Protein Alignment mei-41 and MEC1

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_009694.3
• Gene: MEC1 / 852433
• SGDID: S000000340
• Length: 2368
• Species: Saccharomyces cerevisiae
• Alignment Length: 2743
• Identity: 582/2743 - (21%)
• Similarity: 1039/2743 - (37%)
• Gaps: 766/2743 - (27%)

  Fly   151 AIEDI-----------KVPLE--QADMYAKS------LLEVLQHAHHIGYATHGDIFSGSL---- 192
            ||:|:           |||.:  .:..||||      |:..|:.........:..|||.::
Yeast    14 AIKDLNSGVDSKVQIKKVPTDPSSSQEYAKSLKILNTLIRNLKDQRRNNIMKNDTIFSKTVSALA 78

  Fly   193 -----HQALLILKE----------CDMDTKLASLNY--CHNVLRSQSASSWITNPDVGHYAQLTL 240
                 :..||::|:          .|....::.|||  .|.:        |.....:|.:.:..:
Yeast    79 LLLEYNPFLLVMKDSNGNFEIQRLIDDFLNISVLNYDNYHRI--------WFMRRKLGSWCKACV 135

  Fly   241 EATAIMWSAVAKWLDMGCMTRQELKRLNITTKLLLEVL---------HMRARPAHHLGYLLLNEI 296
            |    .:...||:.    :|......:|:..:.|.|||         :...:..:.|.|...:|.
Yeast   136 E----FYGKPAKFQ----LTAHFENTMNLYEQALTEVLLGKTELLKFYDTLKGLYILLYWFTSEY 192

  Fly   297 LSLPTAIE-LDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHCHPTHLVPILALMGLKQ 360
            .:...:|. ||..|..|...:          ..::|:.:...:..  .|.         |..|:.
Yeast   193 STFGNSIAFLDSSLGFTKFDF----------NFQRLIRIVLYVFD--SCE---------LAALEY 236

  Fly   361 TEMRSGVVQVLTQSLV--EILKKEEVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEGHIDS 423
            .|     :|:...|||  .:..:....:.|...|:..    :|| |.:|:...|.:....|.:|:
Yeast   237 AE-----IQLKYISLVVDYVCNRTISTALDAPALVCC----EQL-KFVLTTMHHFLDNKYGLLDN 291

  Fly   424 SVLAMLPLQCE-IIKVADTNWNNLSMQLVELESKCSADRRHIHLEICSLLMQITFIRHFLKTQTQ 487
            .     |...: |:::       .|:.:....|||..|  |..::..:...|   ..||..||..
Yeast   292 D-----PTMAKGILRL-------YSLCISNDFSKCFVD--HFPIDQWADFSQ---SEHFPFTQLT 339

  Fly   488 HQLLAILQRHLKLSYLCAIRLETPSSVHTQMQSFYAQQY-MRLFQSEETQEIFCSNLPQLYISGF 551
            ::.|:|:...||...|....|:            |..:: :.::|||
Yeast   340 NKALSIVYFDLKRRSLPVEALK------------YDNKFNIWVYQSE------------------ 374

  Fly   552 IKPEQLMKALPT-INNRSGRAQVIRLLLCSQPGKLSVFKVKDRIELYCPKCRPLPKKLPGIYLGK 615
              |:..:|.:.: .::|..:.:.:|||:      |..|...:|..|...:...|.   ||.:
Yeast   375 --PDSSLKNVTSPFDDRYKQLEKLRLLV------LKKFNKTERGTLLKYRVNQLS---PGFF--- 425

  Fly   616 CKQQLPCPDFSSTNLEMIANDLLFYPDFECIAQHLDL---LCFEPN---------VILGLLRETE 668
                           :...|      ||:.|.....:   .||:.|         ||||.|...|
Yeast   426 ---------------QRAGN------DFKLILNEASVSIQTCFKTNNITRLTSWTVILGRLACLE 469

  Fly   669 ALQKVSVKVIGQLVSAMR--------------------VR-SP---------------------- 690
                 |.|..|.|.::.:                    || :|
Yeast   470 -----SEKFSGTLPNSTKDMDNWYVCHLCDIEKTGNPFVRINPNRPEAAGKSEIFRILHSNFLSH 529

