681 MAHDLGLDPNNMIAQSVPQQSKRVPRHVEDYTKLLARCFLKQGEWRVCLQPKWRLSNPDSILGSY 1745

  Fly  1916 QEAIAVHRQS---ESCH------VQMAQFLEKILEARQGGKSEPT----GEQDDMLINVMVNYAK 1967
              .:|.|..:   ::.|      .::...|..:.:.:|.|....:    .|.|:.:|.|....||
Yeast  1746 --LLATHFDNTWYKAWHNWALANFEVISMLTSVSKKKQEGSDASSVTDINEFDNGMIGVNTFDAK 1808

  Fly  1968 SLRYGSEHVY----------------------QSMPRLISLWLDTTESSTNTEQVKKMNDLLTNC 2010
            .:.|.|..::                      |...||::||.........|:.:.:..:|    
Yeast  1809 EVHYSSNLIHRHVIPAIKGFFHSISLSESSSLQDALRLLTLWFTFGGIPEATQAMHEGFNL---- 1869

  Fly  2011 CTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHR---- 2071
               :....:..|..|::||:..|...|...|.:::..|.:|:||..::.|:...||....|    
Yeast  1870 ---IQIGTWLEVLPQLISRIHQPNQIVSRSLLSLLSDLGKAHPQALVYPLMVAIKSESLSRQKAA 1931

  Fly  2072 ---IKRCKL---VLTD---------------------------SR-------------------- 2083
               |::.::   ||.|                           ||                    
Yeast  1932 LSIIEKMRIHSPVLVDQAELVSHELIRMAVLWHEQWYEGLDDASRQFFGEHNTEKMFAALEPLYE 1996

  Fly  2084 --------LQNSTFQKLL-QDFNSLTERLM------DLTNKEVTLDRTYKLSDLDTRLSKLCKQ- 2132
                    |:..:||... :|.|...|.||      |::|.....|..|.:      ..|:.|| 
Yeast  1997 MLKRGPETLREISFQNSFGRDLNDAYEWLMNYKKSKDVSNLNQAWDIYYNV------FRKIGKQL 2055

  Fly  2133 PEFSQILLPFEKYMQPTLPLNSD-------SNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLI 2190
            |:...:.|   :::.|.|....|       :.:|.|..:              :.||.|:....:
Yeast  2056 PQLQTLEL---QHVSPKLLSAHDLELAVPGTRASGGKPI--------------VKISKFEPVFSV 2103

  Fly  2191 LRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAV 2255
            :.|..:|:|..|:.||||||..::|..:|:|:|:.:|:..|||...|..||...:|.|.|:.|..
Yeast  2104 ISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPA 2168

  Fly  2256 LPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAV-PLHESIE--RKREVFTKQLV 2317
            :|.:.:.||:.|:||..::..:.......:::.::......|.: |.::::.  :|.||||..|.
Yeast  2169 IPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQMAPDYDNLTLLQKVEVFTYALN 2233

  Fly  2318 PAHPPVFQE--WLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVH 2380
            ........:  ||:.|  :..:|.|.|.||.|::|||||.||||||||||..|::.....|..:|
Yeast  2234 NTEGQDLYKVLWLKSR--SSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIH 2296

  Fly  2381 VDFNCLFNQGELL-PYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRP 2444
            :||...|....|. .:||.||||||..:..||...|:|||||..||..:::|:....:||:||..
Yeast  2297 IDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEA 2361

  Fly  2445 FVYD-----------------VGAQ---------TRKGAATAKITKDVQ---------------- 2467
            |.:|                 .|.|         ...||.|.:..:.|:                
Yeast  2362 FAFDPLINWGFDLPTKKIEEETGIQLPVMNANELLSNGAITEEEVQRVENEHKNAIRNARAMLVL 2426

  Fly  2468 -RIADRLQGH-VKRQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAF 2516
             ||.|:|.|: ::|.....:|    .||:.||.:||.|:||...||||..|
Yeast  2427 KRITDKLTGNDIRRFNDLDVP----EQVDKLIQQATSVENLCQHYIGWCPF 2473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 24/116 (21%)
FAT 1653..1985 CDD:280429 79/404 (20%)
PIKKc_ATR 2181..2448 CDD:270625 97/272 (36%)
FATC 2486..2517 CDD:280430 15/31 (48%)
TOR2NP_012719.2 TEL1 290..2474 CDD:227365 562/2787 (20%)
HEAT repeat 599..620 CDD:293787 5/29 (17%)
HEAT repeat 642..667 CDD:293787 6/24 (25%)
HEAT repeat 677..707 CDD:293787 8/29 (28%)
HEAT repeat 715..748 CDD:293787 12/71 (17%)
HEAT repeat 758..787 CDD:293787 8/31 (26%)
HEAT repeat 801..828 CDD:293787 2/26 (8%)
HEAT repeat 843..873 CDD:293787 8/44 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.