DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and STT4

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_013408.1 Gene:STT4 / 851014 SGDID:S000004296 Length:1900 Species:Saccharomyces cerevisiae


Alignment Length:2145 Identity:392/2145 - (18%)
Similarity:677/2145 - (31%) Gaps:760/2145 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   805 VRFTRSLRALT----KMLGFTCVQEFTCKYHRLLTAMVLPHCIVNPLCKGVLVLIAKQMQKHIGT 865
            :||||.|:|.:    |.:|         :..:|.|.                   |...|...||
Yeast     1 MRFTRGLKASSSLRAKAIG---------RLTKLSTG-------------------APNDQNSNGT 37

  Fly   866 -----------LFSISFLRIYT-HVFLTEEPELANSCIELVVSCTQSSLQQLMNADVKQTVAELL 918
                       .:|.:..:||| .:.|:|...|.:.|:.:..:.      .|:...:|:.:|.  
Yeast    38 TLDLITHTLPIFYSTNTSKIYTIPLTLSEWEVLTSLCVAIPTTL------DLVETMLKEIIAP-- 94

  Fly   919 IYFNRNP----------TFVMRSFQSLLQLSIGSLEELSSQTANAEFANFIAERFLGVI-TYFES 972
             ||...|          .|.:...::.::|....|.:...|.  .|....:.|...|:| ||||.
Yeast    95 -YFLETPRQRISDVLSSKFKLEQMRNPIELLTFQLTKFMIQA--CEQYPVLYENIGGIISTYFER 156

  Fly   973 CLSEPSFEKPLKEETLYSL----GQIMRFVGSQHVTQFRFKIIAML----SFVHTLQE------- 1022
            .|...:    :|:..|.||    ...::|..|..:|:|.:|.:|.|    ||::.:.:       
Yeast   157 VLKIFT----IKQSGLLSLVGFINAFIQFPNSTELTKFTWKKLAKLVLRGSFLNEVDKILNSSAT 217

  Fly  1023 -------------------------PRLQRICLKIWHIFLHVVNVQELGPSLGRIVATL------ 1056
                                     .|||      ..:..|::|...:|.:|...:...      
Yeast   218 FTNDSIVQYYDAGNELSSAYLLELISRLQ------VSLISHLLNTSHVGANLSEFLLNQQYQFYK 276

  Fly  1057 --QPLLADNESVKQVNDLYEFIILRNASMLGTFITDLYFLDRMENVSPSIQKCIRRHTAHLDLKG 1119
              |.:..:|:..|.::|.: |.:..|..    |.||:..:        |:|.|...|...|....
Yeast   277 FDQEVADENDDTKCIDDFF-FNVRSNKQ----FFTDMCKI--------SLQFCSESHILDLSTDN 328

  Fly  1120 LAE-------------------EENQS----------PPLVDQLRFLQKHITDECLQVRVYALQH 1155
            .|.                   |:.:|          ...:|:. ||...:|...::. :.|...
Yeast   329 RARFSFDTRAHYLQTLCLIPFIEDTESELFESFTNVVSESIDKF-FLSDVVTPSLIKA-IVASAS 391

  Fly  1156 LGDLFGRRRPKLNSTILSELP-----------------------LEPMLEQIV-------NVLMA 1190
            |.:.|   ..||:.|::...|                       |.|:.|..:       |.|:|
Yeast   392 LLNFF---TEKLSLTLIRMFPLLVASPHITTETVNDVAKIFTTGLYPLNEDAIVSTIYSMNNLLA 453

  Fly  1191 GCQHDDS--------QLQMASAK--------------------------CLGELGAID------- 1214
             ...|.|        ||.:.|.|                          .:|:|.:.|       
Yeast   454 -VSEDGSPVPVLRERQLTITSGKNIEKDYFPLRNSSASLDGTGALLGNTTVGQLSSHDVNSGATM 517

  Fly  1215 -------------ASYLPSNYNFASPQHLPLNIL-------SDDFAVLALTSLCRGYQFQQNTKH 1259
                         .:.:.|.||..|...|.::||       |.:...:.|.||.|   ...||. 
Yeast   518 TYHASLISNCVAATTTIASYYNTQSITALTISILTQKVNSMSKELDGVILNSLAR---LAPNTS- 578

