Protein Alignment mei-41 and ATM

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_001326746.1
• Gene: ATM / 823975
• AraportID: AT3G48190
• Length: 3013
• Species: Arabidopsis thaliana
• Alignment Length: 3199
• Identity: 686/3199 - (21%)
• Similarity: 1118/3199 - (34%)
• Gaps: 990/3199 - (30%)

  Fly     8 MWKLLYNHVNRNVSN---FSGVYSVIEDILCQ------------EPSLI----------SCSLVR 47
            |.|.|:.||:..:||   |...|..|...|.:            ..||:          .|....
plant   116 MAKTLFTHVHDILSNTPSFQSEYGTILRHLLEIKEYRFQMRKRTYSSLVLLYMERAETGFCEKNS 180

  Fly    48 ELHNKFQDTF--LLWLLNKLAKCLSESPDS--SECINLQRKILSSCCSNHPKLFERLVLAYVEAI 108
            ..|::.::.|  :|.|.:.|.....:.||.  .|.:|....|.|| ..:..||..:|    :|.:
plant   181 GQHSQKEEAFRYILTLQSLLENSPGDFPDDLREEIVNGLIHIFSS-VRDEGKLSRKL----IECV 240

  Fly   109 EETHLQLSSLDLGQLSNERKPAITVRIFRCDVECLQEFDPHCAIEDIKVPLEQADMYAKSLLEVL 173
             .|.|.....:||.||.|...|:...:|||   .|...|                   |:|.|:|
plant   241 -NTFLLKDGPNLGSLSLEIHNAVEQFVFRC---WLTTHD-------------------KNLKEIL 282

  Fly   174 QHAHHIGYA------THGDIFSGSLHQALL--ILKECDM--------------DTKLASLNYCHN 216
                 :.|.      |.....|.||.:.||  :.:|.|:              |.||.:|:...|
plant   283 -----VSYGRLQLNLTRDSSESSSLVEQLLDVVTRELDLGSSSSSASWGDTTKDEKLGALSSYQN 342

  Fly   217 VLRSQSASSW------ITNPDVG-------HYAQLTLEATAIMWSAVAKWL---DMGCMTRQELK 265
            .|...:|..:      .:.|.:.       |.|...::|.     ...|||   ..||:.|....
plant   343 SLVELAAHVFYRACVNTSRPSLSEKRARRQHIAMRMVDAL-----TEGKWLWCAAFGCLVRNYCA 402

  Fly   266 RLNITTKL------------LLEVLHMRARPAHHLGYLL-----LNEILSLP-----------TA 302
            |:|:...:            |||...|| |....|.:.|     |:..||||           ::
plant   403 RINMDLLIYWFEAICTNFQRLLEDASMR-RSYDGLLWTLRSLQGLSSGLSLPDITMDISKSSASS 466

  Fly   303 IELDDGLLETLSSYIQGQL---EHSVVPLEQLVHLQQLMLSH-----------W-HCHPTHLVPI 352
            .|||.|.....||.|.|..   ..||:....||.|..::.|:           | |....|:...
plant   467 SELDRGWQSIWSSLIHGLATFSSMSVIVDAVLVLLGSIISSNHITVKILPQEVWDHQLFRHIPSE 531

  Fly   353 LAL---------MGLK-----QTEMRSGVVQVLTQSL---VEILKKEEVLSKDWQKLIAILRGFK 400
            .||         ||.:     ...:|..:::.:...|   |.:...|.::........::..|||
plant   532 PALYFIACYFSRMGCQGNLQDDLHLRRNLLRAVCAPLSWKVRLTLDERMVQLLPAAAFSLCAGFK 596

  Fly   401 ---QLEKLIL-SQSQHKIAEHEGHID---------SSVLAM--------------------LPLQ 432
               .|.|..| :.||..:.|....:|         .||.|:                    |||.
plant   597 VSLPLPKEHLPTPSQWDVCEQIDDVDRERNFGLFECSVEALTRICSNSSKISGCQVPDVVQLPLV 661

  Fly   433 CEIIKVADTNWNNLSMQLVELESK---------CSADRRHIH---------------LEICSLLM 473
            .....:.|.:...||: :.|::.|         |:.....:|               |:.|..|:
plant   662 LRDPLLHDMDIYFLSI-IPEVKEKGPLSDIFMGCALLCHFMHGSYITRKGKGSSSFFLKACQYLL 725

  Fly   474 QITFIRHFLKTQTQHQLLAILQRHLKL----------SYLCAIRLETPSSVHTQM--QSFYAQQY 526
            :  .:.|.:::.::.  |..|||...|          |.:.::|..|.|.|.:..  |:.....|
plant   726 E--GLDHAVESVSKS--LNDLQRRGSLGFGSDFNEKGSIIVSLRSFTQSPVFSNRRDQNLLGASY 786