  Fly   691 ----EFLEQLANLVLAAIKAMLA--KP--LTEQN-------VLQQRSMLN-------VLTAI--- 730
                ||.|.|.:.:|.::..:.:  :|  ||:.|       .|.|:..:|       :.|.|
Yeast   530 PNIDEFSESLLSGILFSLHRIFSHFQPPKLTDGNGQINKSFKLVQKCFMNSNRYLRLLSTRIIPL 594

  Fly   731 -----AHMEDNEIWLFHWFKMTFFFLVHTRSLVAQEAVLAATEMCASQGLQTIHLWNWYKRDALD 790
                 :|..::|    |...:..|.......:|.:..|:|.|::..:.           ..|..|
Yeast   595 FNISDSHNSEDE----HTATLIKFLQSQKLPVVKENLVIAWTQLTLTT-----------SNDVFD 644

  Fly   791 LTVRLALNVYLLDG----VRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMVLPHCIVNPLCKGV 851
            ..:...::::..|.    :..|..::.:.|:|..|                  |:.:::|:...:
Yeast   645 TLLLKLIDIFNSDDYSLRIMMTLQIKNMAKILKKT------------------PYQLLSPILPVL 691

  Fly   852 LVLIAKQM-QKHIG-------------TLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSL 902
            |..:.|.: ::.:|             |:..|....|..:..:..:.::.:...:::.....|.:
Yeast   692 LRQLGKNLVERKVGFQNLIELLGYSSKTILDIFQRYIIPYAIIQYKSDVLSEIAKIMCDGDTSLI 756

  Fly   903 QQ----LMNADVKQTVAELLI-------------YFNRNPTF-------VMRSFQSLLQLSIGSL 943
            .|    |:..:.:|..|..|:             :.||.|||       .:..:::|.:::....
Yeast   757 NQMKVNLLKKNSRQIFAVALVKHGLFSLDILETLFLNRAPTFDKGYITAYLPDYKTLAEITKLYK 821

  Fly   944 EELSSQTANAEFANFI--AERFLGVITYFESCL---------------SEPSFEKPLKEETLYSL 991
            ..::...:::|.||.|  :.|||  ||.||...               .|.:|:|.|::..   |
Yeast   822 NSVTKDASDSENANMILCSLRFL--ITNFEKDKRHGSKYKNINNWTDDQEQAFQKKLQDNI---L 881

  Fly   992 GQIMRFVGSQHVTQFR------FKIIAMLSFVHTLQEPRLQ--------RICL------------ 1030
            |....|....|..:.|      .::|..:||: .:..|:..        .|||
Yeast   882 GIFQVFSSDIHDVEGRTTYYEKLRVINGISFL-IIYAPKKSIISALAQISICLQTGLGLKEVRYE 945

  Fly  1031 --KIWHIFLHVVNVQELGPSLGRIVATLQPLLAD-------------NESVKQVNDL------YE 1074
              :.||:.:..:|.:||...:..::|.:....::             :..:|:.:||      |.
Yeast   946 AFRCWHLLVRHLNDEELSTVIDSLIAFILQKWSEFNGKLRNIVYSILDTLIKEKSDLILKLKPYT 1010

  Fly  1075 FIILRNASMLGTFITDLYFLDRMENVSPSIQKCIRRHTAHLDLKGLAEEENQSPPLVDQLRFLQK 1139
            .:.|.....||....|..|. ||.|.       ||..|   ||         .|...:.|:...|
Yeast  1011 TLALVGKPELGILARDGQFA-RMVNK-------IRSTT---DL---------IPIFANNLKSSNK 1055

  Fly  1140 HITDECL-QVRVYALQHLGDLFGRRR----------PKLNSTILSELPLEPMLE---QIVNVLMA 1190
            ::.::.| .:.||.         ||:          .|:..|....|.|..:|:   :..|:
Yeast  1056 YVINQNLDDIEVYL---------RRKQTERSIDFTPKKVGQTSDITLVLGALLDTSHKFRNL--- 1108

