DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and ATR

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	NP_001332644.1	Gene:	ATR / 834082	AraportID:	AT5G40820	Length:	2703	Species:	Arabidopsis thaliana

Alignment Length:	2805	Identity:	657/2805 - (23%)
Similarity:	1082/2805 - (38%)	Gaps:	788/2805 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ILSSCCSNHPKL-FERLVLAYVEAIEETHLQLSSLDLGQLSNERKPAIT---VRIFRCDVECLQE 145
            :.|||.....|| .|.|||....|::.|.           |.|.|.::.   |||.:....|:.:
plant   307 VYSSCSDAAVKLTAESLVLVLSHALQRTK-----------SEELKASLCSAYVRIVKSCPPCIWK 360

  Fly   146 FDPHCAIEDIKVP---LEQADMYAKSLLEVL-------------QHAH----------HIGYATH 184
            .  ||.:|.:.:|   .:..:.: |::|.||             .|..          :.|...|
plant   361 I--HCLLELLHLPEPCFQLIECF-KAVLIVLGPGCVRVETTKCGSHTSATSDRPVQGINAGKKRH 422

  Fly   185 ---------------GDIFSG-----------------SLHQALLILKE-----------CDMDT 206
                           .||..|                 ||.:.|:...|           ...::
plant   423 IEDESTYKRKRQKVGDDIRRGVYFAPEFADETDGKDAASLREMLISTVESLKPPPAGPSLSQTES 487

  Fly   207 KLASLN-------YC------HNVLRSQSASSWI---------TNP---DVGHYAQ-----LTLE 241
            .:.:|:       :|      |.:.....|  ||         |||   |:..|.:     |.:.
plant   488 SIVALSMLTNAFCFCPWTDMTHRLFNQMYA--WIPWIAGQVEETNPIMFDISIYLEGIHNLLLVA 550

  Fly   242 ATAIMWSAVAKWLDMGCMTRQELKRLNITTKLLLEVLHMRARPAHHLGYLLLNEILSLP--TAIE 304
            .....:...:|..|:  :..|.|.:|..|..:|.:.      |:.    |:.::.||:.  |.:.
plant   551 GVDPQYEYTSKGNDL--VAIQFLLKLPWTHYMLFKT------PSS----LVKSKCLSVGIWTKLG 603

  Fly   305 LDDGL-------------------------LETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHC 344
            |.||.                         |:.|.|.: |.|.|....||.|:..::||:.  ..
plant   604 LQDGSDFDIFSWSLSDDFEQVQAVAAISMPLKVLFSGL-GALLHMFPKLEHLLEEKELMIK--KA 665

  Fly   345 HPTHLVPILALMGLKQTEMRSGVVQVLTQSLVEILKKEEVLSKDWQKLIAILRGFKQLEKLILSQ 409
            .|..|..:..|.|...|:.......:|   |.|.|||:|.|:       ::|:||:
plant   666 IPQSLGFLSCLYGSSTTDSEKTACHLL---LHEDLKKDETLN-------SLLQGFR--------- 711

  Fly   410 SQHKIAEHEGHIDSSVLAMLPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIHLEICSLLMQ 474
                                   |                     |||.
plant   712 -----------------------C---------------------SKCD---------------- 716

  Fly   475 ITFIRHFLKTQTQHQLLAILQRHLKLSYLCAIRLETPSSVHTQM---------QSFYAQQYMRLF 530
                 .|::.:.        ::|.::       :|||..|..:|         ||.|   :..|:
plant   717 -----KFIERED--------EKHFRI-------IETPEMVKLKMDHHRDYFNLQSLY---FNLLY 758

  Fly   531 --QSEETQEIFCSNLPQLYISGFIKPEQLMKALPTINNRSGRAQVIRLLLCSQPGKLSVFKVKDR 593
              .||||| :.|..:.: .|.|...|:.|::.         |:|.||   |.|  .|.|....|.
plant   759 DESSEETQ-LACVEVIR-RILGHTSPDILVRT---------RSQWIR---CLQ--YLLVHVNTDV 807