  Fly   527 ----------MRLF------QSEETQEIFCSNLP-----------------QLYISGFIKPEQLM 558
                      :|.|      .:|.........:|                 .|.::...|...::
plant   787 DFVIHSLENLLRSFAKVYEEYTEHAWNTHSDTVPSKSLAPDSPEVGRIVDMDLDLAEDTKERDII 851

  Fly   559 ----KALPTINNRSG--RAQVIRLLLCSQP--------------GKLSVFKVKDRI-----ELYC 598
                ||:|.:....|  :..::.|:.|..|              .|.|..||.:.|     :|.|
plant   852 AAGGKAVPGLPVSMGNWKLGMVSLISCFSPVLQFPTWDVLYNLLEKESDPKVLENILYHLCKLSC 916

  Fly   599 ----PKCRPLPKKLPGIYLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFECIAQHLDLLCFEPNV 659
                ||...|...|.|:...:.|.:..|.:. .|.|.::.:.|        .:...|....|.|.
plant   917 LTSIPKVDDLVIFLDGMLSTQVKMKRNCLNI-VTALHVLLHTL--------SSSRRDSSGVEKNC 972

  Fly   660 ILGLLRETEALQ----------KVS----------VKVI-------------GQLV--------- 682
            .|. |:|.|:.|          |||          ||:|             ||.:
plant   973 GLS-LKEAESFQVFVQLGAMVNKVSEFGLLGWFGRVKLINCICDLVLLNPQTGQTMIERLLLMLS 1036

  Fly   683 -SAMRVR-----------------SPEFLEQLANLVLAAIKAMLAKPLTEQNVL-----QQRSML 724
             |..|||                 ...|.:..::..:..:.:...|.:|.::||     .::.|.
plant  1037 DSDYRVRFVLARQIGILFQTWDGHEALFQDICSSFGIKLVTSSKEKLVTAKDVLAVGPQPRQKME 1101

  Fly   725 NVLTAIAHM--EDNEIWLFHWFKMTFFFLVHTRSLVAQEAVLAATEMCASQGLQTIHLWNWYKRD 787
            .|:..:.|:  ....|.|...|.|.   .|..:....:|.::||.:..::|    :|..:.:|
plant  1102 TVIITLMHLAYHSENIELQAVFMMC---AVSAKDPCQRELIIAALDNLSAQ----LHYPSRFK-- 1157

  Fly   788 ALDLTVRLALNVYLLDGVRFTRSLRAL--TKMLGFTCVQEFTCKY------HRLLTAMVLPHCIV 844
            .|:..:...|..::..||    ||..|  |..|   .:.....||      |.||.|::|.....
plant  1158 YLEELLGPILFHWIASGV----SLAGLIETSQL---FIPNAEPKYFIHFCSHWLLPALLLHEDHT 1215

  Fly   845 NPLCKGVLVLIAKQMQKHIGTLFSISFLRIYT-----HVFLTEEPE-----LANSCIELVVSCTQ 899
            |      |..:||...:.:..|...:|:.|::     |...|.|.:     |.|| |..|...::
plant  1216 N------LDWVAKMAGQPVVVLVKENFVPIFSICMGLHCSKTSECDKGAMVLQNS-ILYVGETSE 1273

  Fly   900 SSLQQLMNADVKQTVAELLIYFNRN-----PTFVMRSFQSLLQLSIGSLEELSSQTANAEFAN-- 957
            :...:|:..::...|:.:|...:.:     |||...:....:|..:....|.:....||...:
plant  1274 NERDKLIKQNMVSIVSFILSCASSSPEPPVPTFSRDTISLAVQTVVDGFLENTDYPKNAAITDRI 1338

  Fly   958 --FIAERFLGVITYFESCLSEPSFEK-------PLKEETLY---------SLGQIMRFVGSQHVT 1004
              |..:|....||.....:|.....:       .|:|.|:.         ||..|...||
plant  1339 NIFRPDRVFMFITEMHYRMSAACHHRHTRHHLAALEELTILLGHRALVPSSLNYIFNLVG----- 1398

  Fly  1005 QFRFKIIAMLSFVHTLQEPRLQRICLKIWHIFLHVVN-------VQELGPSLGRIVATLQPLLAD 1062
            ||             :..|.||..|..|....|.:..       |..||..|..:|:.|.....|
plant  1399 QF-------------IGYPSLQDQCCSIASCLLDLFKSNPAKEIVSVLGDQLQFLVSKLVTCCID 1450

  Fly  1063 NE---------SVKQVNDLYEFIILRNASMLGTFITDL-------YF-------LDRMENVSP-- 1102
            .|         |.:.||.|::.::..::| |...|.||       ||       :...|..||
plant  1451 AEADTKISGAKSSQLVNLLHKLVVSSDSS-LNEDIRDLEPLPDLKYFQVIRESHIRICEAYSPRN 1514