  Fly  1191 GCQHDDSQLQMASAKCLGELGAIDAS---YLPSNYNFASPQHLPLNILSDDFAVLALTSLCRGYQ 1252
                 |..|....|||:..:|.:|.:   :..:.|:......|..::.:..|.:..:..:.....
Yeast  1109 -----DKDLCEKCAKCISMIGVLDVTKHEFKRTTYSENEVYDLNDSVQTIKFLIWVINDILVPAF 1168

  Fly  1253 FQQNTKHVDSF-SLAIQETLAICGIS------------PKEQKKVQLWQSLPARMRQLMEPMLHS 1304
            :|........| :|.|||:|..||:|            |.|.|   ||:...:..:..:.|:|.|
Yeast  1169 WQSENPSKQLFVALVIQESLKYCGLSSESWDMNHKELYPNEAK---LWEKFNSVSKTTIYPLLSS 1230

  Fly  1305 CYTCVHRPSTCLQQ------PLFGSHYSHNYYEEWAFLWASRL-IDYLPS-SGRRHLLSSYKPCI 1361
            .|         |.|      ||   .|..|.::|...:|..|. :|.|.: :...|.|..:...|
Yeast  1231 LY---------LAQSWKEYVPL---KYPSNNFKEGYKIWVKRFTLDLLKTGTTENHPLHVFSSLI 1283

  Fly  1362 KRDSNMLSTF-YPYILLHALLECT-----TEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKE 1420
            :.|...||.| .|||.|..:::..     .:..|.|..||.::...|.|..:::: ...|....|
Yeast  1284 REDDGSLSNFLLPYISLDIIIKAEKGTPYADILNGIIIEFDSIFTCNLEGMNNLQ-VDSLRMCYE 1347

  Fly  1421 NAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGG 1485
            :.|:.||                                       :.::|..|:::.:.:..|.
Yeast  1348 SIFRVFE---------------------------------------YCKKWATEFKQNYSKLHGT 1373

  Fly  1486 ---KPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLES-YLEEGEDKSQ--RLLEQ 1544
               |..:|.:...| |.|||...|..|:::.|.....:.|:..|||. |.:...||:|  :||:.
Yeast  1374 FIIKDTKTTNMLLR-IDEFLRTTPSDLLAQRSLETDSFERSALYLEQCYRQNPHDKNQNGQLLKN 1437

  Fly  1545 FTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHV 1609
            .....|..|   |.||::|.::      :.....||:::.|.|          .|...::..|..
Yeast  1438 LQITYEEIG---DIDSLDGVLR------TFATGNLVSKIEELQ----------YSENWKLAQDCF 1483

  Fly  1610 RAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQCSQ 1674
            ..:  ....|.|||..       :.|...|..|.::                 ::.||.....|.
Yeast  1484 NVL--GKFSDDPKTTT-------RMLKSMYDHQLYS-----------------QIISNSSFHSSD 1522

  Fly  1675 GCLKLRRPLTTRIEFDSL------LDGMRESV------LEELRSC---SAVQQHSYANAYDAV-- 1722
            |.:.|...:.   |:.|:      |:|..:::      :|.||:.   ..:.|::.|.|..|:
Yeast  1523 GKISLSPDVK---EWYSIGLEAANLEGNVQTLKNWVEQIESLRNIDDREVLLQYNIAKALIAISN 1584

  Fly  1723 -------------------------------------LKLHLVHELHCSQELVEKLEQDRDEDNQ 1750
                                                 :|||.:::|.......:|.|.   :.|.
Yeast  1585 EDPLRTQKYIHNSFRLIGTNFITSSKETTLLKKQNLLMKLHSLYDLSFLSSAKDKFEY---KSNT 1646

  Fly  1751 EKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSA 1815
            ..|        .||::.:.........|.|.|::.         |:..:......:|.:.:...|
Yeast  1647 TIL--------DYRMERIGADFVPNHYILSMRKSF---------DQLKMNEQADADLGKTFFTLA 1694

  Fly  1816 QINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQ 1880
            |:.||..:|..|...::...|.:.....:|.|::||::|:...|:..::|.....:.....|.:.
Yeast  1695 QLARNNARLDIASESLMHCLERRLPQAELEFAEILWKQGENDRALKIVQEIHEKYQENSSVNARD 1759