  Fly   594 IELYCPKCRPLPKKLPGIYLGKCKQQLP---CPDFSSTNLEMIANDLLFYPDFECIAQHLDLLCF 655
            .|.:|.:.        ||::     |.|   |...|....|.......|......:|...|||
plant   808 REAFCAQI--------GIFV-----QHPIVSCLFLSEDATEKSCERNFFNLIEHSLAAAKDLL-- 857

  Fly   656 EPNVILGLLRETEALQKVSVKVIGQLVSAMRVRSPEFL-------EQL--ANLVLAAIKAMLAKP 711
                ::..|.||.|...|:|.|..:|          ||       :||  .||:   ::...:|.
plant   858 ----VIQTLLETTAEVMVAVDVTSEL----------FLICLFLLIDQLDHPNLI---VRINASKL 905

  Fly   712 LTEQNVLQQRSMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQ--EAVLAATEMCASQG 774
            :.....:..:.....|.:.|....||:     |......|....::|.:  ||||         |
plant   906 INRSCYIHVKGGFATLLSTASHIQNEL-----FDNLSVRLTSRPNVVREFAEAVL---------G 956

  Fly   775 LQTIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMVL 839
            ::|..|..     .:...|...|.||..:..:...:|..|.|                |:...|:
plant   957 VETEELVR-----KMVPAVLPKLLVYWQENAQAANTLNELAK----------------LIDTDVV 1000

  Fly   840 PHCIVNPLCKGVLVLIAKQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSLQQ 904
            | .|||.|.:.:...:.::..|::     :|.|::|       ..::.:...|:..:...:.|.:
plant  1001 P-LIVNWLPRVLAFALNQEEDKNL-----LSVLQLY-------HSQIGSDNQEIFAAALPALLDE 1052

  Fly   905 LM----NADVKQTVAELLIYFNRNPTFVMRSFQSLLQLSIGSLEELSSQTANAE-FANFIAERFL 964
            |:    .||..:|...|    .|.|               .:::::|....||| ...|:...|:
plant  1053 LVCFVDIADTPETDRRL----QRLP---------------DAIKKISKVLTNAEDLPGFLQNHFV 1098

  Fly   965 GVITYFESCL--SEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEPRLQR 1027
            |::...:..:  ::..|   |:::.|..:..::..:| .:::.:..|::.:|  :|.:::..||.
plant  1099 GLLNSIDRKMLHADDIF---LQKQALKRIKLLIEMMG-HYLSTYVPKLMVLL--MHAIEKDALQS 1157

  Fly  1028 ICLKIWHIFLHVVNVQELGPS-----LGRIVATLQPLLADNES-----VKQVNDLYEFIILRNAS 1082
            ..|.:.|.|..  .:.::.||     :.:|.|.|.|.|...:.     :.:|..:.|.::|:|..
plant  1158 EGLLVLHFFTR--KLADVSPSSIKYVISQIFAALIPFLEKEKEGPHVYLDEVVKILEELVLKNRD 1220

  Fly  1083 MLGTFITDLYFLDRMENVSPSIQKCIRRHTAHLDLKGLAEEENQSPPLVDQLRFLQKHITDECLQ 1147
            ::...|.:...|       |||......:.|..:.:||..       |.||||.:...:..|.|.
plant  1221 IVKEHICEFPLL-------PSIPSLGELNNAIQEARGLMS-------LKDQLRDIVNGMKHENLN 1271

  Fly  1148 VRVYALQHLGDLFGRRRPKLNSTILSELPLE-PMLEQIVNVLMAGCQHDD-----SQLQMASAKC 1206
            ||......|..|...|...:.:.|..||..: .:|..::..|:.||..:.     .:|::..|.|
plant  1272 VRYMVACELSKLLYNRNEDVAALIAGELVSDMEILSSLITYLLQGCAEESRTTVGQRLKLVCADC 1336

  Fly  1207 LGELGAIDASYLPSNYNFASPQHLPLNILSDDFAV-LALTSLCRGYQFQQNTKHVDSFSLAIQET 1270
            ||.:||||    |:....||.....:....||... |....|.|.::..|:|...||.:|||||.
plant  1337 LGAIGAID----PAKVRVASCSRFKIQCSDDDLIFELIHKHLARAFRAAQDTIIQDSAALAIQEL 1397