  Fly  1103 SIQKCIRRHTAHLDLKGLAEEENQSPPLVDQLRFLQKHITDECLQVRVYALQHLGDLFGRRRPKL 1167
            .:.||.||             .|..||     |||.:            :||.|.
plant  1515 HLLKCSRR-------------SNYLPP-----RFLSR------------SLQALH---------- 1539

  Fly  1168 NSTILSELPLEPML-----------EQIVN-----VLMAGCQHDDSQLQMASAKCLGELGAID-- 1214
            |..|.||:..|...           ::|||     |.::.....|| :::..:..|..:|..|
plant  1540 NKLIASEVSQEDTNGETAETFWQSDDEIVNAVWTLVRVSASDEADS-MRLLVSDFLSRIGIRDPH 1603

  Fly  1215 --ASYLPSN-----------YNFASP-QHLPLNILSDDFAVLALTSLCRGYQFQQNTKHVDSFSL 1265
              ..:||.|           :|..|. :.|..|.:||: .::.|.:..:.|....:.|.:|..|.
plant  1604 TVVFHLPGNLVSMHGLQGFGHNTGSKVRSLTENGISDE-TLITLLNFLKKYLLDDSVKIIDVTSQ 1667

  Fly  1266 AIQETLAICGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPSTCL----------QQPL 1320
            .::      ||...|:.: |...|..:..|.|:|         ||.....|          |:..
plant  1668 TLR------GILSTERGQ-QALSSFDSCERALIE---------VHGRGVNLDIVEKILLDSQKQF 1716

  Fly  1321 FGSHYSHNYYEEWAF------LWASRLI-------DYLPSSGRRHLLSSYKPCIKRDSNMLSTFY 1372
            ....:|....|.|:.      .|..:|:       :.:|..     |......:|.:.:.|  .:
plant  1717 KAEKFSLETPEVWSTDNKNFDRWICQLVYCMIALCEDVPIR-----LCQNIALLKAEISEL--LF 1774

  Fly  1373 PYIL------------LHALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQ-ELGAIKENAFK 1424
            |.::            ||.|:  |::.:.||          ..:|:...:.:| .|..:.|....
plant  1775 PSVVVSLAGRIGMDINLHDLI--TSQVKEHI----------FTDSNKLTKSKQVMLNTLNELRMC 1827

  Fly  1425 QFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPE 1489
            ....|...:|         ..::|.:||....|.|:               :.:...|.|  ...
plant  1828 YVLERSIFSG---------QTKREKNSRSCSTAAKI---------------RDVESGSNG--MAA 1866

  Fly  1490 TIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEE-------GE-DKS--QRLLEQ 1544
            :|.:|:.|:: :|: |..|:|:.::..||.|..|..|:|.:.||       |: |.|  .:|.:.
plant  1867 SITTNWEKVY-WLS-IDYLVVAGSAVVCGAYLTASMYVEYWCEEKFGNLSLGDPDFSYHDKLPDH 1929

  Fly  1545 FTFLVEVYGSLRDPDSVEGAV---------------------------QVRSYDMSVTQDILVNR 1582
            ...||.....:.:|||:.|.:                           |.||..|.|...:..|.
plant  1930 VEILVSAITRINEPDSLYGVIHSNKLSAQIITFEHEGNWTRALEYYDLQARSQKMVVPSSLSENL 1994

  Fly  1583 LVERQQDMITS--------------YEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQ 1633
            .||:.|...::              ::.|:.|..|....||   :|.|.|           ||..
plant  1995 EVEQFQPTTSARHSVFGEGEVQRQPFKGLIRSLQQTGCMHV---LDLYCR-----------GLTS 2045

  Fly  1634 RLSDRYSDQCFAECKSELLWRLGSYD-----------EMEELQSNWPAQCSQGCLKLRRPLTTRI 1687
            |......|..|.|.:.|..||.|.:|           .::..::|...:....||:..:    ..
plant  2046 REGCFQYDPEFIELQYEAAWRAGKWDFSLLYPQTHCQPLQHAKNNNYHESLHCCLRALQ----EG 2106

  Fly  1688 EFDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHEL----------------H---- 1732
            ::|.....::::..|.:.|.|...:.|....|..|:||.::|.|                |
plant  2107 DYDGFYGKLKDTKKELVLSISRASEESTEFIYSTVVKLQILHHLGLVWDLRWTTSSHQSVHGYLV 2171

  Fly  1733 ----CSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRL 1793
                |...::..::|          :.....||...:...|..:.:.|...:|||.:|..|....
plant  2172 KQMACVDPVIPTMDQ----------LSWLNKDWNSIITQTQLHMTLLEPFIAFRRVLLQILGCEK 2226