  Fly  1260 VDSFSLAIQETLAICGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPSTCLQQPLFGSH 1324
            :..|||.::...:...|:.|......|...:.|:              ||      :.:.|...|
Yeast   579 LTEFSLLLKFFKSRTVIATKIDDSALLKNIIKAK--------------CV------ISKELLARH 623

  Fly  1325 YSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKPC--IKRDSNMLSTFY-PYILLHALL----- 1381
            :|.:.|    |::...|:|.:.:||....|..::|.  |.|.::.::|:. |   |.|||     
Yeast   624 FSSDLY----FMYLHDLLDSIIASGEVERLEHHRPQTEISRVADQIATYLEP---LAALLPVPGD 681

  Fly  1382 --------ECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPL 1438
                    |.||.:..:....|:            :.|....|.|.:..|....:..|.:  .||
Yeast   682 TPLDINKDEVTTNKFRNAWFNFV------------IHGYHLGGPIVKRNFSFLLTIAYNS--PPL 732

  Fly  1439 ASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSNYRKIHEFL- 1502
            ||...::.||           |..|:...|:|              |...|.|....::|.|:. 
Yeast   733 ASEFPANNKE-----------LSLEMNTILRR--------------GSSNENIKQQKQQITEYFN 772

  Fly  1503 -NLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQ 1566
             |::.....|.:..   .:..|...||:...|..|.|:.||         |.|  ||..:.|:::
Yeast   773 TNIVQYRTTSSSKI---MFLAAAVLLETIRCEAGDCSKTLL---------YFS--DPSILSGSIE 823

  Fly  1567 VRSYDMSVTQDILVNRLVERQQDMITSYEQL----------LSSTDQMQPDHVRAMIDAYLRDTP 1621
            .....:||:......||:::..|.|.:.:.:          ||..:....|......:.::|..|
Yeast   824 KCIAVLSVSMIRKYARLIQKGNDAIFNSKMIAQQLNNLLLCLSHREPTLQDAAFHACEIFIRSIP 888

  Fly  1622 KTA-----------------QLIADGLWQRLSDRYSDQCFAECKSELL------WRLGSYDEMEE 1663
            .:.                 ..|.|....:...||..: ....|:.:|      ||..:...:.:
Yeast   889 SSLCHHLSLYTLLDMLTALFDSILDSEAHKFEPRYEFK-LKHSKTTILVPSSSSWRATTLSRLHK 952

  Fly  1664 LQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYA------------ 1716
            ....|.           |.|..|...|:.:  :.:|.:.:|...|.:....:.            
Yeast   953 SAKEWV-----------RILLNRSNQDTKI--LLQSYISDLGEYSRLNSVEFGVSFAMDMAGLIL 1004

  Fly  1717 -----------------NAYDAVLKLHLVHELHCSQELVEKLEQDRDED---NQEKLMKNY---- 1757
                             |.....:.||.....:.....:....:|....   :.:.:.||.    
Yeast  1005 PADKELSRLTYYGPEKPNTISGFISLHSWRSKYLFDTAITSSPEDIKRQIGISTQNIRKNLTLGN 1069

  Fly  1758 ---------FDDWQYRLQIV---QPQVRIQESIY-----------SFRRNILAELQRRLTDRNHL 1799
                     |.|....|.|:   .|...|.:.::           ....|:...:   :|::..:
Yeast  1070 KIITKDVTDFLDMATALLILGNGAPASLIYDIVHIPFEVFTSASLKIATNVWLTI---ITEKPEV 1131

  Fly  1800 LPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLE 1864
            ...|..|:...|:.|  |:.|.|...|.  :.||..|||         |:.:...|         
Yeast  1132 AHLLLVEVCYCWMRS--IDDNIGLYSRD--HDLKGEEYQ---------KMEYSPYD--------- 1174

  Fly  1865 EQLSIMRSGCQGNVKQLA-AEQRHL--------FFRGKYLQAVYSAESMHLCADAVLKYFQEAIA 1920
                  ::|...:.|..: |.|.||        .|.|...|:.:..:....||...:|...:| :
Yeast  1175 ------KAGINRDAKNASQAMQPHLHVIKFFASHFEGTLFQSDFLLKIFTKCALYGIKNLYKA-S 1232