  Fly  1271 LAICG-----------ISPKEQKKV-------------------QLWQSLPARMRQLMEPMLHSC 1305
            |.|.|           ::|:|..:|                   :||......:::|:.|.|.|.
plant  1398 LKIAGCEPSLAGNVVVLTPQEHVQVNVSGSRRCGGNNEVKDRGQKLWDRFSNYVKELIAPCLTSR 1462

  Fly  1306 YTC-----------VHRPSTCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKP 1359
            :..           ::|||..              :..|...|..:|..:...| |..:.::.:.
plant  1463 FQLPNVSDPGSAGPIYRPSMS--------------FRRWLSYWIRKLTAFATGS-RVSIFAACRG 1512

  Fly  1360 CIKRDSNMLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENAFK 1424
            .::.|....:...||::|..:...|...|..|.||.::||.|....:|.|         ..|:|.
plant  1513 IVRHDMQTATYLLPYLVLDVVCHGTEAARLSISEEILSVLDAAASENSGV---------TINSFG 1568

  Fly  1425 QFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAE----LLDFLQRWLRE----------W 1475
            ..:|                              ::|.:    |||.|.:|:.:          .
plant  1569 VGQS------------------------------EVCVQAVFTLLDNLGQWVDDVKQGVALSSSL 1603

  Fly  1476 QRIHGRSTGGKPPETIDSN----------YRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESY 1530
            |...||....|..:.:.::          .:.:.|.|..|||:.::|||:.|..|||:|.||||:
plant  1604 QSSGGRQVAPKSKDQVSNSTTEQDHLLVQCKYVLELLLAIPKVTLARASFRCQAYARSLMYLESH 1668

  Fly  1531 LEEGEDKSQRLLEQFTFLVE---------VYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVER 1586
            : .|:..|.....:.|.:.|         :|..|.:||.:.|...: |..:::...:|:|:....
plant  1669 V-RGKSGSLNPAAEKTGIFENADVSSLMGIYSCLDEPDGLSGFASL-SKSLNLQDQLLINKKSGN 1731

  Fly  1587 QQDMITSYEQLLSSTDQMQP-------DHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCF 1644
            ..|:.|:.||.|    ||:|       |.:..:::.....|..|.   .|||..|:.:.....|.
plant  1732 WADVFTACEQAL----QMEPTSVQRHSDVLNCLLNMCHHQTMVTH---VDGLISRVPEYKKTWCT 1789

  Fly  1645 AECKSELLWRLGSYDEMEEL------------QSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMR 1697
            ...::  .||||.:|.|:|.            .|:..|...:...|:...:..:.:: |:.:|:.
plant  1790 QGVQA--AWRLGKWDLMDEYLDGADAEGLLFSSSDSNASFDRDVAKILHAMMKKDQY-SVAEGIA 1851

  Fly  1698 ESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQELV---EKLEQDRDEDNQEKLMKNYFD 1759
            .|....:...:|....||..||..|:||||:.||...|.::   ..||:.....:|  :.....|
plant  1852 ISKQALIAPLAAAGMDSYTRAYPFVVKLHLLRELEDFQAVLNGDSYLEKSFSTSDQ--VFSKAVD 1914

  Fly  1760 DWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQL 1824
            :|:.||:..|..:..:|.:.:|||.:..            ...|..::...||..|::.|.||..
plant  1915 NWENRLRFTQSSLWTREPLLAFRRLVFG------------ASGLGAQVGNCWLQYAKLCRLAGHY 1967

  Fly  1825 QRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGN------------ 1877
            :.|...||:|.......:.:|:|||||.......|:..|::.|..|..|...:
plant  1968 ETAHRAILEAQASGAPNVHMEKAKLLWITKRSDSAIIELQQSLLNMPEGVVDSTVISSINSLLMA 2032

  Fly  1878 --------------------VKQLAAEQRHLFFRGK---------YLQA----VYSAESMHLCAD 1909
                                .|.|....:.:...|:         |.|.    .:.....||.
plant  2033 PPNPEPTVRNTQSFKEKKDVAKTLLLYSKWIHHSGQKQKKDVLNLYTQVKELLPWEKGYFHLA-- 2095