  Fly  1794 TDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLF---IERAKLLWQKGD 1855
            ....|||     :.|.:.....:.:..|..|...:....::...||...:   :|.||||..:|.
plant  2227 CTMQHLL-----QSASLLRKGTRFSHAAASLHEFKFLCARSNGQQPVPDWLGKLEEAKLLHAQGR 2286

  Fly  1856 QVMAM---NYL-------EEQLSIMRSGCQGNVKQLAAEQRHLFFR---GKYLQ-AVYSAE--SM 1904
            ..:::   ||:       ||...|.|.     :.:..||.|....|   .|||: ||..||  |.
plant  2287 HEVSISLANYILHNYQLKEEASDIYRV-----IGKWLAETRSSNSRTILEKYLRPAVSLAEEQSS 2346

  Fly  1905 HLC-----------------ADAVLKYFQEAIA-----------VHRQSE--------------- 1926
            .:|                 |||:.|.::|.::           .|:..|
plant  2347 KICKRLVDRQSQTWFHLAHYADALFKSYEERLSSSEWQAALRLRKHKTKELEVLIKRFKSSKKAE 2411

  Fly  1927 -SCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDT 1990
             |.:....|.|:|.|...:....:...::|:.|...:..|.:.|..|.::..:.:.|.:|:|...
plant  2412 QSDYSLKIQDLQKQLTMDKEEAEKLQVDRDNFLKLALEGYKRCLEIGDKYDVRVVFRQVSMWFSL 2476

  Fly  1991 TESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHP-----VNDVFTVLRNVIIKLVE 2050
            ...       |.:.|.:.:....:.:..|..:..|:.|||...     .|...:.|.::|.|:..
plant  2477 ASQ-------KNVIDNMLSTIKEVQSYKFIPLVYQIASRLGSSKDESGSNSFQSALVSLIRKMAI 2534

  Fly  2051 AYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTF----------QKLLQDFN----SLTE 2101
            .:|..::..||   ..|...|||       |::...::|          :.||||.:    .:..
plant  2535 DHPYHTILQLL---ALANGDRIK-------DNQRSRNSFVVDMDKKLAAEHLLQDVSHYHGPMIR 2589

  Fly  2102 RLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQPEFSQILLPFE----KYMQ------PTLPLNSDS 2156
            ::..|      :|...||::|:||     ::....::.||.|    |.::      .|:|::...
plant  2590 QMKQL------VDIYIKLAELETR-----REDTNRKVALPREIRSVKQLELVPVVTATIPVDRSC 2643

  Fly  2157 NSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKP-KDDL 2220
            ..:|||           ||    :..|..:||.::.....||.:....|||:.|..|.|. .|||
plant  2644 QYNEGS-----------FP----FFRGLSDSVTVMNGINAPKVVECFGSDGQKYKQLAKSGNDDL 2693

  Fly  2221 RRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPN--------LASYRS- 2276
            |:||.:.:|.|||..:||.:....:|||.:|||.|:||....|::||:..        :.|.||
plant  2694 RQDAVMEQFFGLVNTFLHNNRDTWKRRLAVRTYKVIPFTPSAGVLEWVDGTIPLGDYLIGSSRSE 2758

  Fly  2277 -------ICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFAT 2334
                   |....|.:.|..||             |.:.||:.|. .:.....||...:..::|..
plant  2759 GAHGRYGIGNWKYPKCREHMS-------------SAKDKRKAFV-DVCTNFRPVMHYFFLEKFLQ 2809

  Fly  2335 PHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVV 2399
            |..|:..|..|.|:||..||||||:||||||..|||..:...:.||:|....|.||.:|..||.|
plant  2810 PADWFVKRLAYTRSVAASSMVGYIVGLGDRHAMNILIDQATAEVVHIDLGVAFEQGLMLKTPERV 2874

  Fly  2400 PFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDV----GAQTRKGAATA 2460
            |||||.::|..||..||||.||:|||.||.:::...:.|::|:..|::|.    .....|.....
plant  2875 PFRLTRDIIDGMGITGVEGVFRRCCEETLSVMRTNKEALLTIVEVFIHDPLYKWALSPLKALQRQ 2939

  Fly  2461 KITKD----------------------VQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKV 2503
            |.|:|                      :.|:..:|.|:...:..     |..||...||.:|...
plant  2940 KETEDYDGMNLEGLQEEFEGNKDATRALMRVKQKLDGYEGGEMR-----SIHGQAQQLIQDAIDT 2999

  Fly  2504 DNLASMYIGWGAFL 2517
            |.|:.|:.||||::
plant  3000 DRLSHMFPGWGAWM 3013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	27/131 (21%)
		FAT	1653..1985	CDD:280429	81/429 (19%)
		PIKKc_ATR	2181..2448	CDD:270625	104/283 (37%)
		FATC	2486..2517	CDD:280430	13/30 (43%)
ATM	NP_001326746.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920