  Fly  1881 LAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQG 1945
            .||.   |....::|..     |.:..::.::|.:|:...:..:.:..:..:..:..::||.::.
Yeast  1760 RAAV---LLKFTEWLDL-----SNNSASEQIIKQYQDIFQIDSKWDKPYYSIGLYYSRLLERKKA 1816

  Fly  1946 GKSEPTGEQDDMLINVMV-----NYAKSLRYGSEHVYQSMPRLISLWLDTTESSTN--------- 1996
            ......|..:...|:..:     |.||        |.:::|::|:.|||...:|.:
Yeast  1817 EGYITNGRFEYRAISYFLLAFEKNTAK--------VRENLPKVITFWLDIAAASISEAPGNRKEM 1873

  Fly  1997 ----TEQV-KKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQS 2056
                ||.: ..:.:.|.:|    ||.::|.|.:|:||||.|.......::.::::.|...||...
Yeast  1874 LSKATEDICSHVEEALQHC----PTYIWYFVLTQLLSRLLHSHQSSAQIIMHILLSLAVEYPSHI 1934

  Fly  2057 LWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVTLDRTYKLSD 2121
            ||.:.....|..:.|:.|.|.:|...| |:|      |:.:.|....:||| |.:|......:..
Yeast  1935 LWYITALVNSNSSKRVLRGKHILEKYR-QHS------QNPHDLVSSALDLT-KALTRVCLQDVKS 1991

  Fly  2122 LDTRLSK-LCKQPEF------SQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQI 2179
            :.:|..| |.|..:|      |.:::|..|.:....||  :|||..|           :.|::.:
Yeast  1992 ITSRSGKSLEKDFKFDMNVAPSAMVVPVRKNLDIISPL--ESNSMRG-----------YQPFRPV 2043

  Fly  2180 Y-ISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPA 2243
            . |..|..|..:..|..|||:|.|..|||..|.::.| |:|:|:|.:.|:|...:...|.:|..:
Yeast  2044 VSIIRFGSSYKVFSSLKKPKQLNIIGSDGNIYGIMCK-KEDVRQDNQYMQFATTMDFLLSKDIAS 2107

  Fly  2244 RQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERK 2308
            |:|.|.|..|:||...|:||::|.:||:.:.|||....|...::..|.:.|....  .|.:::.|
Yeast  2108 RKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLKIKYSLKSLHDRW--QHTAVDGK 2170

  Fly  2309 REVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAE 2373
            .|.:.:| |...||:..:|..:.|..|.:|:.|||||.|:.|||:|||:||||||||.||||...
Yeast  2171 LEFYMEQ-VDKFPPILYQWFLENFPDPINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDI 2234

  Fly  2374 GNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTL 2438
            ..|..:||||:|||.:|:.||.||:||||||.|::.|:|.:|.||:|:|..|:||.|:::....|
Yeast  2235 QTGKVLHVDFDCLFEKGKRLPVPEIVPFRLTPNLLDALGIIGTEGTFKKSSEVTLALMRKNEVAL 2299

  Fly  2439 MSILRPFVYDVGAQTRKGAATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKV 2503
            |:::...:||....       ..|.|.::.:.::::| :..|  :.:.||..||...||.|||..
Yeast  2300 MNVIETIMYDRNMD-------HSIQKALKVLRNKIRG-IDPQ--DGLVLSVAGQTETLIQEATSE 2354

  Fly  2504 DNLASMYIGWGAF 2516
            |||:.|||||..|
Yeast  2355 DNLSKMYIGWLPF 2367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	32/149 (21%)
		FAT	1653..1985	CDD:280429	62/390 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	109/266 (41%)
		FATC	2486..2517	CDD:280430	18/31 (58%)
MEC1	NP_009694.3	TEL1	194..2368	CDD:227365	545/2547 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I585
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	361	1.000	Inparanoid score	I382
Isobase	1	0.950	-	0.85977	Normalized mean entropy	S4341
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004409
OrthoInspector	1	1.000	-	-		oto99135
orthoMCL	1	0.900	-	-		OOG6_102609
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2044
SonicParanoid	1	1.000	-	-		X3128
TreeFam	1	0.960	-	-
	13	12.800