  Fly  1910 AVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQD---DMLINVMVNYAKSLRY 1971
               ||:.|   ::..:..|..:.:.|  ....:::|..|.....:.   |.|...|..|||:|..
plant  2096 ---KYYDE---LYVDARKCQQESSVF--SSAGSKKGSVSSNLSTEKAGWDYLFKGMYFYAKALHS 2152

  Fly  1972 GSEHVYQSMPRLISLWLD-----TTESSTNTEQVK----KMNDLLTNCCTALPTAVFYTVYSQML 2027
            |.::::|::|||::||.|     .|..|...:::|    |:..|:..|...|||..:.||..|::
plant  2153 GHKNLFQALPRLLTLWFDFGTIYKTSGSAGNKELKSTHMKIMSLMRGCLKDLPTYQWLTVLPQLV 2217

  Fly  2028 SRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRL---QNSTF 2089
            ||:||...|...:::|:|..::..:|||.||::....||....|.:....::..:|.   |:...
plant  2218 SRICHQNADTVLMVKNIITSVLHQFPQQGLWIMAAVSKSTVPARREAAAEIIQGARKGFNQSDRG 2282

  Fly  2090 QKLLQDFNSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKLC---KQP---------EFS------ 2136
            ..|...|.|||:..:                       |||   .||         |||
plant  2283 HNLFIQFASLTDHFI-----------------------KLCFHGGQPRSKVINIATEFSALKRMM 2324

  Fly  2137 --QILLPFEKYMQPTLPL----NSDSNSS---EGSHLPANQSTVNWFPYQQIYISGFQESVLILR 2192
              .|::|.::.:..:||.    |::.:|:   .||.||.              |||..:...||.
plant  2325 PLDIIMPIQQSLTISLPAFHMNNNERHSASVFSGSDLPT--------------ISGIADEAEILS 2375

  Fly  2193 SAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLP 2257
            |..:|||:.:..:||.:|..|.|||||||:|||:|||..::.|.|.:...:|:|:|:|||:||.|
plant  2376 SLQRPKKIILLGNDGIEYPFLCKPKDDLRKDARMMEFTAMINRLLSKYPESRRRKLYIRTFAVAP 2440

  Fly  2258 FNEECGLVEWLPNLASYRSICMNLY-------AQRRLVMSTRQLQSLAVPLHESIERKREVFTKQ 2315
            ..|:||||||:|:....|.|..::|       .|:......|.....||      :::.|:...:
plant  2441 LTEDCGLVEWVPHTRGLRHILQDIYISCGKFDRQKTNPQIKRIYDQCAV------KKEYEMLKTK 2499

  Fly  2316 LVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVH 2380
            ::|..||||.:|....|:.|.:|:.:|..|..|.||.||||:|:||||||||||||...:||.||
plant  2500 ILPMFPPVFHKWFLTTFSEPAAWFRSRVAYAHTTAVWSMVGHIVGLGDRHGENILFDSTSGDCVH 2564

  Fly  2381 VDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPF 2445
            |||:|||::|..|..||:||||||.|||..:|..|.||.|.:.|||||.:|:...:||||||..|
plant  2565 VDFSCLFDKGLQLEKPELVPFRLTQNMIDGLGITGYEGIFMRVCEITLTVLRTHRETLMSILETF 2629

  Fly  2446 VYDVGAQTRKGAATAKI-------TKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKV 2503
            ::|...:..|...::.:       .:.:..|..||||.|.     .:||..|||...||.:|..:
plant  2630 IHDPLVEWTKSHKSSGVEVQNPHAQRAISSIEARLQGVVV-----GVPLPVEGQARRLIADAVSL 2689

  Fly  2504 DNLASMYIGW 2513
            :||..|||.|
plant  2690 ENLGKMYIWW 2699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	21/111 (19%)
		FAT	1653..1985	CDD:280429	86/394 (22%)
		PIKKc_ATR	2181..2448	CDD:270625	125/273 (46%)
		FATC	2486..2517	CDD:280430	14/28 (50%)
ATR	NP_001332644.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	230	1.000	Domainoid score	I658
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	532	1.000	Inparanoid score	I279
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80538at2759
OrthoFinder	1	1.000	-	-		FOG0004409
OrthoInspector	1	1.000	-	-		oto2914
orthoMCL	1	0.900	-	-		OOG6_102609
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3128
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830