  Fly  1921 VHRQSESCHVQMAQFLEKILEA--RQGGK---------------------SEPTGEQD-----DM 1957
            :|..:.....::..|...:|.|  :||.|                     :.|.|..:     |:
Yeast  1233 LHPFARMIRHELLLFATLVLNASYKQGSKYMGRLSQEITNGALSWFKRPVAWPFGSNELKIKADL 1297

  Fly  1958 LIN----VMVNYAKSLRYGSEHVYQSMPRL----------ISLWLDTTE------SSTNTEQV-- 2000
            .:.    :.:|...||.  |.|..:....|          |..||..||      |:..|..:  
Yeast  1298 SVTRDLFLQLNKLSSLM--SRHCGKDYKILNYFLASEIQQIQTWLTPTEKIEGADSNELTSDIVE 1360

  Fly  2001 -------------------KKMNDLLTN-------CCTALPTAVFYTVYSQMLSRLCHPVNDVFT 2039
                               ||..|:|..       .|...|:|:...:....||    ...|:..
Yeast  1361 ATFAKDPTLAINLLQRCYSKKAEDVLVGLVAKHALMCVGSPSALDLFIKGSHLS----SKKDLHA 1421

  Fly  2040 VLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTF-------QKLLQDFN 2097
            .|....:.     |.:|:.:.||.::....  |.:..:...:|:..|..|       |.|..|..
Yeast  1422 TLYWAPVS-----PLKSINLFLPEWQGNSF--ILQFSIYSLESQDVNLAFFYVPQIVQCLRYDKT 1479

  Fly  2098 SLTERLMDLTNKEVTLDRTYKLSDLDTR------LSKLCKQPEFSQILLPFEKYMQPTLPLNSDS 2156
            ...|||:        || |.|:|.|.:.      |:...|..|..|     |..::|||....:.
Yeast  1480 GYVERLI--------LD-TAKISVLFSHQIIWNMLANCYKDDEGIQ-----EDEIKPTLDRIRER 1530

  Fly  2157 --NSSEGSHLPANQSTVNWF-----------PY----------------------QQIYISGFQE 2186
              :|...||....:....:|           ||                      ..:|:....:
Yeast  1531 MVSSFSQSHRDFYEREFEFFDEVTGISGKLKPYIKKSKAEKKHKIDEEMSKIEVKPDVYLPSNPD 1595

  Fly  2187 SVLI---------LRSAAK-PKKLTIRCS-------DGKDYDV------LVKPKDDLRRDARLME 2228
            .|:|         |:|.|| |...|.:..       .||:.:|      :.|..||.|:|...::
Yeast  1596 GVVIDIDRKSGKPLQSHAKAPFMATFKIKKDVKDPLTGKNKEVEKWQAAIFKVGDDCRQDVLALQ 1660

  Fly  2229 FNGLVKRY---LHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMS 2290
            ...|.:..   :..|       :::..|.|......||:::.|||     |:..::..:      
Yeast  1661 LISLFRTIWSSIGLD-------VYVFPYRVTATAPGCGVIDVLPN-----SVSRDMLGR------ 1707

  Fly  2291 TRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMV 2355
                        |::....|.||.:........||              .|||.:::::|..|::
Yeast  1708 ------------EAVNGLYEYFTSKFGNESTIEFQ--------------NARNNFVKSLAGYSVI 1746

  Fly  2356 GYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYP---EVVPFRLTHNMIVAMGPLGVE 2417
            .|:|...|||..||:: :..|..:|:||..:|   :::|..   |.|||:||..|:..||     
Yeast  1747 SYLLQFKDRHNGNIMY-DDQGHCLHIDFGFIF---DIVPGGIKFEAVPFKLTKEMVKVMG----- 1802

  Fly  2418 GS--------FRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQRIADRLQ 2474
            ||        |.:.|.......:...:.::..:.|.:       ..|....|..|.::.:..|.|
Yeast  1803 GSPQTPAYLDFEELCIKAYLAARPHVEAIIECVNPML-------GSGLPCFKGHKTIRNLRARFQ 1860

  Fly  2475  2474
            Yeast  1861  1860

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 29/153 (19%)
FAT 1653..1985 CDD:280429 68/441 (15%)
PIKKc_ATR 2181..2448 CDD:270625 64/303 (21%)
FATC 2486..2517 CDD:280430
STT4NP_013408.1 TEL1 1..1900 CDD:227365 392/2145 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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